INT122953

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Context Info
Confidence 0.77
First Reported 2005
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 65
Total Number 65
Disease Relevance 25.84
Pain Relevance 40.49

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (COMT) mitochondrion (COMT) small molecule metabolic process (COMT)
plasma membrane (COMT) cytoplasm (COMT)
Anatomy Link Frequency
brain 6
astrocytes 4
neurons 2
liver 1
central nervous system 1
COMT (Homo sapiens)
COMT - V158M (1)
Pain Link Frequency Relevance Heat
Catechol-O-methyltransferase 4833 100.00 Very High Very High Very High
Central nervous system 177 99.68 Very High Very High Very High
Dopamine 404 99.56 Very High Very High Very High
Pain 1177 99.48 Very High Very High Very High
narcan 9 99.36 Very High Very High Very High
Fibrositis 143 99.16 Very High Very High Very High
Morphine 60 99.16 Very High Very High Very High
Opioid 74 98.80 Very High Very High Very High
IPN 189 98.56 Very High Very High Very High
Inflammation 258 98.48 Very High Very High Very High
Disease Link Frequency Relevance Heat
Hantavirus Infection 704 99.98 Very High Very High Very High
Anaplastic Astrocytoma 248 99.84 Very High Very High Very High
Anxiety Disorder 462 99.80 Very High Very High Very High
Pain 1172 99.48 Very High Very High Very High
Schizophrenia 89 99.36 Very High Very High Very High
Fibromyalgia 125 99.16 Very High Very High Very High
Inflammatory Pain 189 98.56 Very High Very High Very High
INFLAMMATION 320 98.48 Very High Very High Very High
Nociception 97 97.76 Very High Very High Very High
Acute Liver Failure 1 97.56 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
regulates COMT expression, we cloned the human distal COMT promoter (P2-COMT) which controls transcription of MB-COMT mRNA (Figure 2A).
Gene_expression (expression) of COMT associated with catechol-o-methyltransferase
1) Confidence 0.77 Published 2009 Journal Mol Pain Section Body Doc Link PMC2662804 Disease Relevance 0.05 Pain Relevance 0.60
-mediated inhibition of COMT expression in astroglioma cells is P2-COMT promoter specific (P < 0.05; Figure 2C).
Gene_expression (expression) of COMT associated with anaplastic astrocytoma and catechol-o-methyltransferase
2) Confidence 0.77 Published 2009 Journal Mol Pain Section Body Doc Link PMC2662804 Disease Relevance 0.24 Pain Relevance 0.45
Using TFSearch database [51], we analyzed the cloned sequence and identified a number of potential transcription factor binding elements that can affect both constitutive and tissue-specific expression of COMT gene, such as TATA and CAAT boxes, CRE, C/EBP, and NF-?
Gene_expression (expression) of COMT associated with catechol-o-methyltransferase
3) Confidence 0.77 Published 2009 Journal Mol Pain Section Body Doc Link PMC2662804 Disease Relevance 0.06 Pain Relevance 0.56
B-dependent inhibition of COMT gene expression.
Gene_expression (expression) of COMT associated with catechol-o-methyltransferase
4) Confidence 0.77 Published 2009 Journal Mol Pain Section Body Doc Link PMC2662804 Disease Relevance 0.25 Pain Relevance 0.36
A number of putative regulatory elements have been described in P1- and P2-COMT promoters, including estrogen response (ER) elements [50] that likely mediate estradiol-dependent downregulation of COMT expression in cell culture [55].
Gene_expression (expression) of COMT associated with catechol-o-methyltransferase
5) Confidence 0.77 Published 2009 Journal Mol Pain Section Body Doc Link PMC2662804 Disease Relevance 0.36 Pain Relevance 0.47
Our results demonstrating that COMT expression is downregulated in astrocytes under inflammatory conditions are in line with those of other studies showing a positive correlation between astrocyte activation and exaggerated pain responses [24,25,61].
Gene_expression (expression) of COMT in astrocyte associated with pain, catechol-o-methyltransferase and inflammation
6) Confidence 0.77 Published 2009 Journal Mol Pain Section Body Doc Link PMC2662804 Disease Relevance 0.46 Pain Relevance 0.59
B activation alone would repress COMT gene expression.
Gene_expression (expression) of COMT associated with catechol-o-methyltransferase
7) Confidence 0.77 Published 2009 Journal Mol Pain Section Body Doc Link PMC2662804 Disease Relevance 0.14 Pain Relevance 0.37
Although, to date, no studies have systematically searched for regulators of COMT expression, this finding clearly warrants further research.
Gene_expression (expression) of COMT associated with catechol-o-methyltransferase
8) Confidence 0.77 Published 2009 Journal Mol Pain Section Body Doc Link PMC2662804 Disease Relevance 0.47 Pain Relevance 0.56
B-mediated regulation of COMT expression as deletion of the P2-COMT region containing this site abrogated TNF?
Gene_expression (expression) of COMT associated with catechol-o-methyltransferase
9) Confidence 0.77 Published 2009 Journal Mol Pain Section Body Doc Link PMC2662804 Disease Relevance 0.48 Pain Relevance 0.40
Endogenous morphine signaling via nitric oxide regulates the expression of CYP2D6 and COMT: autocrine/paracrine feedback inhibition.
Gene_expression (expression) of COMT associated with narcan and morphine
10) Confidence 0.74 Published 2008 Journal Addict Biol Section Title Doc Link 17573783 Disease Relevance 0 Pain Relevance 0.67
The analysis showed similar changes in the expression of CYP2D6 and COMT mRNA.
Gene_expression (expression) of COMT mRNA
11) Confidence 0.74 Published 2008 Journal Addict Biol Section Abstract Doc Link 17573783 Disease Relevance 0 Pain Relevance 0.69
The verification of the microarray data was accomplished via real-time Taqman reverse transcriptase polymerase chain reaction (RT-PCR) focused on CYP2D6 and COMT expression in different blood samples treated with morphine.
Gene_expression (expression) of COMT in blood associated with morphine
12) Confidence 0.74 Published 2008 Journal Addict Biol Section Abstract Doc Link 17573783 Disease Relevance 0 Pain Relevance 0.62
Furthermore, exposure of white blood cells to 10(-6) M S-nitroso-N-acetyl-DL-penicillamine (SNAP), a nitric oxide (NO) donor, reduced the expression of CYP2D6 and COMT.
Gene_expression (expression) of COMT in white blood cells
13) Confidence 0.74 Published 2008 Journal Addict Biol Section Abstract Doc Link 17573783 Disease Relevance 0 Pain Relevance 0.97
In cells expressing S- or MB-COMT, the APS haplotype displays a modest 3-fold reduction in enzymatic activity likely due to the previously reported decrease in protein thermostability coded by the met158 allele.
Gene_expression (expressing) of MB-COMT associated with catechol-o-methyltransferase
14) Confidence 0.68 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2664927 Disease Relevance 1.17 Pain Relevance 0.71
S-COMT is predominately expressed in peripheral tissues, while MB-COMT is predominatly expressed in brain.
Gene_expression (expressed) of MB-COMT in brain associated with catechol-o-methyltransferase
15) Confidence 0.68 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2664927 Disease Relevance 0.44 Pain Relevance 0.68
S-COMT is predominately expressed in peripheral tissues, while MB-COMT is predominatly expressed in brain.
Gene_expression (expressed) of S-COMT in brain associated with catechol-o-methyltransferase
16) Confidence 0.68 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2664927 Disease Relevance 0.37 Pain Relevance 0.66
Genotyping of the COMT locus
Gene_expression (locus) of COMT associated with catechol-o-methyltransferase
17) Confidence 0.68 Published 2006 Journal BMC Musculoskelet Disord Section Body Doc Link PMC1524765 Disease Relevance 0.76 Pain Relevance 0.75
In a subsequent paper Zubieta et al. [10] showed that the COMT val158met polymorphism affects the ?
Gene_expression (polymorphism) of COMT val158met (V158M) associated with catechol-o-methyltransferase
18) Confidence 0.67 Published 2010 Journal Mol Pain Section Body Doc Link PMC2887789 Disease Relevance 0.68 Pain Relevance 1.27
Therefore our data are consistent with previous studies that found an association of the COMT met158 allele with higher pain ratings [10,13] and with altered ?
Gene_expression (met158 allele) of COMT associated with pain and catechol-o-methyltransferase
19) Confidence 0.67 Published 2010 Journal Mol Pain Section Body Doc Link PMC2887789 Disease Relevance 0.87 Pain Relevance 1.70
Main effects were not observed for COMT genotype in any of the regression models.

3.3.

Gene_expression (genotype) of COMT
20) Confidence 0.67 Published 2010 Journal Interdisciplinary Perspectives on Infectious Diseases Section Body Doc Link PMC2804107 Disease Relevance 0.14 Pain Relevance 0

General Comments

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