INT1231

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Context Info
Confidence 0.35
First Reported 1976
Last Reported 2006
Negated 0
Speculated 1
Reported most in Abstract
Documents 6
Total Number 7
Disease Relevance 1.88
Pain Relevance 4.13

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Pdpk1) cytoplasmic membrane-bounded vesicle (Pdpk1) plasma membrane (Pdpk1)
nucleus (Pdpk1) kinase activity (Pdpk1) cytoplasm (Pdpk1)
Anatomy Link Frequency
spinal cord 4
liver 2
Pdpk1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Kinase C 6 100.00 Very High Very High Very High
nMDA receptor antagonist 4 99.98 Very High Very High Very High
gABA 3 99.68 Very High Very High Very High
Morphine 9 98.80 Very High Very High Very High
Spinal cord 10 97.32 Very High Very High Very High
narcan 5 97.16 Very High Very High Very High
antagonist 7 96.84 Very High Very High Very High
Glutamate receptor 2 96.40 Very High Very High Very High
local anesthetic 4 96.20 Very High Very High Very High
Sciatic nerve 1 94.36 High High
Disease Link Frequency Relevance Heat
INFLAMMATION 17 93.04 High High
Nociception 3 82.04 Quite High
Pain 3 78.16 Quite High
Nervous System Injury 3 75.00 Quite High
Neuropathic Pain 1 69.72 Quite High
Hyperalgesia 8 64.16 Quite High
Injury 3 59.44 Quite High
Morphine Dependence 1 50.28 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Preventing the activation of protein kinase G by injecting Rp-8-pCPT-cGMPS into the crush site abolished the transport.
Negative_regulation (Preventing) of Positive_regulation (activation) of protein kinase
1) Confidence 0.35 Published 2006 Journal Neuroscience Section Abstract Doc Link 16730916 Disease Relevance 0.93 Pain Relevance 0.47
Therefore, we examined whether the inhibition of the gluconeogenic response in the liver is due to an interference with the activation of protein kinase in the following situations: (1) adrenalectomy, (2) Na+-free perfusate, (3) administration of local anesthetic.
Spec (whether) Negative_regulation (interference) of Positive_regulation (activation) of protein kinase in liver associated with local anesthetic
2) Confidence 0.26 Published 1976 Journal Biochim. Biophys. Acta Section Abstract Doc Link 179578 Disease Relevance 0 Pain Relevance 0.10
We found no significant inhibition of activation of protein kinase in the above experimental conditions.
Negative_regulation (inhibition) of Positive_regulation (activation) of protein kinase
3) Confidence 0.26 Published 1976 Journal Biochim. Biophys. Acta Section Abstract Doc Link 179578 Disease Relevance 0 Pain Relevance 0.16
Protein kinase Cbeta antisense oligodeoxynucleotide had no significant effect on the membrane-associated activities of protein kinase Calpha and protein kinase Cgamma, but decreased the activities of both protein kinase CbetaI and protein kinase CbetaII and the expression of protein kinase Cbeta isozyme in the spinal cord.
Negative_regulation (decreased) of Positive_regulation (activities) of protein kinase in spinal cord associated with spinal cord
4) Confidence 0.16 Published 2006 Journal Neuroscience Section Abstract Doc Link 16360284 Disease Relevance 0.45 Pain Relevance 0.66
Protein kinase Cbeta antisense oligodeoxynucleotide had no significant effect on the membrane-associated activities of protein kinase Calpha and protein kinase Cgamma, but decreased the activities of both protein kinase CbetaI and protein kinase CbetaII and the expression of protein kinase Cbeta isozyme in the spinal cord.
Negative_regulation (decreased) of Positive_regulation (activities) of protein kinase in spinal cord associated with spinal cord
5) Confidence 0.16 Published 2006 Journal Neuroscience Section Abstract Doc Link 16360284 Disease Relevance 0.45 Pain Relevance 0.66
These results suggest that NMDA receptor antagonists inhibit the increase in protein kinase activity produced by chronic morphine treatment, thus suppressing the naloxone-induced rise in norepinephrine release.
Negative_regulation (inhibit) of Positive_regulation (increase) of protein kinase associated with nmda receptor antagonist, narcan and morphine
6) Confidence 0.08 Published 1997 Journal J Toxicol Sci Section Abstract Doc Link 9076657 Disease Relevance 0.05 Pain Relevance 1.32
The inhibition of quantal GABA release can be reduced by an activator of protein kinase C.
Negative_regulation (reduced) of Positive_regulation (activator) of protein kinase associated with kinase c and gaba
7) Confidence 0.02 Published 1997 Journal J. Neurosci. Section Abstract Doc Link 8994057 Disease Relevance 0 Pain Relevance 0.77

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