INT122999

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Context Info
Confidence 0.67
First Reported 2004
Last Reported 2009
Negated 1
Speculated 1
Reported most in Body
Documents 16
Total Number 17
Disease Relevance 3.45
Pain Relevance 0.71

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Rps6kb1) mitochondrion (Rps6kb1) aging (Rps6kb1)
nucleus (Rps6kb1) cell cycle (Rps6kb1) cytoplasm (Rps6kb1)
Anatomy Link Frequency
hypothalamus 2
bands 2
myocardium 1
arcuate nucleus 1
Rps6kb1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Intracerebroventricular 20 97.44 Very High Very High Very High
Calcitonin gene-related peptide 36 95.24 Very High Very High Very High
Sciatic nerve 20 91.28 High High
Inflammation 24 81.24 Quite High
anesthesia 15 79.36 Quite High
nociceptor 164 79.04 Quite High
unmyelinated 16 50.12 Quite High
withdrawal 60 40.68 Quite Low
Inflammatory response 4 22.72 Low Low
agonist 16 15.04 Low Low
Disease Link Frequency Relevance Heat
Shock 1 100.00 Very High Very High Very High
Obesity 165 98.80 Very High Very High Very High
Injury 104 96.88 Very High Very High Very High
Stress 9 92.24 High High
Hyperglycemia 8 90.72 High High
Diabetes Mellitus 36 90.00 High High
Appetite Loss 61 89.44 High High
Vasculitis 8 87.60 High High
Body Weight 34 85.08 High High
Hyperplasia 16 84.56 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The expressions of heat shock protein 72 (58.0%) and phosphorylated p70S6 kinase (52.3%) were increased 1 day following heat exposure (p <0.05).
Gene_expression (expressions) of p70S6 kinase associated with shock
1) Confidence 0.67 Published 2004 Journal Jpn. J. Physiol. Section Abstract Doc Link 15541204 Disease Relevance 0.50 Pain Relevance 0.08
Akt-mTOR-P70S6K signaling pathway in RAoSMCs treated with rosiglitazone
Gene_expression (pathway) of mTOR-P70S6K
2) Confidence 0.59 Published 2008 Journal Yonsei Medical Journal Section Body Doc Link PMC2615285 Disease Relevance 0.49 Pain Relevance 0
AMPK, ACC, p70S6K and 4EBP1 protein expression (Figures 4b–e, lower panels).


Gene_expression (expression) of p70S6K
3) Confidence 0.53 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2585815 Disease Relevance 0 Pain Relevance 0.07
The expression of p-P70S6K after rosiglitazone administration was assessed before and after treatment with MEK inhibitor U0126 (10 µM) and PI3K inhibitor wortmannin (10 µM).
Gene_expression (expression) of P70S6K
4) Confidence 0.53 Published 2008 Journal Yonsei Medical Journal Section Body Doc Link PMC2615285 Disease Relevance 0.47 Pain Relevance 0
Insulin induces increased expression of translation initiation factors and phosphorylation of 4EBP-1 and S6K, critical cell cycle regulators downstream of mTOR.
Gene_expression (expression) of S6K
5) Confidence 0.53 Published 2008 Journal Yonsei Medical Journal Section Body Doc Link PMC2615285 Disease Relevance 0.65 Pain Relevance 0.04
Inhibition of both MEK and PI3K resulted in partial reduction of p-P70S6K expression that was associated with additional inhibition, indicating that both the MAPK and PI3K pathways have an effect on the activation of the Akt-mTOR-P70S6K system.


Gene_expression (expression) of P70S6K
6) Confidence 0.53 Published 2008 Journal Yonsei Medical Journal Section Body Doc Link PMC2615285 Disease Relevance 0.41 Pain Relevance 0.03
The p70S6K and 4EBP1 protein levels were not different between the groups (Figures 7e and f, lower panels).


Gene_expression (levels) of p70S6K
7) Confidence 0.46 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2585815 Disease Relevance 0.72 Pain Relevance 0
6 M) to rats pretreated with AICAR reduced both p70S6K and 4EBP1 phosphorylation levels in the hypothalamus.
Gene_expression (levels) of p70S6K in hypothalamus
8) Confidence 0.46 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2585815 Disease Relevance 0 Pain Relevance 0
Activation of hypothalamic mTOR or increased expression of S6K in the mediobasal hypothalamus results in decreased feeding [12], [32]; therefore, Sirt1 down-regulating S6K signaling fits our model on the regulation of energy balance by hypothalamic Sirt1.
Gene_expression (expression) of S6K in hypothalamus
9) Confidence 0.37 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2790615 Disease Relevance 0.06 Pain Relevance 0
The immunoreactivity of IL-6R and pp70S6K was not detected in the hypothalamic arcuate nucleus of rats after i.c.v. saline infusion.
Neg (not) Gene_expression (detected) of pp70S6K in arcuate nucleus
10) Confidence 0.36 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2585815 Disease Relevance 0.15 Pain Relevance 0
Phospho-S6K was extensively expressed in approximately 42±2.1 % of N52- positive fibers (N?
Gene_expression (expressed) of S6K
11) Confidence 0.35 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2276314 Disease Relevance 0 Pain Relevance 0.41
Single or double bands of appropriate molecular weight were found for mTOR, phospho-mTOR, phospho-S6K, phospho-4E-BP1/2 and phospho-S6.


Gene_expression (/) of S6K in bands
12) Confidence 0.35 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2276314 Disease Relevance 0 Pain Relevance 0.04
The frequency of distribution of the normalised phospho-S6K pixel intensities was expressed as percentage of pixels above the arbitrary value of 50.
Gene_expression (expressed) of S6K
13) Confidence 0.35 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2276314 Disease Relevance 0 Pain Relevance 0
In contrast, elevations in phosphorylation of p70 S6K residues Thr421/Ser424, and 4E-BP1 residues Thr37/Thr46 (P<0.05), consistent with an elevation in translation initiation, were seen exclusively in the myocardium of LPS-treated animals.


Gene_expression (residues) of p70 S6K in myocardium
14) Confidence 0.34 Published 2009 Journal PLoS ONE Section Abstract Doc Link PMC2736646 Disease Relevance 0 Pain Relevance 0
Single or double bands of appropriate molecular weight were found for mTOR, phospho-mTOR, phospho-S6K, phospho-4E-BP1/2 and phospho-S6.


Gene_expression (/) of S6 in bands
15) Confidence 0.31 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2276314 Disease Relevance 0 Pain Relevance 0.04
Furthermore, while levels of p70 S6K and 4E-BP1 were not examined as part of the previous study, phosphorylation of other downstream targets of AKT kinase activity, namely Foxo1 and Foxo3, were shown to be similarly reduced.
Spec (examined) Gene_expression (levels) of p70 S6K
16) Confidence 0.30 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2736646 Disease Relevance 0 Pain Relevance 0
Protein and phosphorylation levels of AKT, p70 S6K and 4E-BP1
Gene_expression (levels) of p70 S6K
17) Confidence 0.13 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2736646 Disease Relevance 0 Pain Relevance 0

General Comments

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