INT122951

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Context Info
Confidence 0.39
First Reported 2003
Last Reported 2009
Negated 1
Speculated 2
Reported most in Abstract
Documents 4
Total Number 6
Disease Relevance 3.08
Pain Relevance 1.65

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (HLA-B)
Anatomy Link Frequency
groove 2
T cells 2
HLA-B (Homo sapiens)
Pain Link Frequency Relevance Heat
spinal inflammation 72 100.00 Very High Very High Very High
rheumatoid arthritis 6 75.68 Quite High
spondylitis 4 70.96 Quite High
Arthritis 7 35.48 Quite Low
Inflammation 7 35.08 Quite Low
cytokine 3 5.00 Very Low Very Low Very Low
Multiple sclerosis 2 5.00 Very Low Very Low Very Low
imagery 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Seronegative Spondarthritis 8 100.00 Very High Very High Very High
Autoimmune Disease 4 99.24 Very High Very High Very High
Low Back Pain 71 98.80 Very High Very High Very High
Disease 37 97.44 Very High Very High Very High
Targeted Disruption 7 87.92 High High
Rheumatoid Arthritis 7 75.68 Quite High
Stress 1 74.00 Quite High
Cytomegalovirus Infection 14 64.32 Quite High
Skin Cancer 1 63.32 Quite High
Epstein-barr Virus 12 62.48 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
OBJECTIVE: There is an established association between the development of ankylosing spondylitis (AS) and the HLA-B27 allele, but whether or not homozygosity for HLA B27 has any additional effects on the clinical manifestations of AS is unclear.
Spec (whether) Regulation (effects) of HLA-B27 allele Neg (not) Spec (whether) Binding (association) of associated with seronegative spondarthritis and spinal inflammation
1) Confidence 0.39 Published 2009 Journal Clin. Exp. Rheumatol. Section Abstract Doc Link 19772787 Disease Relevance 0.47 Pain Relevance 0.46
The mutual electrostatic interactions of peptide and HLA molecule, including peptide- and subtype-dependent protonation of key residues, modulate complex stability and antigenic features of the respective HLA-B27 subtype.
Regulation (modulate) of HLA-B27 Binding (stability) of
2) Confidence 0.29 Published 2008 Journal J. Biol. Chem. Section Abstract Doc Link 18505734 Disease Relevance 0 Pain Relevance 0
These combined results demonstrate how the deeply embedded polymorphic heavy-chain residue 116 influences the flexibility of the peptide binding groove in a subtype-dependent manner, a feature that could also influence the recognition of the HLA-B27 complexes by effector cells.
Regulation (influence) of HLA-B27 Binding (recognition) of in groove
3) Confidence 0.27 Published 2008 Journal J. Mol. Biol. Section Abstract Doc Link 18178223 Disease Relevance 0.14 Pain Relevance 0.06
However, factors influencing the formation of HLA-B27 heavy-chain dimers remain poorly characterised.
Regulation (influencing) of HLA-B27 Binding (formation) of
4) Confidence 0.26 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2575614 Disease Relevance 0.60 Pain Relevance 0.24
It could also be involved in the differential association of the human major histocompatibility subtypes HLA-B(*)2705 and HLA-B(*)2709 with ankylosing spondylitis.
Regulation (involved) of HLA-B Binding (association) of associated with spinal inflammation
5) Confidence 0.26 Published 2005 Journal J. Biol. Chem. Section Abstract Doc Link 15537660 Disease Relevance 0.28 Pain Relevance 0.10
NK receptor mediated recognition of HLA-B27 may be responsible for peptide independent activation of these CD4+ T cells in AS disease.
Spec (may) Regulation (responsible) of HLA-B27 Binding (recognition) of in T cells associated with spinal inflammation and disease
6) Confidence 0.09 Published 2003 Journal Arthritis Res Ther Section Body Doc Link PMC193730 Disease Relevance 1.60 Pain Relevance 0.78

General Comments

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