INT12315

Context Info Confidence 0.75 First Reported 1985 Last Reported 2010 Negated 0 Speculated 1 Reported most in Body Documents 37 Total Number 38 Disease Relevance 19.28 Pain Relevance 11.97

endoplasmic reticulum (Nr3c2) nucleus (Nr3c2) cytoplasm (Nr3c2)

Anatomy Link Frequency hippocampus 8 dentate gyrus 1 respiratory 1 urine 1 Nr3c2 (Rattus norvegicus)

Pain Link Frequency Relevance Heat bDMF 114 100.00 imagery 56 100.00 butorphanol 2 100.00 antidepressant 55 99.80 Hippocampus 590 99.74 Neurotransmitter 10 99.48 corticosteroid 179 99.16 Endep 13 99.10 5HT 24 99.08 agonist 7 99.08

Disease Link Frequency Relevance Heat Stress 1088 100.00 Anxiety Disorder 190 100.00 Post-traumatic Stress Disorder 513 99.84 Anorexia 1 99.30 Aging 2 99.28 Cognitive Disorder 43 98.36 Traumatic Stress Disorders 38 96.92 Death 58 96.76 Apoptosis 98 96.52 Syndrome 38 95.60

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Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Expressions of Hippocampal Mineralocorticoid Receptor (MR) and Glucocorticoid Receptor (GR) in the Single-Prolonged Stress-Rats Post-traumatic stress disorder (PTSD) is a stress-related mental disorder caused by traumatic experience.

Gene_expression (Expressions) of MR associated with mental disorders, stress, post-traumatic stress disorder and traumatic stress disorders

1) Confidence 0.75 Published 2008 Journal Acta Histochemica et Cytochemica Section Title Doc Link PMC2532603 Disease Relevance 1.33 Pain Relevance 0.10

To examine the link between PTSD and corticosteroid receptors in the hippocampus, we studied expression of MR and GR after SPS stress using immunohistochemistry and western blotting.

Gene_expression (expression) of MR in hippocampus associated with stress, corticosteroid, post-traumatic stress disorder and hippocampus

2) Confidence 0.75 Published 2008 Journal Acta Histochemica et Cytochemica Section Body Doc Link PMC2532603 Disease Relevance 1.14 Pain Relevance 0.20

Changes of MR and GR expression in the hippocampal region between control and SPS rats are presented in Figure 3.

Gene_expression (expression) of MR associated with stress

3) Confidence 0.75 Published 2008 Journal Acta Histochemica et Cytochemica Section Body Doc Link PMC2532603 Disease Relevance 0.68 Pain Relevance 0.10

It is not known whether homodimers, heterodimers, or both caused the decreased expression of MR and GR.

Gene_expression (expression) of MR

4) Confidence 0.75 Published 2008 Journal Acta Histochemica et Cytochemica Section Body Doc Link PMC2532603 Disease Relevance 0.49 Pain Relevance 0.11

Interestingly, previous studies also suggest different regulation patterns in MR and GR expression with decreased MR/GR ratio in PTSD.

Gene_expression (expression) of MR associated with post-traumatic stress disorder

5) Confidence 0.75 Published 2008 Journal Acta Histochemica et Cytochemica Section Body Doc Link PMC2532603 Disease Relevance 0.42 Pain Relevance 0.10

Expressions of Hippocampal Mineralocorticoid Receptor (MR) and Glucocorticoid Receptor (GR) in the Single-Prolonged Stress-Rats Post-traumatic stress disorder (PTSD) is a stress-related mental disorder caused by traumatic experience.

Gene_expression (Expressions) of Mineralocorticoid Receptor associated with mental disorders, stress, post-traumatic stress disorder and traumatic stress disorders

6) Confidence 0.65 Published 2008 Journal Acta Histochemica et Cytochemica Section Title Doc Link PMC2532603 Disease Relevance 1.32 Pain Relevance 0.10

In the present study, we performed immunohistochemistry and western blotting to examine the changes in hippocampal MR- and GR-expression after SPS.

Gene_expression (expression) of MR associated with stress

7) Confidence 0.65 Published 2008 Journal Acta Histochemica et Cytochemica Section Abstract Doc Link PMC2532603 Disease Relevance 1.41 Pain Relevance 0.13

Antidepressants increase expression of hippocampal MR and decrease basal and stress-induced HPA activity.

Gene_expression (expression) of MR associated with stress and antidepressant

8) Confidence 0.65 Published 2008 Journal Acta Histochemica et Cytochemica Section Body Doc Link PMC2532603 Disease Relevance 1.12 Pain Relevance 0.18

Interestingly, previous studies also suggest different regulation patterns in MR and GR expression with decreased MR/GR ratio in PTSD.

Gene_expression (ratio) of MR/GR associated with post-traumatic stress disorder

9) Confidence 0.65 Published 2008 Journal Acta Histochemica et Cytochemica Section Body Doc Link PMC2532603 Disease Relevance 0.41 Pain Relevance 0.10

We have examined the MR/GR ratios in CA1 and whole hippocampus (Fig. 4).

Spec (examined) Gene_expression (ratios) of MR/GR in hippocampus associated with hippocampus

10) Confidence 0.65 Published 2008 Journal Acta Histochemica et Cytochemica Section Body Doc Link PMC2532603 Disease Relevance 0.76 Pain Relevance 0.20

Using western blotting we disclosed the presence of MR and GR in the hippocampal area.

Gene_expression (presence) of MR

11) Confidence 0.65 Published 2008 Journal Acta Histochemica et Cytochemica Section Body Doc Link PMC2532603 Disease Relevance 0.74 Pain Relevance 0.14

Immunoreactive signals for MR, GR and ?

Gene_expression (signals) of MR

12) Confidence 0.65 Published 2008 Journal Acta Histochemica et Cytochemica Section Body Doc Link PMC2532603 Disease Relevance 0.67 Pain Relevance 0.09

The MR/GR ratios

Gene_expression (ratios) of MR/GR

13) Confidence 0.65 Published 2008 Journal Acta Histochemica et Cytochemica Section Body Doc Link PMC2532603 Disease Relevance 0.76 Pain Relevance 0.19

We found altered MR/GR ratio of both CA1-subregion and all hippocampus in the SPS animals.

Gene_expression (ratio) of MR/GR in hippocampus associated with stress and hippocampus

14) Confidence 0.65 Published 2008 Journal Acta Histochemica et Cytochemica Section Body Doc Link PMC2532603 Disease Relevance 0.87 Pain Relevance 0.45

MR mRNA expression was induced in hippocampal CA1/CA2 subregions (27-37%) by all antidepressants, while moclobemide and 8-OH-DPAT significantly increased GR gene expression mainly in the CA1 region (31-44%).

Gene_expression (expression) of MR mRNA associated with antidepressant

15) Confidence 0.61 Published 2000 Journal Psychopharmacology (Berl.) Section Abstract Doc Link 10958110 Disease Relevance 0 Pain Relevance 0.32

SPS produced decrease expression of MR and GR in the hippocampus.

Gene_expression (expression) of MR in hippocampus associated with stress and hippocampus

16) Confidence 0.58 Published 2008 Journal Acta Histochemica et Cytochemica Section Body Doc Link PMC2532603 Disease Relevance 0.63 Pain Relevance 0.26

In present study, we examined the SPS induced down regulation of MR and GR protein expression and the change in MR/GR ratio in the hippocampus.

Gene_expression (expression) of MR in hippocampus associated with stress and hippocampus

17) Confidence 0.58 Published 2008 Journal Acta Histochemica et Cytochemica Section Body Doc Link PMC2532603 Disease Relevance 0.72 Pain Relevance 0.23

Blockade of MR and GR produced anxiety and startle [13] and MR antagonism induced enhanced fear [14].

Gene_expression (produced) of MR associated with anxiety disorder

18) Confidence 0.56 Published 2008 Journal Acta Histochemica et Cytochemica Section Body Doc Link PMC2532603 Disease Relevance 1.14 Pain Relevance 0.21

Selective effects on NGFI-A, MR, GR and NGFI-B hippocampal mRNA expression after chronic treatment with different subclasses of antidepressants in the rat.

Gene_expression (expression) of MR associated with antidepressant

19) Confidence 0.53 Published 2000 Journal Psychopharmacology (Berl.) Section Title Doc Link 10958110 Disease Relevance 0 Pain Relevance 0.28

The MR or GR data in the control and SPS groups were expressed as mean±standard deviation, and by unpaired samples t-test between the groups.

Gene_expression (expressed) of MR associated with stress

20) Confidence 0.51 Published 2008 Journal Acta Histochemica et Cytochemica Section Body Doc Link PMC2532603 Disease Relevance 0.24 Pain Relevance 0.08

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