INT123164

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Context Info
Confidence 0.04
First Reported 2005
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 2
Total Number 2
Disease Relevance 0.34
Pain Relevance 0.05

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (Arg2)
Anatomy Link Frequency
macrophages 1
Arg2 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Inflammatory response 1 91.28 High High
peptic ulcer disease 1 25.00 Low Low
Inflammation 4 5.00 Very Low Very Low Very Low
spinal inflammation 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
INFLAMMATION 5 90.92 High High
Infection 1 87.76 High High
Ulcers 3 87.36 High High
Ankylosing Spondylitis 3 5.00 Very Low Very Low Very Low
Disease 3 5.00 Very Low Very Low Very Low
Rheumatic Diseases 3 5.00 Very Low Very Low Very Low
Stomach Cancer 1 5.00 Very Low Very Low Very Low
Congenital Anomalies 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
For the B*2705 allele, more extensive hydrogen bonding is observed between the peptide and the protein: In Figure 7A, ARG5 of the peptide binds to ASN97 and ASP116; in Figure 7B, ARG1 of the peptide binds to GLU163; in Figure 7C, ARG2 of the peptide binds to THR24; in Figure 7D, ARG2 of the peptide is bonded to TYR7 and LYS3 of the peptide is bonded to TYR99.
Positive_regulation (bonded) of ARG2
1) Confidence 0.04 Published 2010 Journal PLoS Computational Biology Section Body Doc Link PMC2900293 Disease Relevance 0 Pain Relevance 0
We have reported that in macrophages, H. pylori up-regulates inducible NO synthase (iNOS) and antimicrobial NO production, but in parallel there is induction of arginase II, generating ornithine, and of ornithine decarboxylase (ODC), generating polyamines.
Positive_regulation (induction) of arginase II in macrophages
2) Confidence 0.02 Published 2005 Journal J. Biol. Chem. Section Abstract Doc Link 15548540 Disease Relevance 0.34 Pain Relevance 0.05

General Comments

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