INT12315

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Context Info
Confidence 0.75
First Reported 1985
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 37
Total Number 38
Disease Relevance 19.28
Pain Relevance 11.97

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endoplasmic reticulum (Nr3c2) nucleus (Nr3c2) cytoplasm (Nr3c2)
Anatomy Link Frequency
hippocampus 8
dentate gyrus 1
respiratory 1
urine 1
Nr3c2 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
bDMF 114 100.00 Very High Very High Very High
imagery 56 100.00 Very High Very High Very High
butorphanol 2 100.00 Very High Very High Very High
antidepressant 55 99.80 Very High Very High Very High
Hippocampus 590 99.74 Very High Very High Very High
Neurotransmitter 10 99.48 Very High Very High Very High
corticosteroid 179 99.16 Very High Very High Very High
Endep 13 99.10 Very High Very High Very High
5HT 24 99.08 Very High Very High Very High
agonist 7 99.08 Very High Very High Very High
Disease Link Frequency Relevance Heat
Stress 1088 100.00 Very High Very High Very High
Anxiety Disorder 190 100.00 Very High Very High Very High
Post-traumatic Stress Disorder 513 99.84 Very High Very High Very High
Anorexia 1 99.30 Very High Very High Very High
Aging 2 99.28 Very High Very High Very High
Cognitive Disorder 43 98.36 Very High Very High Very High
Traumatic Stress Disorders 38 96.92 Very High Very High Very High
Death 58 96.76 Very High Very High Very High
Apoptosis 98 96.52 Very High Very High Very High
Syndrome 38 95.60 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Expressions of Hippocampal Mineralocorticoid Receptor (MR) and Glucocorticoid Receptor (GR) in the Single-Prolonged Stress-Rats

Post-traumatic stress disorder (PTSD) is a stress-related mental disorder caused by traumatic experience.

Gene_expression (Expressions) of MR associated with mental disorders, stress, post-traumatic stress disorder and traumatic stress disorders
1) Confidence 0.75 Published 2008 Journal Acta Histochemica et Cytochemica Section Title Doc Link PMC2532603 Disease Relevance 1.33 Pain Relevance 0.10
To examine the link between PTSD and corticosteroid receptors in the hippocampus, we studied expression of MR and GR after SPS stress using immunohistochemistry and western blotting.


Gene_expression (expression) of MR in hippocampus associated with stress, corticosteroid, post-traumatic stress disorder and hippocampus
2) Confidence 0.75 Published 2008 Journal Acta Histochemica et Cytochemica Section Body Doc Link PMC2532603 Disease Relevance 1.14 Pain Relevance 0.20
Changes of MR and GR expression in the hippocampal region between control and SPS rats are presented in Figure 3.
Gene_expression (expression) of MR associated with stress
3) Confidence 0.75 Published 2008 Journal Acta Histochemica et Cytochemica Section Body Doc Link PMC2532603 Disease Relevance 0.68 Pain Relevance 0.10
It is not known whether homodimers, heterodimers, or both caused the decreased expression of MR and GR.
Gene_expression (expression) of MR
4) Confidence 0.75 Published 2008 Journal Acta Histochemica et Cytochemica Section Body Doc Link PMC2532603 Disease Relevance 0.49 Pain Relevance 0.11
Interestingly, previous studies also suggest different regulation patterns in MR and GR expression with decreased MR/GR ratio in PTSD.
Gene_expression (expression) of MR associated with post-traumatic stress disorder
5) Confidence 0.75 Published 2008 Journal Acta Histochemica et Cytochemica Section Body Doc Link PMC2532603 Disease Relevance 0.42 Pain Relevance 0.10
Expressions of Hippocampal Mineralocorticoid Receptor (MR) and Glucocorticoid Receptor (GR) in the Single-Prolonged Stress-Rats

Post-traumatic stress disorder (PTSD) is a stress-related mental disorder caused by traumatic experience.

Gene_expression (Expressions) of Mineralocorticoid Receptor associated with mental disorders, stress, post-traumatic stress disorder and traumatic stress disorders
6) Confidence 0.65 Published 2008 Journal Acta Histochemica et Cytochemica Section Title Doc Link PMC2532603 Disease Relevance 1.32 Pain Relevance 0.10
In the present study, we performed immunohistochemistry and western blotting to examine the changes in hippocampal MR- and GR-expression after SPS.
Gene_expression (expression) of MR associated with stress
7) Confidence 0.65 Published 2008 Journal Acta Histochemica et Cytochemica Section Abstract Doc Link PMC2532603 Disease Relevance 1.41 Pain Relevance 0.13
Antidepressants increase expression of hippocampal MR and decrease basal and stress-induced HPA activity.
Gene_expression (expression) of MR associated with stress and antidepressant
8) Confidence 0.65 Published 2008 Journal Acta Histochemica et Cytochemica Section Body Doc Link PMC2532603 Disease Relevance 1.12 Pain Relevance 0.18
Interestingly, previous studies also suggest different regulation patterns in MR and GR expression with decreased MR/GR ratio in PTSD.
Gene_expression (ratio) of MR/GR associated with post-traumatic stress disorder
9) Confidence 0.65 Published 2008 Journal Acta Histochemica et Cytochemica Section Body Doc Link PMC2532603 Disease Relevance 0.41 Pain Relevance 0.10
We have examined the MR/GR ratios in CA1 and whole hippocampus (Fig. 4).
Spec (examined) Gene_expression (ratios) of MR/GR in hippocampus associated with hippocampus
10) Confidence 0.65 Published 2008 Journal Acta Histochemica et Cytochemica Section Body Doc Link PMC2532603 Disease Relevance 0.76 Pain Relevance 0.20
Using western blotting we disclosed the presence of MR and GR in the hippocampal area.
Gene_expression (presence) of MR
11) Confidence 0.65 Published 2008 Journal Acta Histochemica et Cytochemica Section Body Doc Link PMC2532603 Disease Relevance 0.74 Pain Relevance 0.14
Immunoreactive signals for MR, GR and ?
Gene_expression (signals) of MR
12) Confidence 0.65 Published 2008 Journal Acta Histochemica et Cytochemica Section Body Doc Link PMC2532603 Disease Relevance 0.67 Pain Relevance 0.09
The MR/GR ratios
Gene_expression (ratios) of MR/GR
13) Confidence 0.65 Published 2008 Journal Acta Histochemica et Cytochemica Section Body Doc Link PMC2532603 Disease Relevance 0.76 Pain Relevance 0.19
We found altered MR/GR ratio of both CA1-subregion and all hippocampus in the SPS animals.
Gene_expression (ratio) of MR/GR in hippocampus associated with stress and hippocampus
14) Confidence 0.65 Published 2008 Journal Acta Histochemica et Cytochemica Section Body Doc Link PMC2532603 Disease Relevance 0.87 Pain Relevance 0.45
MR mRNA expression was induced in hippocampal CA1/CA2 subregions (27-37%) by all antidepressants, while moclobemide and 8-OH-DPAT significantly increased GR gene expression mainly in the CA1 region (31-44%).
Gene_expression (expression) of MR mRNA associated with antidepressant
15) Confidence 0.61 Published 2000 Journal Psychopharmacology (Berl.) Section Abstract Doc Link 10958110 Disease Relevance 0 Pain Relevance 0.32
SPS produced decrease expression of MR and GR in the hippocampus.
Gene_expression (expression) of MR in hippocampus associated with stress and hippocampus
16) Confidence 0.58 Published 2008 Journal Acta Histochemica et Cytochemica Section Body Doc Link PMC2532603 Disease Relevance 0.63 Pain Relevance 0.26
In present study, we examined the SPS induced down regulation of MR and GR protein expression and the change in MR/GR ratio in the hippocampus.
Gene_expression (expression) of MR in hippocampus associated with stress and hippocampus
17) Confidence 0.58 Published 2008 Journal Acta Histochemica et Cytochemica Section Body Doc Link PMC2532603 Disease Relevance 0.72 Pain Relevance 0.23
Blockade of MR and GR produced anxiety and startle [13] and MR antagonism induced enhanced fear [14].
Gene_expression (produced) of MR associated with anxiety disorder
18) Confidence 0.56 Published 2008 Journal Acta Histochemica et Cytochemica Section Body Doc Link PMC2532603 Disease Relevance 1.14 Pain Relevance 0.21
Selective effects on NGFI-A, MR, GR and NGFI-B hippocampal mRNA expression after chronic treatment with different subclasses of antidepressants in the rat.
Gene_expression (expression) of MR associated with antidepressant
19) Confidence 0.53 Published 2000 Journal Psychopharmacology (Berl.) Section Title Doc Link 10958110 Disease Relevance 0 Pain Relevance 0.28
The MR or GR data in the control and SPS groups were expressed as mean±standard deviation, and by unpaired samples t-test between the groups.
Gene_expression (expressed) of MR associated with stress
20) Confidence 0.51 Published 2008 Journal Acta Histochemica et Cytochemica Section Body Doc Link PMC2532603 Disease Relevance 0.24 Pain Relevance 0.08

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