INT123031

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Context Info
Confidence 0.42
First Reported 2004
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 1.01
Pain Relevance 0.09

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

lysosome (Sgsh)
Sgsh (Mus musculus)
Sgsh - V131M (1)
Pain Link Frequency Relevance Heat
anesthesia 1 94.16 High High
Potency 2 11.76 Low Low
Calcium channel 7 5.84 Low Low
Central nervous system 7 5.00 Very Low Very Low Very Low
TRP channel 3 5.00 Very Low Very Low Very Low
antagonist 3 5.00 Very Low Very Low Very Low
fibrosis 2 5.00 Very Low Very Low Very Low
addiction 2 5.00 Very Low Very Low Very Low
Glutamate receptor 2 5.00 Very Low Very Low Very Low
Angina 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Lysosome Storage Disease 8 98.86 Very High Very High Very High
Mucopolysaccharidoses 11 97.72 Very High Very High Very High
Disease 11 96.40 Very High Very High Very High
Disease Progression 1 83.44 Quite High
Lysosomal Storage Diseases 24 73.20 Quite High
Neuropathic Pain 9 27.28 Quite Low
Gauchers Disease 11 26.32 Quite Low
Hypertension 2 5.00 Very Low Very Low Very Low
Cystic Fibrosis 2 5.00 Very Low Very Low Very Low
Anaemia 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Mucopolysaccharidosis type IIIA (MPS IIIA) is a lysosomal storage disorder caused by a deficiency in the lysosomal enzyme sulfamidase, which is required for the degradation of heparan sulfate.
Positive_regulation (required) of sulfamidase associated with lysosome storage disease
1) Confidence 0.42 Published 2004 Journal Mol. Genet. Metab. Section Abstract Doc Link 15542395 Disease Relevance 0.46 Pain Relevance 0.09
M) treatment increased S66W/V131M sulfamidase activity up to 2.1-fold and 1.9-fold (?
Positive_regulation (increased) of sulfamidase (V131M)
2) Confidence 0.03 Published 2008 Journal PLoS Biology Section Body Doc Link PMC2225441 Disease Relevance 0.56 Pain Relevance 0

General Comments

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