INT123143

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Context Info
Confidence 0.74
First Reported 2004
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 6
Disease Relevance 4.13
Pain Relevance 1.04

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (DEFB4A)
Anatomy Link Frequency
skin 1
FDCs 1
DEFB4A (Homo sapiens)
Pain Link Frequency Relevance Heat
psoriasis 250 98.60 Very High Very High Very High
cytokine 95 96.80 Very High Very High Very High
cINOD 7 93.92 High High
Inflammation 70 89.80 High High
Arthritis 5 79.84 Quite High
rheumatoid arthritis 50 78.88 Quite High
chemokine 5 5.00 Very Low Very Low Very Low
Crohn's disease 5 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Disease 190 99.76 Very High Very High Very High
Psoriasis 345 98.60 Very High Very High Very High
Eczema 95 96.92 Very High Very High Very High
Infection 14 95.40 Very High Very High Very High
INFLAMMATION 71 93.36 High High
Gastritis 3 91.80 High High
Peptic Ulcer 1 91.24 High High
Seronegative Spondarthritis 5 79.84 Quite High
Rheumatoid Arthritis 50 78.88 Quite High
Bacterial Infection 1 75.20 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
At the tissue level, hBD-2 secretion will be determined both by copy number and by stimulation with proinflammatory cytokines.
Localization (secretion) of hBD-2 associated with cytokine
1) Confidence 0.74 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2649503 Disease Relevance 1.28 Pain Relevance 0.40
We investigated the expression of HBD-2 and NF-kappaB by RT-PCR and immunoblotting, and the relation between the localization of HBD-2 and follicular dendritic cells (FDCs) by immunohistochemistry.
Localization (localization) of HBD-2 in FDCs
2) Confidence 0.66 Published 2004 Journal Int. J. Mol. Med. Section Abstract Doc Link 15547668 Disease Relevance 0.86 Pain Relevance 0.19
In addition, commercially available ELISA kits were used to measure hBD-2 and hBD-3 protein in serum.
Localization (measure) of hBD-2
3) Confidence 0.65 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2649503 Disease Relevance 0.32 Pain Relevance 0.04
Serum hBD-2 was found to be stable upon storage at ?
Localization (found) of hBD-2
4) Confidence 0.60 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2649503 Disease Relevance 0.12 Pain Relevance 0.03
Serum hBD-2 is a disease marker in individual psoriasis patients
Localization (Serum) of hBD-2 associated with psoriasis and disease
5) Confidence 0.60 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2649503 Disease Relevance 1.31 Pain Relevance 0.17
Using ELISA we found that these cultures, consisting of 8 mm diameter skin constructs, secreted approximately 66±19 ng hBD-2 per 24 hours into the tissue culture medium (mean and SD of four cultures).
Localization (secreted) of hBD-2 in skin
6) Confidence 0.57 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2649503 Disease Relevance 0.24 Pain Relevance 0.22

General Comments

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