INT122988

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Context Info
Confidence 0.75
First Reported 2004
Last Reported 2011
Negated 0
Speculated 0
Reported most in Body
Documents 28
Total Number 28
Disease Relevance 24.07
Pain Relevance 1.21

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (CLU) endoplasmic reticulum (CLU) lipid metabolic process (CLU)
cytoplasm (CLU) cytosol (CLU) extracellular space (CLU)
Anatomy Link Frequency
colon 4
bladder 4
lung 4
kidney 4
chondrocytes 2
CLU (Homo sapiens)
Pain Link Frequency Relevance Heat
rheumatoid arthritis 32 99.64 Very High Very High Very High
local anesthetic 5 96.64 Very High Very High Very High
Infliximab 44 94.48 High High
Inflammatory mediators 2 92.32 High High
metalloproteinase 7 91.24 High High
Inflammation 16 78.96 Quite High
Osteoarthritis 180 77.00 Quite High
Pain 159 61.04 Quite High
positron emission tomography 95 51.52 Quite High
Analgesic 24 48.40 Quite Low
Disease Link Frequency Relevance Heat
Disease 506 100.00 Very High Very High Very High
Disorder Of Lipid Metabolism 34 100.00 Very High Very High Very High
Stress 25 100.00 Very High Very High Very High
Injury 8 100.00 Very High Very High Very High
Prostate Cancer 2109 99.84 Very High Very High Very High
Apoptosis 118 99.72 Very High Very High Very High
Rheumatoid Arthritis 32 99.64 Very High Very High Very High
Arthritis 6 99.40 Very High Very High Very High
Recurrence 40 97.32 Very High Very High Very High
Colon Cancer 38 95.92 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Ectopic expression of clusterin/apolipoprotein J or Bcl-2 decreases the sensitivity of HaCaT cells to toxic effects of ropivacaine.
Gene_expression (expression) of clusterin associated with disorder of lipid metabolism
1) Confidence 0.75 Published 2004 Journal Cell Res. Section Title Doc Link 15538973 Disease Relevance 0.60 Pain Relevance 0.10
To investigate the role of clusterin/apoliporotein J in ropivacaine-induced apoptosis, HaCaT cells overexpressing clusterin/apoliporotein J were generated and compared to cells expressing the well established anti-apoptotic Bcl-2 protein.
Gene_expression (overexpressing) of clusterin associated with apoptosis
2) Confidence 0.75 Published 2004 Journal Cell Res. Section Abstract Doc Link 15538973 Disease Relevance 0.80 Pain Relevance 0.06
In addition, ropivacaine downregulated the expression of clusterin/ apoliporotein J, a protein with anti-apoptotic properties, in a dose-dependent manner, which well correlated with the induction of apoptosis of HaCaT cells.
Gene_expression (expression) of clusterin associated with apoptosis
3) Confidence 0.75 Published 2004 Journal Cell Res. Section Abstract Doc Link 15538973 Disease Relevance 0.67 Pain Relevance 0.07
Ectopic expression of clusterin/apolipoprotein J or Bcl-2 decreases the sensitivity of HaCaT cells to toxic effects of ropivacaine.
Gene_expression (expression) of apolipoprotein J associated with disorder of lipid metabolism
4) Confidence 0.75 Published 2004 Journal Cell Res. Section Title Doc Link 15538973 Disease Relevance 0.60 Pain Relevance 0.10
The high-affinity genotype of FCGR3B (NA1/NA1) was the most prevalent genotype in the patients with RA (44%), while the NA1/NA2 and NA2/NA2 genotypes were found in 33% and 23% of patients, respectively.
Gene_expression (found) of NA1/NA2 associated with rheumatoid arthritis
5) Confidence 0.65 Published 2011 Journal Annals of the Rheumatic Diseases Section Body Doc Link PMC3015102 Disease Relevance 0.25 Pain Relevance 0.21
Ectopic overexpression of the secreted form of clusterin/apoliporotein J or Bcl-2 decreased the sensitivity of HaCaT cells to toxic effects of ropivacaine as demonstrated by DNA fragmentation, the proteolytic cleavage of PARP and by a reduction in procaspase-3 expression.
Gene_expression (overexpression) of clusterin in cleavage
6) Confidence 0.65 Published 2004 Journal Cell Res. Section Abstract Doc Link 15538973 Disease Relevance 0.90 Pain Relevance 0.08
Serum clusterin levels in CRPC
Gene_expression (levels) of clusterin associated with prostate cancer
7) Confidence 0.37 Published 2010 Journal OncoTargets and therapy Section Body Doc Link PMC2895780 Disease Relevance 0.90 Pain Relevance 0
Several studies have demonstrated clusterin overexpression in prostate cancer especially after hormone therapy.13,39 Clustein expression has also reported to be a possible predictor for biochemical recurrence following prostatectomy.14 An antisense oligonucleotide directed against clusterin (custirsen, OGX-011) has been developed, and successful downregulation of clusterin expression was shown in primary prostate cancers in a phase I study.40
Gene_expression (expression) of clusterin associated with prostate cancer and recurrence
8) Confidence 0.37 Published 2010 Journal OncoTargets and therapy Section Body Doc Link PMC2895780 Disease Relevance 0.65 Pain Relevance 0
Clusterin, also known as apolipoprotein J, is a stress-induced cyto-protective chaperone protein expressed in virtually all human tissues.10 Clusterin over-expression is demonstrated in various human malignancies including prostate, breast, lung, bladder, kidney, and colon cancers.11 In prostate cancer, clusterin levels are low in hormone-naïve tissue, but increase significantly after hormone therapy.12 Clusterin levels have also been correlated with preoperative PSA value and also the pathological grade on both biopsy and radical prostatectomy specimens.13 Further, clusterin expression has also been reported to be a possible predictor for biochemical recurrence following radical prostatectomy.14 In a recent phase II clinical trial,15 serum levels of clusterin was used a biomarker of response and was reported to be significantly reduced following treatment with OGX-011, an antisense oligonucleotide against clusterin.
Gene_expression (expression) of clusterin in colon associated with stress, colon cancer, prostate cancer, recurrence and disorder of lipid metabolism
9) Confidence 0.37 Published 2010 Journal OncoTargets and therapy Section Body Doc Link PMC2895780 Disease Relevance 0.86 Pain Relevance 0.03
Clusterin, also known as apolipoprotein J, is a stress-induced cyto-protective chaperone protein expressed in virtually all human tissues.10 Clusterin over-expression is demonstrated in various human malignancies including prostate, breast, lung, bladder, kidney, and colon cancers.11 In prostate cancer, clusterin levels are low in hormone-naïve tissue, but increase significantly after hormone therapy.12 Clusterin levels have also been correlated with preoperative PSA value and also the pathological grade on both biopsy and radical prostatectomy specimens.13 Further, clusterin expression has also been reported to be a possible predictor for biochemical recurrence following radical prostatectomy.14 In a recent phase II clinical trial,15 serum levels of clusterin was used a biomarker of response and was reported to be significantly reduced following treatment with OGX-011, an antisense oligonucleotide against clusterin.
Gene_expression (over) of Clusterin in colon associated with stress, colon cancer, prostate cancer, recurrence and disorder of lipid metabolism
10) Confidence 0.32 Published 2010 Journal OncoTargets and therapy Section Body Doc Link PMC2895780 Disease Relevance 0.97 Pain Relevance 0
Several studies have demonstrated clusterin overexpression in prostate cancer especially after hormone therapy.13,39 Clustein expression has also reported to be a possible predictor for biochemical recurrence following prostatectomy.14 An antisense oligonucleotide directed against clusterin (custirsen, OGX-011) has been developed, and successful downregulation of clusterin expression was shown in primary prostate cancers in a phase I study.40
Gene_expression (overexpression) of clusterin associated with prostate cancer and recurrence
11) Confidence 0.32 Published 2010 Journal OncoTargets and therapy Section Body Doc Link PMC2895780 Disease Relevance 0.67 Pain Relevance 0
Clusterin, also known as apolipoprotein J, is a stress-induced cyto-protective chaperone protein expressed in virtually all human tissues.10 Clusterin over-expression is demonstrated in various human malignancies including prostate, breast, lung, bladder, kidney, and colon cancers.11 In prostate cancer, clusterin levels are low in hormone-naïve tissue, but increase significantly after hormone therapy.12 Clusterin levels have also been correlated with preoperative PSA value and also the pathological grade on both biopsy and radical prostatectomy specimens.13 Further, clusterin expression has also been reported to be a possible predictor for biochemical recurrence following radical prostatectomy.14 In a recent phase II clinical trial,15 serum levels of clusterin was used a biomarker of response and was reported to be significantly reduced following treatment with OGX-011, an antisense oligonucleotide against clusterin.
Gene_expression (expressed) of apolipoprotein J in colon associated with stress, colon cancer, prostate cancer, recurrence and disorder of lipid metabolism
12) Confidence 0.28 Published 2010 Journal OncoTargets and therapy Section Body Doc Link PMC2895780 Disease Relevance 1.00 Pain Relevance 0
Clusterin, also known as apolipoprotein J, is a stress-induced cyto-protective chaperone protein expressed in virtually all human tissues.10 Clusterin over-expression is demonstrated in various human malignancies including prostate, breast, lung, bladder, kidney, and colon cancers.11 In prostate cancer, clusterin levels are low in hormone-naïve tissue, but increase significantly after hormone therapy.12 Clusterin levels have also been correlated with preoperative PSA value and also the pathological grade on both biopsy and radical prostatectomy specimens.13 Further, clusterin expression has also been reported to be a possible predictor for biochemical recurrence following radical prostatectomy.14 In a recent phase II clinical trial,15 serum levels of clusterin was used a biomarker of response and was reported to be significantly reduced following treatment with OGX-011, an antisense oligonucleotide against clusterin.
Gene_expression (expression) of Clusterin in colon associated with stress, colon cancer, prostate cancer, recurrence and disorder of lipid metabolism
13) Confidence 0.25 Published 2010 Journal OncoTargets and therapy Section Body Doc Link PMC2895780 Disease Relevance 0.97 Pain Relevance 0
Clusterin is produced in numerous tissues during tissue injury or in disease states, and has also been shown to be produced by normal and arthritic chondrocytes [58].
Gene_expression (produced) of Clusterin in chondrocytes associated with injury, disease and arthritis
14) Confidence 0.19 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC1906814 Disease Relevance 0.88 Pain Relevance 0.23
Clusterin is produced in numerous tissues during tissue injury or in disease states, and has also been shown to be produced by normal and arthritic chondrocytes [58].
Gene_expression (produced) of Clusterin in chondrocytes associated with injury, disease and arthritis
15) Confidence 0.19 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC1906814 Disease Relevance 0.90 Pain Relevance 0.23
Clusterin, also known as apolipoprotein J, is a stress-induced cyto-protective chaperone protein expressed in virtually all human tissues.10 Clusterin over-expression is demonstrated in various human malignancies including prostate, breast, lung, bladder, kidney, and colon cancers.11 In prostate cancer, clusterin levels are low in hormone-naïve tissue, but increase significantly after hormone therapy.12 Clusterin levels have also been correlated with preoperative PSA value and also the pathological grade on both biopsy and radical prostatectomy specimens.13 Further, clusterin expression has also been reported to be a possible predictor for biochemical recurrence following radical prostatectomy.14 In a recent phase II clinical trial,15 serum levels of clusterin was used a biomarker of response and was reported to be significantly reduced following treatment with OGX-011, an antisense oligonucleotide against clusterin.
Gene_expression (expression) of clusterin in kidney associated with stress, colon cancer, prostate cancer, recurrence and disorder of lipid metabolism
16) Confidence 0.12 Published 2010 Journal OncoTargets and therapy Section Body Doc Link PMC2895780 Disease Relevance 0.86 Pain Relevance 0.03
Clusterin, also known as apolipoprotein J, is a stress-induced cyto-protective chaperone protein expressed in virtually all human tissues.10 Clusterin over-expression is demonstrated in various human malignancies including prostate, breast, lung, bladder, kidney, and colon cancers.11 In prostate cancer, clusterin levels are low in hormone-naïve tissue, but increase significantly after hormone therapy.12 Clusterin levels have also been correlated with preoperative PSA value and also the pathological grade on both biopsy and radical prostatectomy specimens.13 Further, clusterin expression has also been reported to be a possible predictor for biochemical recurrence following radical prostatectomy.14 In a recent phase II clinical trial,15 serum levels of clusterin was used a biomarker of response and was reported to be significantly reduced following treatment with OGX-011, an antisense oligonucleotide against clusterin.
Gene_expression (expression) of clusterin in lung associated with stress, colon cancer, prostate cancer, recurrence and disorder of lipid metabolism
17) Confidence 0.12 Published 2010 Journal OncoTargets and therapy Section Body Doc Link PMC2895780 Disease Relevance 0.86 Pain Relevance 0.03
Clusterin, also known as apolipoprotein J, is a stress-induced cyto-protective chaperone protein expressed in virtually all human tissues.10 Clusterin over-expression is demonstrated in various human malignancies including prostate, breast, lung, bladder, kidney, and colon cancers.11 In prostate cancer, clusterin levels are low in hormone-naïve tissue, but increase significantly after hormone therapy.12 Clusterin levels have also been correlated with preoperative PSA value and also the pathological grade on both biopsy and radical prostatectomy specimens.13 Further, clusterin expression has also been reported to be a possible predictor for biochemical recurrence following radical prostatectomy.14 In a recent phase II clinical trial,15 serum levels of clusterin was used a biomarker of response and was reported to be significantly reduced following treatment with OGX-011, an antisense oligonucleotide against clusterin.
Gene_expression (expression) of clusterin in bladder associated with stress, colon cancer, prostate cancer, recurrence and disorder of lipid metabolism
18) Confidence 0.12 Published 2010 Journal OncoTargets and therapy Section Body Doc Link PMC2895780 Disease Relevance 0.86 Pain Relevance 0.03
Clusterin, also known as apolipoprotein J, is a stress-induced cyto-protective chaperone protein expressed in virtually all human tissues.10 Clusterin over-expression is demonstrated in various human malignancies including prostate, breast, lung, bladder, kidney, and colon cancers.11 In prostate cancer, clusterin levels are low in hormone-naïve tissue, but increase significantly after hormone therapy.12 Clusterin levels have also been correlated with preoperative PSA value and also the pathological grade on both biopsy and radical prostatectomy specimens.13 Further, clusterin expression has also been reported to be a possible predictor for biochemical recurrence following radical prostatectomy.14 In a recent phase II clinical trial,15 serum levels of clusterin was used a biomarker of response and was reported to be significantly reduced following treatment with OGX-011, an antisense oligonucleotide against clusterin.
Gene_expression (over) of Clusterin in kidney associated with stress, colon cancer, prostate cancer, recurrence and disorder of lipid metabolism
19) Confidence 0.11 Published 2010 Journal OncoTargets and therapy Section Body Doc Link PMC2895780 Disease Relevance 0.97 Pain Relevance 0
Clusterin, also known as apolipoprotein J, is a stress-induced cyto-protective chaperone protein expressed in virtually all human tissues.10 Clusterin over-expression is demonstrated in various human malignancies including prostate, breast, lung, bladder, kidney, and colon cancers.11 In prostate cancer, clusterin levels are low in hormone-naïve tissue, but increase significantly after hormone therapy.12 Clusterin levels have also been correlated with preoperative PSA value and also the pathological grade on both biopsy and radical prostatectomy specimens.13 Further, clusterin expression has also been reported to be a possible predictor for biochemical recurrence following radical prostatectomy.14 In a recent phase II clinical trial,15 serum levels of clusterin was used a biomarker of response and was reported to be significantly reduced following treatment with OGX-011, an antisense oligonucleotide against clusterin.
Gene_expression (over) of Clusterin in bladder associated with stress, colon cancer, prostate cancer, recurrence and disorder of lipid metabolism
20) Confidence 0.11 Published 2010 Journal OncoTargets and therapy Section Body Doc Link PMC2895780 Disease Relevance 0.97 Pain Relevance 0

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