INT123078

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Context Info
Confidence 0.10
First Reported 2004
Last Reported 2005
Negated 0
Speculated 0
Reported most in Abstract
Documents 2
Total Number 2
Disease Relevance 0.87
Pain Relevance 1.09

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (Kcnj1) plasma membrane (Kcnj1)
Kcnj1 (Mus musculus)
Pain Link Frequency Relevance Heat
sSRI 4 99.00 Very High Very High Very High
antinociception 1 91.60 High High
fluoxetine 3 90.28 High High
Opioid 4 90.08 High High
Cannabinoid 4 89.36 High High
cocaine 2 86.96 High High
antidepressant 2 81.28 Quite High
dopamine receptor 1 65.52 Quite High
Neuronal excitability 1 59.48 Quite High
Pain 1 50.48 Quite High
Disease Link Frequency Relevance Heat
Bartter Syndrome 3 98.56 Very High Very High Very High
Acidosis 1 97.24 Very High Very High Very High
Diabetes Mellitus 1 97.00 Very High Very High Very High
Hypomagnesemia 1 95.68 Very High Very High Very High
Hypocalcemia 2 94.92 High High
Convulsion 3 93.52 High High
Targeted Disruption 7 83.44 Quite High
Nonsyndromic Deafness 1 60.08 Quite High
Diabetes Insipidus 1 57.12 Quite High
Cystic Fibrosis 7 43.04 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Functional loss of NKCC, Kir1.1, ClC-Kb or Barttin is a cause of Bartter syndrome, in which nephrogenic diabetes insipides, hypokalemia, hypomagnesemia and hypocalcemia have been observed as variations in phenotype [82–84].
Negative_regulation (loss) of Kir1 associated with hypomagnesemia, hypocalcemia, diabetes mellitus and bartter syndrome
1) Confidence 0.10 Published 2005 Journal Cell Mol Life Sci Section Body Doc Link PMC2792346 Disease Relevance 0.70 Pain Relevance 0
In contrast, Kir1.1 and Kir2.1 channels were insensitive to ethanol and various SSRIs and antipsychotics, although thioridazine weakly inhibited Kir1.1 channels.
Negative_regulation (inhibited) of Kir1 associated with ssri
2) Confidence 0.01 Published 2004 Journal Ann. N. Y. Acad. Sci. Section Abstract Doc Link 15542767 Disease Relevance 0.18 Pain Relevance 1.09

General Comments

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