INT123130

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Context Info
Confidence 0.49
First Reported 2003
Last Reported 2011
Negated 0
Speculated 1
Reported most in Body
Documents 22
Total Number 23
Disease Relevance 11.77
Pain Relevance 1.83

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (AKT1) nucleoplasm (AKT1) transport (AKT1)
small molecule metabolic process (AKT1) enzyme binding (AKT1) carbohydrate metabolic process (AKT1)
Anatomy Link Frequency
OC 316 4
plasma 2
AsPC-1 2
keratinocytes 2
stem cell 2
AKT1 (Homo sapiens)
Pain Link Frequency Relevance Heat
cINOD 19 95.60 Very High Very High Very High
chemokine 297 91.44 High High
diclofenac 6 87.60 High High
alcohol 96 84.12 Quite High
withdrawal 3 79.12 Quite High
addiction 5 76.16 Quite High
cytokine 30 74.40 Quite High
Inflammation 48 70.92 Quite High
aspirin 2 64.08 Quite High
acular 1 62.40 Quite High
Disease Link Frequency Relevance Heat
Apoptosis 347 100.00 Very High Very High Very High
Hypoxia 38 100.00 Very High Very High Very High
Parkinson's Disease 2 100.00 Very High Very High Very High
Endometrial Cancer 69 98.92 Very High Very High Very High
Cancer 860 98.84 Very High Very High Very High
Toxicity 20 98.64 Very High Very High Very High
Glioblastoma 16 97.76 Very High Very High Very High
Ovarian Cancer 257 96.98 Very High Very High Very High
Cv Unclassified Under Development 13 96.20 Very High Very High Very High
Alcohol Addiction 24 96.00 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Cyclo-oxygenase-2-mediated synthesis of prostaglandin E(2) (PGE(2)) leads to activation of mitogen-activated protein kinase (MAPK), as well as phosphatidylinositol 3-kinase (PI3K)/Akt pathways.
Positive_regulation (leads) of Positive_regulation (activation) of Akt
1) Confidence 0.49 Published 2007 Journal Br. J. Dermatol. Section Abstract Doc Link 17488403 Disease Relevance 1.10 Pain Relevance 0.77
MMP-2 promoter and enzyme activity were up-regulated in Akt kinase activity dependent manner.
Positive_regulation (dependent) of Positive_regulation (up-regulated) of Akt kinase
2) Confidence 0.46 Published 2005 Journal J. Cell. Biochem. Section Abstract Doc Link 15546138 Disease Relevance 0.65 Pain Relevance 0.20
Aberrations leading to increased activation of the PI3K/AKT pathway are common in human cancers and are reviewed in [31].
Positive_regulation (leading) of Positive_regulation (activation) of AKT associated with cancer
3) Confidence 0.45 Published 2010 Journal Genome Biol Section Body Doc Link PMC2945784 Disease Relevance 0.73 Pain Relevance 0
EGFR phosphorilation results in the activation of multiple pathways including PI3K- AKT.
Positive_regulation (results) of Positive_regulation (activation) of AKT
4) Confidence 0.45 Published 2007 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2376084 Disease Relevance 0.55 Pain Relevance 0
Aberrations leading to increased activation of the PI3K/AKT pathway are common in human cancers and are reviewed in [31].
Positive_regulation (increased) of Positive_regulation (activation) of AKT associated with cancer
5) Confidence 0.45 Published 2010 Journal Genome Biol Section Body Doc Link PMC2945784 Disease Relevance 0.73 Pain Relevance 0
These include (i) increase of cell proliferation and survival and perturbation of differentiation, dependent on the activation of the phosphatidylinositol 3-kinase-AKT and the ras/mitogen-activated protein kinase pathways [29, 30], (ii) increased angiogenesis, as a consequence of the ability of HER-2 to modulate the equilibrium between proangiogenic (VEGF, IL-8, angiopoietin-2) and antiangiogenic factors [31].

4.

Positive_regulation (dependent) of Positive_regulation (activation) of AKT
6) Confidence 0.45 Published 2010 Journal Journal of Nucleic Acids Section Body Doc Link PMC2911612 Disease Relevance 0.21 Pain Relevance 0
The phosphorylation of a conserved threonine residue (Thr308 in Akt1, Thr309 in Akt2 and Thr305 in Akt3), upon growth factor stimulation, is required for Akt activation, while the phosphorylation of a serine residue (Ser473 in Akt1, Ser474 in Akt2 and Ser474 in Akt3) is only required for maximal Akt activity [21,24-26].
Positive_regulation (required) of Positive_regulation (activation) of Akt
7) Confidence 0.43 Published 2006 Journal Mol Cancer Section Body Doc Link PMC1762018 Disease Relevance 0.46 Pain Relevance 0.04
In the presence of a mutated-PTEN protein, activation of Akt generally occurs constitutively.
Positive_regulation (occurs) of Positive_regulation (activation) of Akt
8) Confidence 0.40 Published 2004 Journal Mol Cancer Section Body Doc Link PMC394342 Disease Relevance 0.23 Pain Relevance 0.04
We have demonstrated previously that Akt is constitutively phosphorylated/activated in two mutated-PTEN human endometrial cancer cell lines that have been used in the present study (RL 95-2 and Ishikawa) [32,42].
Positive_regulation (phosphorylated) of Positive_regulation (activated) of Akt associated with endometrial cancer
9) Confidence 0.40 Published 2004 Journal Mol Cancer Section Body Doc Link PMC394342 Disease Relevance 0.29 Pain Relevance 0.04
Various PI 3-kinase inhibitors such as Wortmannin, LY294002 and dominant-negative Akt expression vector were used to fully prove the involvement of PI 3-K/Akt pathway in the regulation of NF-?
Positive_regulation (negative) of Positive_regulation (vector) of Akt
10) Confidence 0.37 Published 2004 Journal Mol Cancer Section Body Doc Link PMC394342 Disease Relevance 0.21 Pain Relevance 0
MNTX-induced Src inactivation results in inhibition of PI3 kinase and mTOR signaling required for Akt activation (serine/threonine phosphorylation).
Positive_regulation (required) of Positive_regulation (activation) of Akt
11) Confidence 0.33 Published 2010 Journal J Angiogenes Res Section Body Doc Link PMC2831839 Disease Relevance 0 Pain Relevance 0.03
Lovastatin and/or celecoxib also inhibited caveolin-1-dependent cell survival signals mediated through Akt activation as well as its down-stream effectors such as phosphorylated ERK and STAT3 in HCT-116 cells.
Positive_regulation (mediated) of Positive_regulation (activation) of Akt
12) Confidence 0.27 Published 2009 Journal Int. J. Oncol. Section Abstract Doc Link 19787257 Disease Relevance 0.36 Pain Relevance 0.07
Upregulation or downregulation of GEFs would also lead to an increased activity of RAC.
Positive_regulation (increased) of Positive_regulation (activity) of RAC
13) Confidence 0.24 Published 2008 Journal Eplasty Section Body Doc Link PMC2311454 Disease Relevance 0.15 Pain Relevance 0
Active PI3K generates the phosphorylated lipid phosphatidylinositol-3,4,5-triphosphate (PtdIns(3,4,5)P3), leading to the recruitment and activation of other kinases such as Akt (protein kinase B) to the plasma membrane.
Positive_regulation (leading) of Positive_regulation (activation) of Akt in plasma
14) Confidence 0.23 Published 2006 Journal BMC Cancer Section Body Doc Link PMC1601962 Disease Relevance 1.29 Pain Relevance 0
In Wnt signaling pathways, Akt phosphorylation/activation stimulates GSK3?
Positive_regulation (stimulates) of Positive_regulation (activation) of Akt
15) Confidence 0.21 Published 2010 Journal J Exp Clin Cancer Res Section Body Doc Link PMC3020166 Disease Relevance 0.08 Pain Relevance 0
Our data further revealed that enhanced activation of Akt and AMPK, and subsequently, inhibition of Foxo3, apoptosis, and mitochondrial dysfunction may play a pivotal role in ALDH2 overexpression-induced cardioprotection against ethanol toxicity [130].
Positive_regulation (induced) of Positive_regulation (activation) of Akt associated with parkinson's disease, toxicity and apoptosis
16) Confidence 0.21 Published 2010 Journal International Journal of Environmental Research and Public Health Section Body Doc Link PMC2872347 Disease Relevance 1.39 Pain Relevance 0.39
The up-regulation of these genes together with the down-regulation of PTEN led to an increase of Akt1 activity in keratinocytes and suppressed apoptosis induced by growth factors deprivation in cell culture.



Positive_regulation (led) of Positive_regulation (increase) of Akt1 in keratinocytes associated with apoptosis
17) Confidence 0.20 Published 2003 Journal Comp Hepatol Section Body Doc Link PMC151270 Disease Relevance 0.61 Pain Relevance 0
We found that Ocimum gratissimum extract helps to prevent cell apoptosis by affecting the mitochondrial pathway in 2 places and that it is able to inhibit the formation of tBid as well as stimulate the activation of Akt, which inhibits the release of CytC through the stimulation of Bcl-2 expression.
Positive_regulation (stimulate) of Positive_regulation (activation) of Akt associated with apoptosis
18) Confidence 0.15 Published 2011 Journal Evidence-based Complementary and Alternative Medicine : eCAM Section Body Doc Link PMC2952314 Disease Relevance 0.55 Pain Relevance 0
To determine whether LN-induced Akt activation in AsPC-1 cells was dependent on FAK, pool cells transfected with FAK RNAi2, pcDNA3.1-FRNK or their respective vector control were obtained.
Spec (whether) Positive_regulation (induced) of Spec (whether) Positive_regulation (activation) of Akt in AsPC-1
19) Confidence 0.15 Published 2009 Journal Mol Cancer Section Body Doc Link PMC2806309 Disease Relevance 0.21 Pain Relevance 0
was induced and their siRNA transfection resulted in attenuation of hypoxic/DHP-d activated stem cell growth and related signal protein activation, including MAPK, JAK/STAT, and AKT (Figure 3E).
Positive_regulation (resulted) of Positive_regulation (activation) of AKT in stem cell associated with hypoxia
20) Confidence 0.15 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2817727 Disease Relevance 0.56 Pain Relevance 0

General Comments

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