INT122997

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Context Info
Confidence 0.72
First Reported 2004
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 46
Total Number 47
Disease Relevance 9.92
Pain Relevance 3.43

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Rps6kb1) mitochondrion (Rps6kb1) aging (Rps6kb1)
nucleus (Rps6kb1) cell cycle (Rps6kb1) cytoplasm (Rps6kb1)
Anatomy Link Frequency
hypothalamus 7
skin 4
myocardium 2
dorsal 1
nerve 1
Rps6kb1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Paracetamol 4 95.28 Very High Very High Very High
long-term potentiation 60 93.60 High High
calcitonin gene related peptide 10 88.32 High High
Intracerebroventricular 80 88.08 High High
Inflammatory response 10 86.72 High High
Sciatic nerve 50 85.04 High High
Calcitonin gene-related peptide 92 84.96 Quite High
Inflammation 42 79.28 Quite High
agonist 28 77.44 Quite High
anesthesia 47 77.40 Quite High
Disease Link Frequency Relevance Heat
Shock 25 99.52 Very High Very High Very High
Obesity 633 99.04 Very High Very High Very High
Hyperplasia 16 98.62 Very High Very High Very High
Coronary Heart Disease 6 98.52 Very High Very High Very High
Hyperinsulinism 4 97.72 Very High Very High Very High
Heart Rate Under Development 30 94.80 High High
Stress 22 92.66 High High
Neointima 44 91.60 High High
Injury 174 90.00 High High
Hyperglycemia 8 88.76 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
It was shown that rosiglitazone inhibits phosphorylation of the Akt-mTOR-P70S6K system in RAoSMCs stimulated with insulin.
Phosphorylation (phosphorylation) of mTOR-P70S6K
1) Confidence 0.72 Published 2008 Journal Yonsei Medical Journal Section Body Doc Link PMC2615285 Disease Relevance 1.02 Pain Relevance 0.03
To determine whether factors upstream of the Akt-mTOR-P70S6K system regulate phosphorylation of this system, inhibitors of upstream molecules were added to cells prior to treatment with insulin.
Phosphorylation (phosphorylation) of mTOR-P70S6K
2) Confidence 0.71 Published 2008 Journal Yonsei Medical Journal Section Body Doc Link PMC2615285 Disease Relevance 0.95 Pain Relevance 0.03
We found that blockade of BDNF with function-blocking anti-BDNF antibodies delivered into dorsal CA1 15 min before training abolished the IA learning-induced increase in mTOR (Figure 5A) and p70S6K (Figure 5B) phosphorylation.
Phosphorylation (phosphorylation) of p70S6K in dorsal
3) Confidence 0.68 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2695538 Disease Relevance 0 Pain Relevance 0.06
Rapamycin is a specific inhibitor of mTOR function that prevents p70S6K and 4E-BPs phosphorylation thus interfering with the initiation of translation [11] of a subset of mRNAs rather than general translation [12].
Phosphorylation (phosphorylation) of p70S6K
4) Confidence 0.68 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2695538 Disease Relevance 0 Pain Relevance 0.12
45 h after training hindered the IA learning-induced increase in mTOR (Figure 5C) and p70S6K (Figure 5D) phosphorylation that takes place 3 h after training.
Phosphorylation (phosphorylation) of p70S6K
5) Confidence 0.67 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2695538 Disease Relevance 0 Pain Relevance 0.03
L dose respectively of rapamycin attenuate the phosphorylation of p70S6K.
Phosphorylation (phosphorylation) of p70S6K
6) Confidence 0.64 Published 2010 Journal The Journal of Pain Section Body Doc Link PMC3000494 Disease Relevance 0.51 Pain Relevance 0.08
Leptin induced p70S6K and 4EBP1 threonine phosphorylation in the hypothalamus of control and exercised rats.
Phosphorylation (phosphorylation) of p70S6K in hypothalamus
7) Confidence 0.56 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2585815 Disease Relevance 0.07 Pain Relevance 0.03
-LA increased p70S6K and 4EBP1 threonine phosphorylation of 19% and 11%, respectively (Figures 4d and e). ?
Phosphorylation (phosphorylation) of p70S6K
8) Confidence 0.56 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2585815 Disease Relevance 0.05 Pain Relevance 0.07
However, comparing AICAR treated groups (control vs. exercise), exercised animals showed increases in p70S6K and 4EBP1 threonine phosphorylation of 230% and 310%, respectively (Figures 3d and e).
Phosphorylation (phosphorylation) of p70S6K
9) Confidence 0.56 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2585815 Disease Relevance 0 Pain Relevance 0
AICAR reduced p70S6K and 4EBP1 threonine phosphorylation levels in the hypothalamus of control and exercised rats.
Phosphorylation (phosphorylation) of p70S6K in hypothalamus
10) Confidence 0.56 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2585815 Disease Relevance 0 Pain Relevance 0.03
Comparing leptin treated groups (control vs. exercise), in exercised animals, leptin increased both p70S6K and 4EBP1 threonine phosphorylation of 30% and 40% respectively (Figures 5d and e).
Phosphorylation (phosphorylation) of p70S6K
11) Confidence 0.56 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2585815 Disease Relevance 0.09 Pain Relevance 0
We also observed that the increased phosphorylations of p70S6K and 4EBP1, induced by exercise, were also reversed by antiĀ–IL-6 infusion (Figures 6e and f).
Phosphorylation (phosphorylations) of p70S6K
12) Confidence 0.56 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2585815 Disease Relevance 0.53 Pain Relevance 0
Exercised animals pretreated with Rapamycin also reduced hypothalamic p70S6K and 4EBP1 phosphorylation (Figures 8d and e).
Phosphorylation (phosphorylation) of p70S6K
13) Confidence 0.56 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2585815 Disease Relevance 0 Pain Relevance 0
6 M) to exercised rats pretreated with vehicle induced p70S6K and 4EBP1 phosphorylation in the hypothalamus of 60% and 70%, respectively, compared with the control group.
Phosphorylation (phosphorylation) of p70S6K in hypothalamus
14) Confidence 0.56 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2585815 Disease Relevance 0.05 Pain Relevance 0
Comparing fasting groups (control vs. exercise), exercised animals showed increases in p70S6K and 4EBP1 threonine phosphorylation of 261% and 240%, respectively (Figures 3n and o).
Phosphorylation (phosphorylation) of p70S6K
15) Confidence 0.56 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2585815 Disease Relevance 0.07 Pain Relevance 0.07
To determine the effects of exercise on AMPK-mTOR signaling pathway, leptin was i.c.v. administered and AMPK, ACC, p70S6K and 4EBP1 phosphorylation levels were assessed in the hypothalamus of all rats.
Phosphorylation (phosphorylation) of p70S6K in hypothalamus
16) Confidence 0.56 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2585815 Disease Relevance 0 Pain Relevance 0.03
Tyramide Signal Amplification (phospho p70S6K)
Phosphorylation (phospho) of p70S6K
17) Confidence 0.55 Published 2010 Journal The Journal of Pain Section Body Doc Link PMC3000494 Disease Relevance 0 Pain Relevance 0.06
Insulin induces increased expression of translation initiation factors and phosphorylation of 4EBP-1 and S6K, critical cell cycle regulators downstream of mTOR.
Phosphorylation (phosphorylation) of S6K
18) Confidence 0.55 Published 2008 Journal Yonsei Medical Journal Section Body Doc Link PMC2615285 Disease Relevance 0.64 Pain Relevance 0.04
We used insulin as a mitogenic stimulus because of the important role of hyperinsulinemia in the development of neointimal hyperplasia, the concomitant inducer of translation initiation factor activity (phosphorylation of 4EBP-1 and P70S6K), and critical cell cycle regulators downstream of mTOR.
Phosphorylation (phosphorylation) of P70S6K associated with hyperinsulinism and hyperplasia
19) Confidence 0.55 Published 2008 Journal Yonsei Medical Journal Section Body Doc Link PMC2615285 Disease Relevance 0.38 Pain Relevance 0.09
The expressions of heat shock protein 72 (58.0%) and phosphorylated p70S6 kinase (52.3%) were increased 1 day following heat exposure (p <0.05).
Phosphorylation (phosphorylated) of p70S6 kinase associated with shock
20) Confidence 0.54 Published 2004 Journal Jpn. J. Physiol. Section Abstract Doc Link 15541204 Disease Relevance 0.49 Pain Relevance 0.08

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