INT123139

Context Info Confidence 0.37 First Reported 2005 Last Reported 2008 Negated 0 Speculated 0 Reported most in Abstract Documents 7 Total Number 7 Disease Relevance 1.98 Pain Relevance 2.84

peptidase activity (Mmp3) extracellular space (Mmp3) extracellular region (Mmp3) proteinaceous extracellular matrix (Mmp3) nucleus (Mmp3) protein complex (Mmp3)

Anatomy Link Frequency cleavage 1 Mmp3 (Rattus norvegicus)

Pain Link Frequency Relevance Heat metalloproteinase 34 100.00 spinal inflammation 16 100.00 Migraine 11 98.88 headache 1 83.56 endometriosis 2 50.00 Dismenorea 2 50.00 nMDA receptor 42 5.00 Spinal cord 17 5.00 Glutamate receptor 2 5.00 Pain 1 5.00

Disease Link Frequency Relevance Heat Low Back Pain 16 100.00 Headache 11 98.88 Primary Headache Disorders 1 83.92 Dysmenorrhea 2 50.00 Endometriosis (extended) 2 50.00 Death 3 5.00 Adhesions 3 5.00 Apoptosis 2 5.00 Immunization 1 5.00 Pain 1 5.00

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Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

OBJECTIVE: To study the linkage and association of ankylosing spondylitis (AS) with genotypes for matrix metalloproteinase 3 (MMP3), a gene located at chromosome 11q22.3 and lying within the 101-124 cM region observed in a recent genome-wide scan as a region associated with AS susceptibility.

matrix metalloproteinase 3 Binding (association) of associated with spinal inflammation and metalloproteinase

1) Confidence 0.37 Published 2005 Journal Rheumatology (Oxford) Section Abstract Doc Link 15546966 Disease Relevance 0.37 Pain Relevance 0.46

Lack of association of matrix metalloproteinase 3 (MMP3) genotypes with ankylosing spondylitis susceptibility and severity.

matrix metalloproteinase 3 Binding (association) of associated with spinal inflammation and metalloproteinase

2) Confidence 0.37 Published 2005 Journal Rheumatology (Oxford) Section Title Doc Link 15546966 Disease Relevance 0.29 Pain Relevance 0.47

OBJECTIVE: To study the linkage and association of ankylosing spondylitis (AS) with genotypes for matrix metalloproteinase 3 (MMP3), a gene located at chromosome 11q22.3 and lying within the 101-124 cM region observed in a recent genome-wide scan as a region associated with AS susceptibility.

MMP3 Binding (association) of associated with spinal inflammation and metalloproteinase

3) Confidence 0.37 Published 2005 Journal Rheumatology (Oxford) Section Abstract Doc Link 15546966 Disease Relevance 0.37 Pain Relevance 0.46

Lack of association of matrix metalloproteinase 3 (MMP3) genotypes with ankylosing spondylitis susceptibility and severity.

MMP3 Binding (association) of associated with spinal inflammation and metalloproteinase

4) Confidence 0.37 Published 2005 Journal Rheumatology (Oxford) Section Title Doc Link 15546966 Disease Relevance 0.29 Pain Relevance 0.47

of the NR1 subunit may by important for sequence-specific cleavage by MMP-3.

MMP-3 Binding (cleavage) of in cleavage

5) Confidence 0.27 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2443283 Disease Relevance 0 Pain Relevance 0

CONCLUSION: Individuals with the MMP-1 2G allelotype have significantly increased risk of developing EM and adenomyosis; MMP-3 promoter SNP is not associated with susceptibility to EM and adenomyosis, 2G/6A haplotype could be used as a stratified marker for EM.

MMP-3 promoter SNP Binding (associated) of

6) Confidence 0.16 Published 2005 Journal Zhonghua Fu Chan Ke Za Zhi Section Body Doc Link 16202315 Disease Relevance 0 Pain Relevance 0

This is the first study to evaluate the association between MMP-3 and ACE polymorphisms, and migraine.

MMP-3 Binding (association) of associated with migraine and metalloproteinase

7) Confidence 0.13 Published 2007 Journal Cephalalgia Section Abstract Doc Link 17381556 Disease Relevance 0.66 Pain Relevance 0.98

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