INT123142

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Context Info
Confidence 0.76
First Reported 2004
Last Reported 2010
Negated 2
Speculated 3
Reported most in Body
Documents 54
Total Number 57
Disease Relevance 36.14
Pain Relevance 10.02

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (DEFB4A)
Anatomy Link Frequency
skin 8
bowel 5
keratinocytes 3
epithelial cell 2
urine 1
DEFB4A (Homo sapiens)
Pain Link Frequency Relevance Heat
psoriasis 1469 100.00 Very High Very High Very High
cytokine 655 99.78 Very High Very High Very High
Inflammation 488 99.60 Very High Very High Very High
spastic colon 195 99.02 Very High Very High Very High
rheumatoid arthritis 290 98.46 Very High Very High Very High
chemokine 39 98.22 Very High Very High Very High
cINOD 38 97.64 Very High Very High Very High
pulpitis 2 95.52 Very High Very High Very High
Inflammatory response 12 90.68 High High
Arthritis 30 62.04 Quite High
Disease Link Frequency Relevance Heat
Psoriasis 2028 100.00 Very High Very High Very High
Cancer 30 100.00 Very High Very High Very High
Necrosis 23 99.96 Very High Very High Very High
Disease 1123 99.74 Very High Very High Very High
Blister 9 99.64 Very High Very High Very High
INFLAMMATION 505 99.60 Very High Very High Very High
Eczema 552 99.38 Very High Very High Very High
Burns 87 99.32 Very High Very High Very High
Irritable Bowel Syndrome /

Irritable Bowel Syndrome Super

180 99.12 Very High Very High Very High
Infection 124 99.12 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
-defensin 2 (DEFB4) expression.
Gene_expression (expression) of DEFB4
1) Confidence 0.76 Published 2006 Journal BMC Infect Dis Section Body Doc Link PMC1368979 Disease Relevance 0.57 Pain Relevance 0.16
METHODS: Immunohistochemistry was conducted on the biopsy samples of colonic mucosa from 30 UC patients, 20 IBS-D patients, and 10 normal persons to measure the expression of HBD-2 and TNF-alpha.
Gene_expression (expression) of HBD-2
2) Confidence 0.75 Published 2008 Journal Zhonghua Yi Xue Za Zhi Section Body Doc Link 18756966 Disease Relevance 0.17 Pain Relevance 0
RESULTS: The expression levels of HBD-2 and TNF-alpha in the colonic mucosa of UC were both significantly higher than those in the colonic mucosa of IBS-D (z = -4.856, z = -3. 987, all P < 0.01) and in the normal colonic mucosa (z = -3.611, z = -3. 248, all P < 0.01).
Gene_expression (expression) of HBD-2
3) Confidence 0.75 Published 2008 Journal Zhonghua Yi Xue Za Zhi Section Body Doc Link 18756966 Disease Relevance 0.17 Pain Relevance 0
CONCLUSION: The expressions of HBD-2 and TNF-at are significantly increased in UC, but are not correlated with IBS-D and the severity of clinical symptoms of UC patients.


Gene_expression (expressions) of HBD-2
4) Confidence 0.75 Published 2008 Journal Zhonghua Yi Xue Za Zhi Section Body Doc Link 18756966 Disease Relevance 0.12 Pain Relevance 0
But no significant differences were found between the colonic mucosa of IBS-D and the normal colonic mucosa in the intensity of the expressions of HBD-2 and TNF-alpha (z = -0.373, z = -0.032, all P > 0.05).
Gene_expression (expressions) of HBD-2
5) Confidence 0.75 Published 2008 Journal Zhonghua Yi Xue Za Zhi Section Body Doc Link 18756966 Disease Relevance 0.14 Pain Relevance 0
There were no significant differences in the intensity of the expressions of HBD-2 and TNF-alpha in colonic mucosa of among the mild, moderate, and severe UC (chi2 = 1.190, P > 0.05, chi2 = 1.672, P > 0. 05).
Gene_expression (expressions) of HBD-2
6) Confidence 0.75 Published 2008 Journal Zhonghua Yi Xue Za Zhi Section Body Doc Link 18756966 Disease Relevance 0.13 Pain Relevance 0
OBJECTIVE: To detect the expression of human beta-defensin 2 (HBD-2) and tumor necrosis factor-alpha (TNF-alpha) in the colonic mucosae of ulcerative colitis (UC) patients and diarrhea-predominant irritable bowel syndrome (IBS-D) patients and to evaluate the roles of HBD-2 and TNF-alpha in the pathogenesis and the relationship between them.
Gene_expression (expression) of HBD-2 in bowel associated with inflammatory bowel disease, necrosis, diarrhoea, cancer and spastic colon
7) Confidence 0.75 Published 2008 Journal Zhonghua Yi Xue Za Zhi Section Abstract Doc Link 18756966 Disease Relevance 0.86 Pain Relevance 0.17
We analyzed the expression of hBD-2 at the protein level by immunohistochemistry.
Spec (analyzed) Gene_expression (expression) of hBD-2
8) Confidence 0.71 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2649503 Disease Relevance 0.33 Pain Relevance 0
On the basis of the limited expression of hBD-2 in normal human tissues, as demonstrated in figure 1, we expected low levels of protein in normal human serum.
Gene_expression (expression) of hBD-2
9) Confidence 0.71 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2649503 Disease Relevance 0.21 Pain Relevance 0
As previously reported [10], hBD-2 protein is expressed at low to undetectable levels (immunohistochemistry) in lesional atopic dermatitis, despite strong induction at the mRNA level.
Gene_expression (expressed) of hBD-2 protein associated with eczema
10) Confidence 0.71 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2649503 Disease Relevance 1.66 Pain Relevance 0.39
Of the eight beta-defensin genes located on 8p23.1, human beta-defensin-1 (hBD-1) protein, (encoded by DEFB1) and hBD-3 (encoded by DEFB103) are constitutively expressed at low levels in skin [24]. hBD-2 (encoded by DEFB4) is not expressed in normal skin but is highly expressed in psoriatic skin. hBD-4 (encoded by DEFB104) is less well characterized at the protein level but is found in skin by RT-PCR. hBD-2, hBD-3 and hBD-4 can be induced by cytokines and bacterial lipopolysaccharides in various epithelial cell types [25].
Gene_expression (expressed) of hBD-2 in skin associated with psoriasis and cytokine
11) Confidence 0.71 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2649503 Disease Relevance 0.45 Pain Relevance 0.17
We could indeed show that Th2 cytokines do not induce hBD-2 expression in cultured keratinocytes [18] and that Th2 cytokines repress the Th1 induced expression (not shown here), as was previously shown for hBD-3 [43].
Gene_expression (expression) of hBD-2 in keratinocytes associated with cytokine
12) Confidence 0.71 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2649503 Disease Relevance 1.12 Pain Relevance 0.48
Strongly increased levels were also found in the urine of psoriasis patients whereas hBD-2 could not be detected in urine of healthy controls.
Neg (not) Gene_expression (detected) of hBD-2 in urine associated with psoriasis
13) Confidence 0.71 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2649503 Disease Relevance 0.81 Pain Relevance 0.30
An additional level of regulation of hBD-2 expression is the responsiveness of cells to pro-inflammatory cytokines.
Gene_expression (expression) of hBD-2 associated with inflammation and cytokine
14) Confidence 0.71 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2649503 Disease Relevance 1.05 Pain Relevance 0.57
Although our findings indicate that uninduced hBD-2 production is subject to gene dosage effects, the high systemic serum levels in psoriasis patients are caused by disease activity itself.
Gene_expression (production) of hBD-2 associated with psoriasis and disease
15) Confidence 0.71 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2649503 Disease Relevance 0.77 Pain Relevance 0.20
-defensin 2 (DEFB4) promoter construct was transfected into HMEEC followed by treatment with NTHi lysate and IL-1?
Gene_expression (transfected) of DEFB4 associated with hemophilus infection
16) Confidence 0.66 Published 2006 Journal BMC Infect Dis Section Body Doc Link PMC1368979 Disease Relevance 0.97 Pain Relevance 0
[Expression of human beta-defensin 2 and tumor necrosis factor-A in colonic mucosae of ulcerative colitis and diarrhea-predominant irritable bowel syndrome].
Gene_expression (Expression) of beta-defensin 2 in bowel associated with inflammatory bowel disease, necrosis, diarrhoea, cancer and spastic colon
17) Confidence 0.65 Published 2008 Journal Zhonghua Yi Xue Za Zhi Section Title Doc Link 18756966 Disease Relevance 0.77 Pain Relevance 0.18
OBJECTIVE: To detect the expression of human beta-defensin 2 (HBD-2) and tumor necrosis factor-alpha (TNF-alpha) in the colonic mucosae of ulcerative colitis (UC) patients and diarrhea-predominant irritable bowel syndrome (IBS-D) patients and to evaluate the roles of HBD-2 and TNF-alpha in the pathogenesis and the relationship between them.
Gene_expression (expression) of beta-defensin 2 in bowel associated with inflammatory bowel disease, necrosis, diarrhoea, cancer and spastic colon
18) Confidence 0.65 Published 2008 Journal Zhonghua Yi Xue Za Zhi Section Abstract Doc Link 18756966 Disease Relevance 0.86 Pain Relevance 0.17
OBJECTIVE: To detect the expression of human beta-defensin 2 (HBD-2) and tumor necrosis factor-alpha (TNF-alpha) in the colonic mucosae of ulcerative colitis (UC) patients and diarrhea-predominant irritable bowel syndrome (IBS-D) patients and to evaluate the roles of HBD-2 and TNF-alpha in the pathogenesis and the relationship between them.
Gene_expression (roles) of HBD-2 in bowel associated with inflammatory bowel disease, necrosis, diarrhoea, cancer and spastic colon
19) Confidence 0.65 Published 2008 Journal Zhonghua Yi Xue Za Zhi Section Abstract Doc Link 18756966 Disease Relevance 0.86 Pain Relevance 0.17
OBJECTIVE: To detect the expression of human beta-defensin 2 (HBD-2) and tumor necrosis factor-alpha (TNF-alpha) in the colonic mucosae of ulcerative colitis (UC) patients and diarrhea-predominant irritable bowel syndrome (IBS-D) patients and to evaluate the roles of HBD-2 and TNF-alpha in the pathogenesis and the relationship between them.
Gene_expression (detect) of HBD-2 in bowel associated with inflammatory bowel disease, necrosis, diarrhoea, cancer and spastic colon
20) Confidence 0.65 Published 2008 Journal Zhonghua Yi Xue Za Zhi Section Abstract Doc Link 18756966 Disease Relevance 0.86 Pain Relevance 0.17

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