INT122930

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Context Info
Confidence 0.49
First Reported 2004
Last Reported 2006
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 0.91
Pain Relevance 0.54

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

small molecule metabolic process (CACNA1A) cell death (CACNA1A) plasma membrane (CACNA1A)
nucleus (CACNA1A) transmembrane transport (CACNA1A) cytoplasm (CACNA1A)
Anatomy Link Frequency
HeLa 2
CACNA1A (Homo sapiens)
Pain Link Frequency Relevance Heat
Migraine 6 100.00 Very High Very High Very High
Calcium channel 11 80.44 Quite High
Neurotransmitter 5 5.00 Very Low Very Low Very Low
gABA 2 5.00 Very Low Very Low Very Low
Central nervous system 1 5.00 Very Low Very Low Very Low
Glutamate 1 5.00 Very Low Very Low Very Low
Neuropeptide 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Migraine With Aura 4 100.00 Very High Very High Very High
Repression 3 100.00 Very High Very High Very High
Headache 2 94.12 High High
Intellectual Impairment 1 92.32 High High
Hemiplegia 3 91.40 High High
Disease 4 5.00 Very Low Very Low Very Low
Anaplastic Astrocytoma 1 5.00 Very Low Very Low Very Low
Epilepsy 1 5.00 Very Low Very Low Very Low
Cerebellar Diseases 1 5.00 Very Low Very Low Very Low
Nervous System Malformation 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
A second gene for FHM was discovered recently: the ATP1A2 gene on chromosome 1q23, coding for the alpha 2 subunit of Na+,K+-ATPase.
Positive_regulation (discovered) of Gene_expression (discovered) of FHM associated with migraine
1) Confidence 0.49 Published 2004 Journal Neuropediatrics Section Abstract Doc Link 15534763 Disease Relevance 0.81 Pain Relevance 0.46
Virally mediated overexpression of a dominant-negative REST construct resulted in 75-fold de-repression of CACNA1A mRNA levels in HeLa cells (Figure 4A), indicating that REST is capable of strongly repressing this gene.
Positive_regulation (overexpression) of Gene_expression (overexpression) of CACNA1A in HeLa associated with repression
2) Confidence 0.42 Published 2006 Journal Nucleic Acids Research Section Body Doc Link PMC1557810 Disease Relevance 0.10 Pain Relevance 0.08

General Comments

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