INT123035

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Context Info
Confidence 0.78
First Reported 2004
Last Reported 2010
Negated 2
Speculated 3
Reported most in Body
Documents 38
Total Number 41
Disease Relevance 28.84
Pain Relevance 27.32

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endosome (Ephb1) signal transduction (Ephb1) cell adhesion (Ephb1)
plasma membrane (Ephb1) kinase activity (Ephb1) cytoplasm (Ephb1)
Anatomy Link Frequency
neurons 4
paw 3
brain 2
midline 2
retina 1
Ephb1 (Mus musculus)
Pain Link Frequency Relevance Heat
Serotonin 242 100.00 Very High Very High Very High
fluoxetine 74 100.00 Very High Very High Very High
B1 receptor 63 100.00 Very High Very High Very High
Hippocampus 14 99.92 Very High Very High Very High
Desipramine 49 99.84 Very High Very High Very High
addiction 649 99.48 Very High Very High Very High
hyperexcitability 205 99.44 Very High Very High Very High
Opioid 108 99.40 Very High Very High Very High
Thermal hyperalgesia 350 99.30 Very High Very High Very High
opiate 255 99.08 Very High Very High Very High
Disease Link Frequency Relevance Heat
Morphine Dependence 459 99.48 Very High Very High Very High
Hyperalgesia 753 99.30 Very High Very High Very High
Neuropathic Pain 812 99.24 Very High Very High Very High
Pain 759 99.04 Very High Very High Very High
Targeted Disruption 299 99.00 Very High Very High Very High
Ganglion Cysts 176 98.90 Very High Very High Very High
Cancer 532 98.78 Very High Very High Very High
Drug Dependence 72 98.68 Very High Very High Very High
Handedness 84 98.52 Very High Very High Very High
Nervous System Injury 453 98.48 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The ephrinB-EphB interaction is well known to lead bidirectional signals which are propagated into the ephrinB-expressing cells (reverse signaling) and the EphB-expressing cells (forward signaling).
Gene_expression (expressing) of EphB
1) Confidence 0.78 Published 2008 Journal Mol Pain Section Body Doc Link PMC2605438 Disease Relevance 1.00 Pain Relevance 0.80
This result further suggests that a proper expression levels of the WT EphB1 receptor (EphB1+/+) is necessary for development of neuropathic hyperalgesia, and that reduction to approximately 50% normal levels in heterozygous mice sufficient to prevent this form occurring.


Gene_expression (expression) of EphB1 associated with hyperalgesia and neuropathic pain
2) Confidence 0.78 Published 2008 Journal Mol Pain Section Body Doc Link PMC2605438 Disease Relevance 1.27 Pain Relevance 1.06
This result further suggests that a proper expression levels of the WT EphB1 receptor (EphB1+/+) is necessary for development of neuropathic hyperalgesia, and that reduction to approximately 50% normal levels in heterozygous mice sufficient to prevent this form occurring.


Gene_expression (expression) of EphB1 associated with hyperalgesia and neuropathic pain
3) Confidence 0.78 Published 2008 Journal Mol Pain Section Body Doc Link PMC2605438 Disease Relevance 1.28 Pain Relevance 1.06
The present study aimed to elucidate whether chronic treatment with desipramine regulates the expression of NET protein examined in membrane fractions in various brain regions and whether co-administration of local anesthetics affects the desipramine-induced alteration of NET expression.
Gene_expression (expression) of NET in brain associated with desipramine and local anesthetic
4) Confidence 0.78 Published 2008 Journal Neurochem. Int. Section Abstract Doc Link 17981365 Disease Relevance 0.08 Pain Relevance 1.01
NET protein expression in the whole cell fraction and membrane fraction was not affected by treatment with any drugs.
Gene_expression (expression) of NET protein
5) Confidence 0.78 Published 2008 Journal Neurochem. Int. Section Abstract Doc Link 17981365 Disease Relevance 0.05 Pain Relevance 1.11
Nerve injury-induced DRG neuron hyperexcitability are prevented or largely diminished in EphB1-/- and EphB1+/- mice
Gene_expression (/) of EphB1 in neuron associated with nervous system injury and hyperexcitability
6) Confidence 0.68 Published 2008 Journal Mol Pain Section Body Doc Link PMC2605438 Disease Relevance 0.97 Pain Relevance 0.73
The forward signaling of EphB1 receptor is involved in development of neuropathic hyperalgesia and morphine dependence
Gene_expression (receptor) of EphB1 associated with addiction, hyperalgesia, neuropathic pain and morphine
7) Confidence 0.68 Published 2008 Journal Mol Pain Section Body Doc Link PMC2605438 Disease Relevance 1.19 Pain Relevance 0.90
The time courses and changes of thermal sensitivity in EphB1+/+, EphB1+/- and EphB1-/- mice are shown in Fig. 3B.
Gene_expression (/) of EphB1
8) Confidence 0.68 Published 2008 Journal Mol Pain Section Body Doc Link PMC2605438 Disease Relevance 1.01 Pain Relevance 0.69
However, CCI treatment did not significantly alter these properties of the DRG neurons from EphB1+/- and EphB1-/- mice.
Gene_expression (/) of EphB1 in neurons
9) Confidence 0.68 Published 2008 Journal Mol Pain Section Body Doc Link PMC2605438 Disease Relevance 0.79 Pain Relevance 0.75
The time courses and changes of thermal sensitivity in EphB1+/+, EphB1+/- and EphB1-/- mice are shown in Fig. 3B.
Gene_expression (/) of EphB1
10) Confidence 0.68 Published 2008 Journal Mol Pain Section Body Doc Link PMC2605438 Disease Relevance 1.01 Pain Relevance 0.70
The time courses and changes of thermal sensitivity in EphB1+/+, EphB1+/- and EphB1-/- mice are shown in Fig. 3B.
Gene_expression (/) of EphB1
11) Confidence 0.68 Published 2008 Journal Mol Pain Section Body Doc Link PMC2605438 Disease Relevance 1.01 Pain Relevance 0.70
The ephrinB-EphB interaction is well known to lead bidirectional signals which are propagated into the ephrinB-expressing cells (reverse signaling) and the EphB-expressing cells (forward signaling).
Gene_expression (expressing) of EphB
12) Confidence 0.68 Published 2008 Journal Mol Pain Section Body Doc Link PMC2605438 Disease Relevance 1.06 Pain Relevance 0.81
EphrinB1-Fc evokes thermal hyperalgesia in EphB1+/+, but not EphB1-/- and EphB1+/- mice
Gene_expression (/) of EphB1 associated with thermal hyperalgesia
13) Confidence 0.68 Published 2008 Journal Mol Pain Section Body Doc Link PMC2605438 Disease Relevance 0.65 Pain Relevance 0.54
Nerve injury-induced DRG neuron hyperexcitability are prevented or largely diminished in EphB1-/- and EphB1+/- mice
Gene_expression (/) of EphB1 in neuron associated with nervous system injury and hyperexcitability
14) Confidence 0.68 Published 2008 Journal Mol Pain Section Body Doc Link PMC2605438 Disease Relevance 0.97 Pain Relevance 0.73
Roles of the reverse signaling of EphB1 receptor in development of neuropathic hyperalgesia and morphine dependence
Gene_expression (receptor) of EphB1 associated with addiction, hyperalgesia, neuropathic pain and morphine
15) Confidence 0.68 Published 2008 Journal Mol Pain Section Body Doc Link PMC2605438 Disease Relevance 1.64 Pain Relevance 1.37
If so, loss of postsynaptic EphB1 receptor in the EphB1-/- mice may result in loss of reverse signaling and therefore the subsequent activities.
Gene_expression (receptor) of EphB1
16) Confidence 0.68 Published 2008 Journal Mol Pain Section Body Doc Link PMC2605438 Disease Relevance 1.24 Pain Relevance 1.16
However, CCI treatment did not significantly alter these properties of the DRG neurons from EphB1+/- and EphB1-/- mice.
Gene_expression (/) of EphB1 in neurons
17) Confidence 0.68 Published 2008 Journal Mol Pain Section Body Doc Link PMC2605438 Disease Relevance 0.84 Pain Relevance 0.75
EphB receptors continue to be expressed (at lower levels) in the adult nervous system and, after neural injury [28,29] or prolonged MOR activation [27].
Gene_expression (expressed) of EphB in adult nervous system associated with injury and opioid receptor
18) Confidence 0.60 Published 2008 Journal Mol Pain Section Body Doc Link PMC2605438 Disease Relevance 0.86 Pain Relevance 1.14
The generation of EphB1 receptor protein-null mutant mice has been previously described [75,76].
Gene_expression (generation) of EphB1
19) Confidence 0.60 Published 2008 Journal Mol Pain Section Body Doc Link PMC2605438 Disease Relevance 1.11 Pain Relevance 1.28
The generation of EphB1 receptor protein-null mutant mice has been previously described [51,52].
Gene_expression (generation) of EphB1
20) Confidence 0.57 Published 2009 Journal Mol Pain Section Body Doc Link PMC2704201 Disease Relevance 0.56 Pain Relevance 0.86

General Comments

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