INT12316

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Context Info
Confidence 0.38
First Reported 1992
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 10
Total Number 11
Disease Relevance 5.89
Pain Relevance 6.08

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (Cort)
Anatomy Link Frequency
plasma 4
Blood 1
NAcs 1
adipocyte 1
Cort (Rattus norvegicus)
Pain Link Frequency Relevance Heat
dexamethasone 94 100.00 Very High Very High Very High
Morphine 24 99.68 Very High Very High Very High
Calcitonin gene-related peptide 64 99.56 Very High Very High Very High
Dopamine 8 99.28 Very High Very High Very High
electroacupuncture 182 99.12 Very High Very High Very High
Inflammation 116 98.64 Very High Very High Very High
Hyperalgesia 30 97.96 Very High Very High Very High
spinal dorsal horn 22 95.56 Very High Very High Very High
Somatostatin 42 93.92 High High
substance P 58 93.72 High High
Disease Link Frequency Relevance Heat
Stress 77 100.00 Very High Very High Very High
Polycystic Ovary Syndrome 14 100.00 Very High Very High Very High
Nociception 53 99.78 Very High Very High Very High
Eating Disorder 8 99.66 Very High Very High Very High
Newborn Drug Withdrawal Syndrome 1 98.84 Very High Very High Very High
INFLAMMATION 136 98.64 Very High Very High Very High
Pressure And Volume Under Development 36 98.60 Very High Very High Very High
Hyperalgesia 34 97.96 Very High Very High Very High
Pain 51 91.88 High High
Mycobacterial Infection 2 89.04 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We found that IS potentiated subsequent morphine-induced NAcs DA and this was completely blocked by CORT suppression before morphine, but not before IS.
Negative_regulation (suppression) of CORT in NAcs associated with stress, dopamine and morphine
1) Confidence 0.38 Published 2006 Journal Psychoneuroendocrinology Section Abstract Doc Link 16584846 Disease Relevance 0.85 Pain Relevance 1.55
Restraint decreased milk yield and increased CORT.
Negative_regulation (decreased) of CORT
2) Confidence 0.37 Published 1992 Journal Physiol. Behav. Section Abstract Doc Link 1641416 Disease Relevance 0.25 Pain Relevance 0.18
However, CORT inhibition during IS had no effect on the IS potentiation of morphine CPP, whereas inhibition during morphine administration completely blocked this potentiation.
Negative_regulation (inhibition) of CORT
3) Confidence 0.37 Published 2005 Journal Psychopharmacology (Berl.) Section Body Doc Link 15821955 Disease Relevance 0.07 Pain Relevance 0
In ADX rats, plasma CORT significantly (P < 0.05) decreased from baseline 7 days post-ADX, from 5087.85 ± 1017.64 to 394.78 ± 103.14 ng/ml.
Negative_regulation (decreased) of CORT in plasma
4) Confidence 0.29 Published 2007 Journal BMC Complement Altern Med Section Body Doc Link PMC1976320 Disease Relevance 0.71 Pain Relevance 0.91
Blood was withdrawn and CORT was measured as above on day 7 post-ADX.

2.5 Inflammation and hyperalgesia testing

Negative_regulation (measured) of CORT in Blood associated with hyperalgesia and inflammation
5) Confidence 0.28 Published 2007 Journal BMC Complement Altern Med Section Body Doc Link PMC1976320 Disease Relevance 0.50 Pain Relevance 0.36
In plasma CORT levels, DEX pretreatment dose dependently suppressed the restraint stress-induced increased plasma CORT concentration regardless of prenatal drug exposure.
Negative_regulation (suppressed) of CORT in plasma associated with newborn drug withdrawal syndrome, stress and dexamethasone
6) Confidence 0.26 Published 2003 Journal Neuroendocrinology Section Abstract Doc Link 14688444 Disease Relevance 0.88 Pain Relevance 0.72
However, with the prolongation of the treatment (day 28) only subjects under DEX treatment maintained the significant increase in TF thresholds; in contrast in CORT-treated animals nociceptive behaviour decreased slightly (ANOVAow, P = 0.0003, pos-hoc Bonferroni, CORT × CONT, p > 0.05, DEX × CONT, p < 0.001 and DEX × CORT, p < 0.001) (Fig. 1B).


Negative_regulation (decreased) of CORT associated with nociception, polycystic ovary syndrome and dexamethasone
7) Confidence 0.17 Published 2009 Journal Mol Pain Section Body Doc Link PMC2727498 Disease Relevance 0.77 Pain Relevance 0.97
Notably, we observed a mild decrease (around 15%-30%) in ACTH and CORT levels in plasma after U75302 block of the endogenous LTB4 receptor.
Negative_regulation (decrease) of CORT in plasma
8) Confidence 0.08 Published 2010 Journal J Neuroinflammation Section Body Doc Link PMC2834663 Disease Relevance 0.74 Pain Relevance 0.28
The expression of CGRP-IR was significantly decreased in both DEX and CORT-treated animals when compared to CONT on day 21 (ANOVA2 w, p < 0.0001, pos-hoc Bonferroni, CORT × CONT, p < 0.01 and DEX × CONT, p < 0.001) (Fig. 2A) although this effect was sustained only in DEX animals on day 28 (ANOVA2 w, p < 0.036, pos-hoc Bonferroni, DEX × CONT, p < 0.05) (Fig. 2E).
Negative_regulation (decreased) of CORT associated with polycystic ovary syndrome, dexamethasone and calcitonin gene-related peptide
9) Confidence 0.07 Published 2009 Journal Mol Pain Section Body Doc Link PMC2727498 Disease Relevance 0.49 Pain Relevance 0.97
Pretreatment with U75302 (100 ng i.c.v.) produced significant decreases in plasma CORT and ACTH levels compared with OVA-vehicle after antigen challenge (P < 0.05).
Negative_regulation (decreases) of plasma CORT in plasma
10) Confidence 0.07 Published 2010 Journal J Neuroinflammation Section Body Doc Link PMC2834663 Disease Relevance 0.06 Pain Relevance 0.03
Unlike adipocyte leptin mRNA, serum leptin increased at 2300 h, 4 h after initiation of ingestive behavior. 6) In FR rats, adipocyte leptin gene expression fluctuated little over the 24-h period but, as in FF rats, leptin hypersecretion peaked 4 h after initiation of food intake. 7) In both FF and FR rats, increased serum CORT levels preceded serum leptin rise.
Negative_regulation (preceded) of serum CORT in adipocyte associated with eating disorder
11) Confidence 0.04 Published 1999 Journal Endocrinology Section Abstract Doc Link 10342879 Disease Relevance 0.57 Pain Relevance 0.10

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