INT123144

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Context Info
Confidence 0.45
First Reported 2004
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 4
Total Number 4
Disease Relevance 2.12
Pain Relevance 1.08

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (DEFB1)
Anatomy Link Frequency
dendritic cells 1
stomach 1
T-cells 1
DEFB1 (Homo sapiens)
Pain Link Frequency Relevance Heat
cytokine 39 88.44 High High
tolerance 6 79.88 Quite High
Inflammation 28 71.76 Quite High
psoriasis 100 70.48 Quite High
Glutamate 6 68.08 Quite High
Crohn's disease 2 62.88 Quite High
cINOD 4 56.80 Quite High
Arthritis 2 17.48 Low Low
rheumatoid arthritis 20 16.52 Low Low
Bile 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Bacterial Infection 1 93.36 High High
Gastritis 3 90.96 High High
Infection 8 88.24 High High
Psoriasis 138 80.36 Quite High
Stress 10 79.48 Quite High
INFLAMMATION 29 71.76 Quite High
Eczema 38 71.60 Quite High
Disease 76 69.84 Quite High
Celiac Disease 2 60.88 Quite High
Peptic Ulcer 1 60.80 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Several studies have demonstrated the biological activities of human and mouse beta-defensins, such as antimicrobial activity [9], chemotaxis of T-cells and dendritic cells [44], and activation of TLR4 [45].
Positive_regulation (activation) of beta-defensin in dendritic cells
1) Confidence 0.45 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2649503 Disease Relevance 0.67 Pain Relevance 0.42
Human beta-defensins (HBDs) recognized in the stomach include HBD1, which is the constitutional human beta-defensin (HBD), and HBD-2 and HBD-4, which are inducible HBDs.
Positive_regulation (inducible) of HBD1 in stomach
2) Confidence 0.16 Published 2004 Journal Int. J. Mol. Med. Section Abstract Doc Link 15547668 Disease Relevance 0.63 Pain Relevance 0.11
Several studies have demonstrated the biological activities of human and mouse beta-defensins, such as antimicrobial activity [9], chemotaxis of T-cells and dendritic cells [44], and activation of TLR4 [45].
Positive_regulation (activation) of beta-defensin in T-cells
3) Confidence 0.15 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2649503 Disease Relevance 0.67 Pain Relevance 0.42
To study changes in gene expression occurring in B. dentium Bd1 in response to acidic conditions, cultures were exposed to acidic conditions simulating those occurring in active carious lesions (pH 4).
Positive_regulation (occurring) of Bd1
4) Confidence 0.13 Published 2009 Journal PLoS Genetics Section Body Doc Link PMC2788695 Disease Relevance 0.15 Pain Relevance 0.13

General Comments

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