INT123045

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Context Info
Confidence 0.46
First Reported 2004
Last Reported 2007
Negated 0
Speculated 1
Reported most in Body
Documents 9
Total Number 10
Disease Relevance 5.73
Pain Relevance 5.77

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (Prkca) endoplasmic reticulum (Prkca) enzyme binding (Prkca)
protein complex (Prkca) cytoplasm (Prkca) cytosol (Prkca)
Anatomy Link Frequency
neurons 4
neuronal 2
peritoneal macrophages 2
Prkca (Mus musculus)
Pain Link Frequency Relevance Heat
Kinase C 449 100.00 Very High Very High Very High
qutenza 31 98.40 Very High Very High Very High
Neurotransmitter 30 96.80 Very High Very High Very High
opioid receptor 2 96.32 Very High Very High Very High
Analgesic 1 93.92 High High
Inflammation 59 93.76 High High
tolerance 10 93.12 High High
long-term potentiation 40 92.08 High High
agonist 11 91.92 High High
bradykinin 1 90.72 High High
Disease Link Frequency Relevance Heat
Virus Diseases 470 99.98 Very High Very High Very High
Infection 125 99.44 Very High Very High Very High
Aging 103 97.48 Very High Very High Very High
Hypersensitivity 5 95.56 Very High Very High Very High
Injury 22 94.56 High High
INFLAMMATION 71 93.76 High High
Acquired Immune Deficiency Syndrome Or Hiv Infection 12 92.24 High High
Pain 13 88.84 High High
Nociception 31 84.24 Quite High
Ganglion Cysts 26 83.36 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Interestingly, inhibition of the phosphorylation of endogenous PKC substrates was also observed after transfection of neurons with BDV P.
Negative_regulation (inhibition) of Phosphorylation (phosphorylation) of PKC in neurons associated with virus diseases and kinase c
1) Confidence 0.46 Published 2006 Journal PLoS Pathogens Section Body Doc Link PMC1401496 Disease Relevance 0.61 Pain Relevance 0.72
PKC phosphorylation inhibits endocytosis (PKC hypothesis).
Negative_regulation (inhibits) of Phosphorylation (phosphorylation) of PKC associated with kinase c
2) Confidence 0.36 Published 2004 Journal Ann. N. Y. Acad. Sci. Section Abstract Doc Link 15542739 Disease Relevance 0.07 Pain Relevance 1.23
Thus, we hypothesized that P could compete with the phosphorylation of endogenous PKC substrates.
Negative_regulation (compete) of Phosphorylation (phosphorylation) of PKC associated with kinase c
3) Confidence 0.34 Published 2006 Journal PLoS Pathogens Section Body Doc Link PMC1401496 Disease Relevance 0.92 Pain Relevance 0.57
It is conceivable that the activity of PKC depends on the accessibility and the concentration of its substrates in the cell, and we postulate that the accumulation of a viral protein that can serve as a substrate for PKC may compete with the phosphorylation of endogenous PKC targets.
Spec (may) Negative_regulation (compete) of Phosphorylation (phosphorylation) of PKC associated with kinase c
4) Confidence 0.34 Published 2006 Journal PLoS Pathogens Section Body Doc Link PMC1401496 Disease Relevance 0.63 Pain Relevance 0.57
In contrast, the phosphorylation of myristoylated alanine-rich C kinase substrate (MARCKS), a major PKC substrate in neurons [31], was severely impaired in BDV-infected neurons following treatment with glycine (Figure 4D).
Negative_regulation (impaired) of Phosphorylation (phosphorylation) of PKC in neurons associated with virus diseases and kinase c
5) Confidence 0.34 Published 2006 Journal PLoS Pathogens Section Body Doc Link PMC1401496 Disease Relevance 0.85 Pain Relevance 0.21
Rather, BDV blocked the phosphorylation of PKC neuronal substrates, such as MARCKS and Munc18, which play essential roles in vesicular cycling.
Negative_regulation (blocked) of Phosphorylation (phosphorylation) of PKC in neuronal associated with virus diseases and kinase c
6) Confidence 0.34 Published 2006 Journal PLoS Pathogens Section Body Doc Link PMC1401496 Disease Relevance 0.78 Pain Relevance 0.68
In contrast to liver cells, coexposure to Pb+LPS significantly stimulated p42/44 MAPK phosphorylation in peritoneal macrophages; suppressing p42/44 MAPK phosphorylation or inhibiting PKC activity resulted in reduced TNF-?
Negative_regulation (suppressing) of Phosphorylation (phosphorylation) of PKC in peritoneal macrophages associated with kinase c
7) Confidence 0.23 Published 2006 Journal Environ Health Perspect Section Body Doc Link PMC1440772 Disease Relevance 0.19 Pain Relevance 0.23
Protein kinase C (PKC)-mediated phosphorylation of nascent chains at Thr-35 vastly decreased affinity for SRP binding suggesting an important regulatory step.
Negative_regulation (decreased) of Phosphorylation (phosphorylation) of PKC associated with kinase c
8) Confidence 0.21 Published 2006 Journal J. Biol. Chem. Section Abstract Doc Link 16899466 Disease Relevance 0 Pain Relevance 0.26
TRPV1 can be sensitized by phosphorylation through PKC, PKA and Ca2+/CaM-dependent kinsase II [17-20].
Negative_regulation (sensitized) of Phosphorylation (phosphorylation) of PKC
9) Confidence 0.11 Published 2006 Journal Mol Pain Section Body Doc Link PMC1660571 Disease Relevance 1.37 Pain Relevance 1.14
There is a decrease in the early tyrosine phosphorylation and generation of second messengers, calcium mobilization, and the translocation to the membrane of PKC.
Negative_regulation (decrease) of Phosphorylation (phosphorylation) of PKC associated with kinase c
10) Confidence 0.07 Published 2007 Journal Clinical Interventions in Aging Section Body Doc Link PMC2684090 Disease Relevance 0.31 Pain Relevance 0.17

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