INT12314

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Context Info
Confidence 0.56
First Reported 1992
Last Reported 2010
Negated 1
Speculated 1
Reported most in Body
Documents 16
Total Number 28
Disease Relevance 14.82
Pain Relevance 6.72

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endoplasmic reticulum (Nr3c2) nucleus (Nr3c2) cytoplasm (Nr3c2)
Anatomy Link Frequency
hippocampus 3
neuronal 1
plasma 1
nerve cells 1
5-HT neurons 1
Nr3c2 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
antagonist 21 100.00 Very High Very High Very High
Morphine 6 99.68 Very High Very High Very High
Calcium channel 7 99.38 Very High Very High Very High
excitatory amino acid 8 99.22 Very High Very High Very High
Hippocampus 399 99.08 Very High Very High Very High
conotoxin 1 99.06 Very High Very High Very High
fluoxetine 8 98.64 Very High Very High Very High
corticosteroid 119 98.52 Very High Very High Very High
Pain 8 96.40 Very High Very High Very High
antidepressant 17 96.36 Very High Very High Very High
Disease Link Frequency Relevance Heat
Stress 752 99.88 Very High Very High Very High
Post-traumatic Stress Disorder 351 99.84 Very High Very High Very High
Anxiety Disorder 130 99.32 Very High Very High Very High
Congenital Anomalies 13 98.72 Very High Very High Very High
Death 39 98.00 Very High Very High Very High
Cognitive Disorder 29 97.00 Very High Very High Very High
Nociception 5 96.76 Very High Very High Very High
Pain 4 96.40 Very High Very High Very High
Vasculitis 1 92.60 High High
Apoptosis 26 92.40 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Blockade of MR and GR produced anxiety and startle [13] and MR antagonism induced enhanced fear [14].
Negative_regulation (Blockade) of MR associated with anxiety disorder
1) Confidence 0.56 Published 2008 Journal Acta Histochemica et Cytochemica Section Body Doc Link PMC2532603 Disease Relevance 1.10 Pain Relevance 0.18
A decrease of hippocampal MR in PTSD could be responsible for the related clinical phenomena including increased startle-response, enhanced autonomic reactivity, hypervigilance, and increased anxiety.
Negative_regulation (decrease) of MR in autonomic associated with post-traumatic stress disorder and anxiety disorder
2) Confidence 0.49 Published 2008 Journal Acta Histochemica et Cytochemica Section Body Doc Link PMC2532603 Disease Relevance 0.98 Pain Relevance 0.23
We also found decreased neuronal numbers in the hippocampus after SPS (data not shown), which suggested that decreased MR- and GR-ir may have induced hippocampal neuronal death in the SPS animals.
Negative_regulation (decreased) of MR in neuronal associated with stress, hippocampus and death
3) Confidence 0.49 Published 2008 Journal Acta Histochemica et Cytochemica Section Body Doc Link PMC2532603 Disease Relevance 0.67 Pain Relevance 0.30
Activation of MR 5-HT neurons desynchronizes the hippocampal EEG, whereas inhibition of MR 5-HT activity produces hippocampal theta rhythm.
Negative_regulation (inhibition) of MR in 5-HT neurons
4) Confidence 0.43 Published 1995 Journal Psychopharmacology (Berl.) Section Abstract Doc Link 8524970 Disease Relevance 0 Pain Relevance 0.17
The present findings indicate EAA afferents to the MR normally exert an excitatory influence on the MR in its desynchronization of the hippocampal EEG, whereas the removal of EAA inputs to MR produces the opposite: a reduction of MR activity and hence the elicitation of theta.
Negative_regulation (reduction) of MR associated with excitatory amino acid
5) Confidence 0.36 Published 1994 Journal Brain Res. Section Abstract Doc Link 7982102 Disease Relevance 0 Pain Relevance 0.55
Figure 3 showed a significant down-regulation of hippocampal MR and GR protein in SPS rats in comparison with control rats (p<0.05).


Negative_regulation (down-regulation) of MR associated with stress
6) Confidence 0.36 Published 2008 Journal Acta Histochemica et Cytochemica Section Body Doc Link PMC2532603 Disease Relevance 0.81 Pain Relevance 0.20
Liberzon et al. examined decreased hippocampal MR mRNA in the same animal model [15].
Spec (examined) Negative_regulation (decreased) of MR
7) Confidence 0.36 Published 2008 Journal Acta Histochemica et Cytochemica Section Body Doc Link PMC2532603 Disease Relevance 0.75 Pain Relevance 0.24
In the SPS rat, decreased MR-ir (Fig. 1B) or GR-ir (Fig. 1D) was observed in the CA1 region.
Negative_regulation (decreased) of MR associated with stress
8) Confidence 0.36 Published 2008 Journal Acta Histochemica et Cytochemica Section Body Doc Link PMC2532603 Disease Relevance 0.48 Pain Relevance 0.07
The third is down-regulation of MR and up-regulation of GR [15].
Negative_regulation (regulation) of MR
9) Confidence 0.36 Published 2008 Journal Acta Histochemica et Cytochemica Section Body Doc Link PMC2532603 Disease Relevance 0.53 Pain Relevance 0.07
Immunohistochemistry revealed decreased MR- and GR-immunoreactivity (ir) in the CA1 of hippocampus in SPS animals.
Negative_regulation (decreased) of MR in hippocampus associated with stress and hippocampus
10) Confidence 0.36 Published 2008 Journal Acta Histochemica et Cytochemica Section Abstract Doc Link PMC2532603 Disease Relevance 1.41 Pain Relevance 0.13
The second is down-regulation of MR and unaltered GR [23].
Negative_regulation (regulation) of MR
11) Confidence 0.36 Published 2008 Journal Acta Histochemica et Cytochemica Section Body Doc Link PMC2532603 Disease Relevance 0.56 Pain Relevance 0.07
The decrease in MR suggests that lower MR does not alter the increasing sensitivity to negative feedback, or alternatively, that MR plays a less prominent role in the feedback regulation [15].
Negative_regulation (decrease) of MR
12) Confidence 0.36 Published 2008 Journal Acta Histochemica et Cytochemica Section Body Doc Link PMC2532603 Disease Relevance 0.81 Pain Relevance 0.24
Degeneration and associated loss of synaptic function could be prevented by treatment with MR ligands [29].
Negative_regulation (prevented) of MR
13) Confidence 0.36 Published 2008 Journal Acta Histochemica et Cytochemica Section Body Doc Link PMC2532603 Disease Relevance 1.20 Pain Relevance 0.19
Western blotting showed that SPS induced significantly decreased MR- and GR-protein in the whole hippocampus, although the degree of decreased expression of both receptors was different.
Negative_regulation (decreased) of MR in hippocampus associated with stress and hippocampus
14) Confidence 0.36 Published 2008 Journal Acta Histochemica et Cytochemica Section Abstract Doc Link PMC2532603 Disease Relevance 1.35 Pain Relevance 0.13
Abnormalities in negative feedback are found in PTSD, suggesting that GR and MR might be involved in the pathophysiology of these disorders.
Negative_regulation (involved) of MR associated with post-traumatic stress disorder and congenital anomalies
15) Confidence 0.36 Published 2008 Journal Acta Histochemica et Cytochemica Section Abstract Doc Link PMC2532603 Disease Relevance 1.31 Pain Relevance 0.12
Repeated morphine administration down-regulates glucocorticoid, but not mineralocorticoid, receptors in the rat hippocampus.
Negative_regulation (down-regulates) of mineralocorticoid in hippocampus associated with hippocampus and morphine
16) Confidence 0.35 Published 1995 Journal Psychoneuroendocrinology Section Title Doc Link 7838904 Disease Relevance 0 Pain Relevance 0.63
The L-, N-, and T-type triple calcium channel blocker benidipine acts as an antagonist of mineralocorticoid receptor, a member of nuclear receptor family.
Negative_regulation (antagonist) of mineralocorticoid receptor associated with antagonist and calcium channel
17) Confidence 0.33 Published 2010 Journal Eur. J. Pharmacol. Section Title Doc Link 20307534 Disease Relevance 0.36 Pain Relevance 0.48
Furthermore, reduced MR during stress is not a direct consequence of increased CORT.
Negative_regulation (reduced) of MR associated with stress
18) Confidence 0.31 Published 1992 Journal Physiol. Behav. Section Abstract Doc Link 1641416 Disease Relevance 0.30 Pain Relevance 0.17
PCA produced an 87% decrease in hippocampal 5-HT and 5-HIAA levels, but did not alter hippocampal GR or MR levels.
Negative_regulation (hippocampal) of MR
19) Confidence 0.26 Published 1995 Journal Brain Res. Section Abstract Doc Link 7583200 Disease Relevance 0 Pain Relevance 0.26
Compared to nonstressed lactators, dams exposed to sound demonstrated no suppression in MR, but a significant increase in plasma CORT.
Neg (no) Negative_regulation (suppression) of MR in plasma
20) Confidence 0.23 Published 1992 Journal Physiol. Behav. Section Abstract Doc Link 1641416 Disease Relevance 0.28 Pain Relevance 0.16

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