INT122996

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Context Info
Confidence 0.58
First Reported 2004
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 9
Total Number 11
Disease Relevance 1.53
Pain Relevance 0.34

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Rps6kb1) mitochondrion (Rps6kb1) aging (Rps6kb1)
nucleus (Rps6kb1) cell cycle (Rps6kb1) cytoplasm (Rps6kb1)
Anatomy Link Frequency
myocardium 4
dorsal 2
hypothalamus 2
skeletal muscle 2
Rps6kb1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Intracerebroventricular 25 88.08 High High
anesthesia 13 77.40 Quite High
Hippocampus 50 64.72 Quite High
Spinal cord 3 61.68 Quite High
Glutamate receptor 2 58.48 Quite High
agonist 5 48.28 Quite Low
long-term potentiation 18 24.16 Low Low
cytokine 14 5.00 Very Low Very Low Very Low
nalbuphine 3 5.00 Very Low Very Low Very Low
analgesia 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Shock 9 99.52 Very High Very High Very High
Coronary Heart Disease 3 98.52 Very High Very High Very High
Heart Rate Under Development 15 95.16 Very High Very High Very High
Stress 6 94.08 High High
Body Weight 21 83.12 Quite High
Obesity 195 76.88 Quite High
Appetite Loss 70 72.20 Quite High
Myocardial Infarction 6 25.84 Quite Low
Sepsis 9 5.00 Very Low Very Low Very Low
Aging 7 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We found that blockade of BDNF with function-blocking anti-BDNF antibodies delivered into dorsal CA1 15 min before training abolished the IA learning-induced increase in mTOR (Figure 5A) and p70S6K (Figure 5B) phosphorylation.
Positive_regulation (increase) of Phosphorylation (phosphorylation) of p70S6K in dorsal
1) Confidence 0.58 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2695538 Disease Relevance 0 Pain Relevance 0.06
45 h after training hindered the IA learning-induced increase in mTOR (Figure 5C) and p70S6K (Figure 5D) phosphorylation that takes place 3 h after training.
Positive_regulation (increase) of Phosphorylation (phosphorylation) of p70S6K
2) Confidence 0.42 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2695538 Disease Relevance 0 Pain Relevance 0.03
The expressions of heat shock protein 72 (58.0%) and phosphorylated p70S6 kinase (52.3%) were increased 1 day following heat exposure (p <0.05).
Positive_regulation (increased) of Phosphorylation (phosphorylated) of p70S6 kinase associated with shock
3) Confidence 0.40 Published 2004 Journal Jpn. J. Physiol. Section Abstract Doc Link 15541204 Disease Relevance 0.49 Pain Relevance 0.08
Firstly, elevated phosphorylation levels of residues Thr421 and Ser424 for p70 S6K were observed in the myocardium of LPS-treated rats. p70 S6K indirectly promotes the translation of target oligopyrimidine (TOP) mRNAs which are almost exclusively confined to transcripts that encode for ribosomal proteins and translation factors.
Positive_regulation (elevated) of Phosphorylation (phosphorylation) of p70 S6K in myocardium
4) Confidence 0.35 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2736646 Disease Relevance 0.17 Pain Relevance 0
6 M) to exercised rats pretreated with vehicle induced p70S6K and 4EBP1 phosphorylation in the hypothalamus of 60% and 70%, respectively, compared with the control group.
Positive_regulation (induced) of Phosphorylation (phosphorylation) of p70S6K in hypothalamus
5) Confidence 0.34 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2585815 Disease Relevance 0.05 Pain Relevance 0
-LA increased p70S6K and 4EBP1 threonine phosphorylation of 19% and 11%, respectively (Figures 4d and e). ?
Positive_regulation (increased) of Phosphorylation (phosphorylation) of p70S6K
6) Confidence 0.34 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2585815 Disease Relevance 0.05 Pain Relevance 0.07
Comparing fasting groups (control vs. exercise), exercised animals showed increases in p70S6K and 4EBP1 threonine phosphorylation of 261% and 240%, respectively (Figures 3n and o).
Positive_regulation (increases) of Phosphorylation (phosphorylation) of p70S6K
7) Confidence 0.34 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2585815 Disease Relevance 0.07 Pain Relevance 0.07
We also observed that the increased phosphorylations of p70S6K and 4EBP1, induced by exercise, were also reversed by antiĀ–IL-6 infusion (Figures 6e and f).
Positive_regulation (increased) of Phosphorylation (phosphorylations) of p70S6K
8) Confidence 0.34 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2585815 Disease Relevance 0.53 Pain Relevance 0
However, comparing AICAR treated groups (control vs. exercise), exercised animals showed increases in p70S6K and 4EBP1 threonine phosphorylation of 230% and 310%, respectively (Figures 3d and e).
Positive_regulation (increases) of Phosphorylation (phosphorylation) of p70S6K
9) Confidence 0.34 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2585815 Disease Relevance 0 Pain Relevance 0
In contrast, elevations in phosphorylation of p70 S6K residues Thr421/Ser424, and 4E-BP1 residues Thr37/Thr46 (P<0.05), consistent with an elevation in translation initiation, were seen exclusively in the myocardium of LPS-treated animals.


Positive_regulation (elevations) of Phosphorylation (phosphorylation) of p70 S6K in myocardium
10) Confidence 0.25 Published 2009 Journal PLoS ONE Section Abstract Doc Link PMC2736646 Disease Relevance 0 Pain Relevance 0
Contraction, at least in skeletal muscle, promotes the increased phosphorylation of p70 S6K [33] and is known to be involved in cardiac hypertrophy [34].
Positive_regulation (increased) of Phosphorylation (phosphorylation) of p70 S6K in skeletal muscle associated with coronary heart disease
11) Confidence 0.25 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2736646 Disease Relevance 0.18 Pain Relevance 0.03

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