INT122987

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Context Info
Confidence 0.42
First Reported 2004
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 5
Total Number 5
Disease Relevance 4.58
Pain Relevance 0.21

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (CLU) endoplasmic reticulum (CLU) lipid metabolic process (CLU)
cytoplasm (CLU) cytosol (CLU) extracellular space (CLU)
CLU (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 2 73.60 Quite High
Analgesic 3 71.52 Quite High
local anesthetic 2 45.20 Quite Low
Pain 8 5.00 Very Low Very Low Very Low
antagonist 6 5.00 Very Low Very Low Very Low
metalloproteinase 6 5.00 Very Low Very Low Very Low
positron emission tomography 5 5.00 Very Low Very Low Very Low
Chronic pancreatitis 4 5.00 Very Low Very Low Very Low
imagery 3 5.00 Very Low Very Low Very Low
cva 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Disorder Of Lipid Metabolism 15 100.00 Very High Very High Very High
Breast Cancer 20 99.84 Very High Very High Very High
Ovarian Cancer 22 97.16 Very High Very High Very High
Death 12 96.00 Very High Very High Very High
Apoptosis 30 87.76 High High
Cancer 244 84.36 Quite High
Prostate Cancer 111 81.48 Quite High
Bladder Cancer 14 72.32 Quite High
Malignant Neoplastic Disease 7 69.84 Quite High
Fatigue 4 67.28 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Of them, alpha-1-acid glycoprotein and clusterin were expressly down-regulated in breast cancer, whereas transthyretin was decreased specifically in ovarian cancer.
Negative_regulation (regulated) of clusterin associated with ovarian cancer and breast cancer
1) Confidence 0.42 Published 2007 Journal Mol Cancer Section Body Doc Link PMC1852117 Disease Relevance 1.15 Pain Relevance 0
Of them, alpha-1-acid glycoprotein and clusterin were expressly down-regulated in breast cancer, whereas transthyretin was decreased specifically in ovarian cancer.
Negative_regulation (down) of clusterin associated with ovarian cancer and breast cancer
2) Confidence 0.42 Published 2007 Journal Mol Cancer Section Body Doc Link PMC1852117 Disease Relevance 1.14 Pain Relevance 0
Furthermore, the downregulation of endogenous clusterin/apolipoprotein J levels by ropivacaine suggested that this might be one mechanism by which ropivacaine induced cell death in HaCaT cells.
Negative_regulation (downregulation) of clusterin associated with death and disorder of lipid metabolism
3) Confidence 0.41 Published 2004 Journal Cell Res. Section Abstract Doc Link 15538973 Disease Relevance 0.87 Pain Relevance 0.11
Furthermore, the downregulation of endogenous clusterin/apolipoprotein J levels by ropivacaine suggested that this might be one mechanism by which ropivacaine induced cell death in HaCaT cells.
Negative_regulation (downregulation) of apolipoprotein J associated with death and disorder of lipid metabolism
4) Confidence 0.18 Published 2004 Journal Cell Res. Section Abstract Doc Link 15538973 Disease Relevance 0.87 Pain Relevance 0.11
Significant decrease in mean serum clusterin levels measured on day 1 of cycle 2 was noted with custirsen (?
Negative_regulation (decrease) of clusterin
5) Confidence 0.18 Published 2010 Journal OncoTargets and therapy Section Body Doc Link PMC2895780 Disease Relevance 0.55 Pain Relevance 0

General Comments

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