INT123076

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.37
First Reported 2001
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 7
Total Number 7
Disease Relevance 1.91
Pain Relevance 1.56

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (Cacna1c) plasma membrane (Cacna1c) nucleus (Cacna1c)
transmembrane transport (Cacna1c) cytoplasm (Cacna1c)
Anatomy Link Frequency
neurons 1
brain 1
Cacna1c (Mus musculus)
Pain Link Frequency Relevance Heat
Calcium channel 2 100.00 Very High Very High Very High
antagonist 25 99.96 Very High Very High Very High
Morphine 7 98.64 Very High Very High Very High
addiction 40 92.88 High High
Physical dependence 3 90.36 High High
opioid receptor 1 87.28 High High
Nicotine 2 82.00 Quite High
cerebral cortex 4 79.92 Quite High
withdrawal 4 75.44 Quite High
alcohol 1 73.52 Quite High
Disease Link Frequency Relevance Heat
Scrapie 56 99.36 Very High Very High Very High
Congenital Anomalies 6 95.24 Very High Very High Very High
Creutzfeldt Jakob Disease 34 91.92 High High
Drug Dependence 9 90.36 High High
Disease 4 76.80 Quite High
Opiate Addiction 3 75.44 Quite High
Substance Withdrawal Syndrome 1 71.32 Quite High
Anxiety Disorder 2 68.92 Quite High
Sprains And Strains 38 64.04 Quite High
Overactive Bladder 32 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Regional differences of L-type high voltage-gated calcium channel subunit expression in the mouse brain after chronic morphine treatment.
Gene_expression (expression) of L-type in brain associated with calcium channel and morphine
1) Confidence 0.37 Published 2007 Journal J. Pharmacol. Sci. Section Title Doc Link 17917366 Disease Relevance 0.16 Pain Relevance 0.66
Sustained exposure of the neurons to abused drugs significantly increased the KCl (30 mM)-induced 45Ca2+ influx and enhanced expression of alpha1 subunits for L-type high voltage-gated Ca2+ channels (HVCCs).
Gene_expression (expression) of L-type in neurons
2) Confidence 0.07 Published 2004 Journal Ann. N. Y. Acad. Sci. Section Abstract Doc Link 15542765 Disease Relevance 0.73 Pain Relevance 0.73
These results, with the exception of the change in Ca2+ current density, are in remarkable agreement with those obtained when L-type Ca2+ channel subunits are coexpressed without the ?
Neg (without) Gene_expression (coexpressed) of L-type
3) Confidence 0.07 Published 2001 Journal BMC Physiol Section Body Doc Link PMC37314 Disease Relevance 0 Pain Relevance 0.05
The density of the L-type Ca2+ current in ?
Gene_expression (current) of L-type
4) Confidence 0.06 Published 2001 Journal BMC Physiol Section Abstract Doc Link PMC37314 Disease Relevance 0.10 Pain Relevance 0.03
The L-type Ca2+ channel antagonist nifedipine (1 ?
Gene_expression (The) of L-type associated with antagonist
5) Confidence 0.03 Published 2008 Journal The Journal of Physiology Section Body Doc Link PMC2655397 Disease Relevance 0 Pain Relevance 0.05
The L-type Ca2+ channel antagonist nifedipine (1 ?
Gene_expression (channel) of L-type associated with antagonist
6) Confidence 0.03 Published 2008 Journal The Journal of Physiology Section Body Doc Link PMC2655397 Disease Relevance 0 Pain Relevance 0.05
This result is consistent with the previous report, that the l-type PrPSc could be present in a number of scrapie sources [18].
Gene_expression (present) of l-type associated with scrapie
7) Confidence 0.01 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2982847 Disease Relevance 0.93 Pain Relevance 0

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox