INT12318

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Context Info
Confidence 0.43
First Reported 1989
Last Reported 2010
Negated 1
Speculated 0
Reported most in Abstract
Documents 7
Total Number 7
Disease Relevance 3.89
Pain Relevance 2.65

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (Cort)
Anatomy Link Frequency
plasma 6
adipocyte 2
Cort (Rattus norvegicus)
Pain Link Frequency Relevance Heat
dexamethasone 12 99.38 Very High Very High Very High
Glutamate 66 95.56 Very High Very High Very High
Morphine 14 92.16 High High
Pain 6 91.88 High High
opiate 1 90.80 High High
monoamine 1 85.64 High High
Opioid 2 82.00 Quite High
spastic colon 17 81.76 Quite High
corticosteroid 1 80.96 Quite High
amygdala 44 80.48 Quite High
Disease Link Frequency Relevance Heat
Stress 147 100.00 Very High Very High Very High
Shock 5 100.00 Very High Very High Very High
Eating Disorder 8 99.86 Very High Very High Very High
Newborn Drug Withdrawal Syndrome 2 98.84 Very High Very High Very High
Pain 7 91.88 High High
Irritable Bowel Syndrome /

Irritable Bowel Syndrome Super

60 87.28 High High
Congenital Anomalies 3 80.00 Quite High
Urological Neuroanatomy 8 74.44 Quite High
Nociception 2 73.32 Quite High
Dyspepsia 1 70.16 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We found that all drug treatments employed here did not block either elevation of circulating levels of CORT or accumulation of SNARE complexes in presynaptic membranes, suggesting that the dampening action of drugs on glutamate release must be on pathways located downstream of these processes and/or on alternative pathways.
Negative_regulation (block) of Positive_regulation (elevation) of CORT associated with glutamate
1) Confidence 0.43 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2797327 Disease Relevance 0.37 Pain Relevance 0.32
Restraint decreased milk yield and increased CORT.
Negative_regulation (decreased) of Positive_regulation (increased) of CORT
2) Confidence 0.37 Published 1992 Journal Physiol. Behav. Section Abstract Doc Link 1641416 Disease Relevance 0.25 Pain Relevance 0.18
In plasma CORT levels, DEX pretreatment dose dependently suppressed the restraint stress-induced increased plasma CORT concentration regardless of prenatal drug exposure.
Negative_regulation (suppressed) of Positive_regulation (increased) of CORT in plasma associated with newborn drug withdrawal syndrome, stress and dexamethasone
3) Confidence 0.36 Published 2003 Journal Neuroendocrinology Section Abstract Doc Link 14688444 Disease Relevance 0.88 Pain Relevance 0.72
However, NTX significantly attenuated the shock-induced rise in CORT even though NTX alone significantly elevated CORT in the non-shocked controls.
Negative_regulation (attenuated) of Positive_regulation (rise) of CORT associated with shock
4) Confidence 0.34 Published 1989 Journal J. Neuroimmunol. Section Abstract Doc Link 2685041 Disease Relevance 0.19 Pain Relevance 0.19
Although real-time fMRI has been reported in conscious rats by the team of Ferris and co-workers [43]–[45] who acclimated rats to the experimental conditions within the fMRI magnet as demonstrated by a reduction in the elevation in plasma CORT and motor movements, many technical and ethical challenges exist in performing experiments in unanesthetized rats using our experimental paradigm.
Negative_regulation (reduction) of Positive_regulation (elevation) of CORT in plasma
5) Confidence 0.34 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2797306 Disease Relevance 0.54 Pain Relevance 0.41
In plasma CORT levels, DEX pretreatment dose dependently suppressed the restraint stress-induced increased plasma CORT concentration regardless of prenatal drug exposure.
Negative_regulation (suppressed) of Positive_regulation (increased) of CORT in plasma associated with newborn drug withdrawal syndrome, stress and dexamethasone
6) Confidence 0.26 Published 2003 Journal Neuroendocrinology Section Abstract Doc Link 14688444 Disease Relevance 0.88 Pain Relevance 0.72
Unlike adipocyte leptin mRNA, serum leptin increased at 2300 h, 4 h after initiation of ingestive behavior. 6) In FR rats, adipocyte leptin gene expression fluctuated little over the 24-h period but, as in FF rats, leptin hypersecretion peaked 4 h after initiation of food intake. 7) In both FF and FR rats, increased serum CORT levels preceded serum leptin rise.
Negative_regulation (preceded) of Neg (little) Positive_regulation (increased) of serum CORT in adipocyte associated with eating disorder
7) Confidence 0.04 Published 1999 Journal Endocrinology Section Abstract Doc Link 10342879 Disease Relevance 0.57 Pain Relevance 0.10

General Comments

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