INT122952

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Context Info
Confidence 0.50
First Reported 2005
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 13
Total Number 13
Disease Relevance 8.10
Pain Relevance 8.89

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (COMT) mitochondrion (COMT) small molecule metabolic process (COMT)
plasma membrane (COMT) cytoplasm (COMT)
Anatomy Link Frequency
cingulate cortex 1
striatum 1
COMT (Homo sapiens)
COMT - V158M (1)
Pain Link Frequency Relevance Heat
Catechol-O-methyltransferase 544 100.00 Very High Very High Very High
Anterior cingulate cortex 34 100.00 Very High Very High Very High
Pain 219 99.90 Very High Very High Very High
monoamine 2 99.68 Very High Very High Very High
Opioid 18 98.28 Very High Very High Very High
Enkephalin 6 97.40 Very High Very High Very High
Snapping jaw 1 96.12 Very High Very High Very High
Lasting pain 11 92.04 High High
depression 30 89.52 High High
Thalamus 5 87.68 High High
Disease Link Frequency Relevance Heat
Pain 211 99.90 Very High Very High Very High
Melanoma 115 98.86 Very High Very High Very High
Restless Legs Syndrome 6 98.84 Very High Very High Very High
Hantavirus Infection 158 98.00 Very High Very High Very High
Temporomandibular Joint Disorders 13 96.68 Very High Very High Very High
Cognitive Disorder 20 96.00 Very High Very High Very High
Reprotox - General 1 2 95.60 Very High Very High Very High
Depression 36 89.52 High High
Sleep Disorders 6 88.08 High High
Cancer 20 86.32 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The highly methylated environment in human melanoma cell lines (e.g., SkMel-28) has been reported, and both COMT (Cathechol O-methyl transferase) and DNA methyltransferase-1 were found to be increased approximately five and eight times, respectively [33].
Positive_regulation (increased) of COMT associated with melanoma
1) Confidence 0.50 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2973952 Disease Relevance 0.76 Pain Relevance 0.03
Another frequently studied gene is catechol-o-methyltransferase (COMT) that is related to the monoamine catabolism.
Positive_regulation (related) of COMT associated with monoamine
2) Confidence 0.49 Published 2010 Journal Qual Life Res Section Body Doc Link PMC2977055 Disease Relevance 0.79 Pain Relevance 0.27
This could explain the lack of a relationship between pain ratings on one hand and COMT genotype and fMRI BOLD activation on the other hand.
Positive_regulation (activation) of COMT associated with catechol-o-methyltransferase and pain
3) Confidence 0.47 Published 2010 Journal Mol Pain Section Body Doc Link PMC2887789 Disease Relevance 0.96 Pain Relevance 1.09
The val158met polymorphism of human catechol-O-methyltransferase (COMT) affects anterior cingulate cortex activation in response to painful laser stimulation.
Positive_regulation (activation) of COMT in cingulate cortex associated with pain, catechol-o-methyltransferase and anterior cingulate cortex
4) Confidence 0.47 Published 2010 Journal Mol Pain Section Title Doc Link 20509977 Disease Relevance 0.61 Pain Relevance 1.39
The same reaction in the presence of 15 mM EDTA was carried out in parallel for each lysate to bind Mg+2 ions required for COMT activity.
Positive_regulation (required) of COMT associated with catechol-o-methyltransferase
5) Confidence 0.47 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2664927 Disease Relevance 0 Pain Relevance 0.21
The LPS haplotype produces much higher levels of COMT enzymatic activity when compared with the APS or HPS haplotypes.
Positive_regulation (levels) of COMT associated with hantavirus infection
6) Confidence 0.46 Published 2005 Journal Hum. Mol. Genet. Section Abstract Doc Link 15537663 Disease Relevance 1.34 Pain Relevance 1.17
We also observed that non-affected relatives of FM patients had a reduced percentage of the COMT met allele.
Positive_regulation (percentage) of COMT
7) Confidence 0.44 Published 2009 Journal Clin. Exp. Rheumatol. Section Body Doc Link 20074440 Disease Relevance 0.22 Pain Relevance 0
In the striatum, mRNA levels were significantly higher in COMT Met(108/158) homozygous cases indicating that MOP binding sites and enkephalin are regulated in parallel.
Positive_regulation (higher) of COMT Met in striatum associated with catechol-o-methyltransferase, enkephalin and opioid
8) Confidence 0.44 Published 2005 Journal Neuroimage Section Abstract Doc Link 16040257 Disease Relevance 0.06 Pain Relevance 1.30
This result would suggest the presence of a number of putative negatively regulating elements along the P2-COMT promoter other than ER- and ?
Positive_regulation (elements) of P2-COMT associated with catechol-o-methyltransferase
9) Confidence 0.43 Published 2009 Journal Mol Pain Section Body Doc Link PMC2662804 Disease Relevance 0.38 Pain Relevance 0.49
Interestingly, consequent deletions of 5'fragments of the P2-COMT promoter led to a significant increase in overall basal promoter activity.
Positive_regulation (increase) of P2-COMT associated with catechol-o-methyltransferase
10) Confidence 0.43 Published 2009 Journal Mol Pain Section Body Doc Link PMC2662804 Disease Relevance 0.36 Pain Relevance 0.40
By combining these SNPs, Diatchenko and colleagues [10] were able to identify frequent COMT gene haplotypes strongly associated with sensitivity to experimental pain and induction of a more defective COMT enzyme.
Positive_regulation (induction) of COMT enzyme associated with pain and catechol-o-methyltransferase
11) Confidence 0.43 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC2212567 Disease Relevance 0.85 Pain Relevance 1.11
The minor 675A allele produces a valine to methionine substitution, resulting in a less thermostable COMT enzyme that exhibits a 3-fold reduction in activity [30].
Positive_regulation (resulting) of COMT enzyme associated with catechol-o-methyltransferase
12) Confidence 0.41 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2664927 Disease Relevance 0.79 Pain Relevance 0.90
The data revealed no significant differences in the distribution of the COMT val(158)met polymorphism in RLS patients compared with the control group, also when the heterozygous and the homozygous group containing the (158)met allele were combined.
Positive_regulation (distribution) of COMT (V158M) associated with catechol-o-methyltransferase and restless legs syndrome
13) Confidence 0.41 Published 2010 Journal Neurosci. Lett. Section Abstract Doc Link 20184941 Disease Relevance 0.96 Pain Relevance 0.53

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