INT12319

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Context Info
Confidence 0.61
First Reported 1989
Last Reported 2010
Negated 3
Speculated 2
Reported most in Abstract
Documents 52
Total Number 56
Disease Relevance 22.55
Pain Relevance 29.35

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (Cort)
Anatomy Link Frequency
plasma 11
brain 8
VStr 7
NAcs 2
amygdala 2
Cort (Rattus norvegicus)
Pain Link Frequency Relevance Heat
amygdala 486 100.00 Very High Very High Very High
Calcitonin gene-related peptide 64 100.00 Very High Very High Very High
electroacupuncture 273 99.84 Very High Very High Very High
Pain 106 99.84 Very High Very High Very High
Dopamine 79 99.84 Very High Very High Very High
Dorsal horn 10 99.78 Very High Very High Very High
Inflammation 209 99.74 Very High Very High Very High
agonist 50 99.72 Very High Very High Very High
cocaine 45 99.52 Very High Very High Very High
antidepressant 130 99.44 Very High Very High Very High
Disease Link Frequency Relevance Heat
Stress 805 100.00 Very High Very High Very High
Eating Disorder 8 99.86 Very High Very High Very High
Pain 128 99.84 Very High Very High Very High
Shock 24 99.82 Very High Very High Very High
INFLAMMATION 250 99.74 Very High Very High Very High
Irritable Bowel Syndrome /

Irritable Bowel Syndrome Super

660 99.72 Very High Very High Very High
Urological Neuroanatomy 58 99.52 Very High Very High Very High
Anxiety Disorder 152 98.88 Very High Very High Very High
Newborn Drug Withdrawal Syndrome 2 98.84 Very High Very High Very High
Pressure And Volume Under Development 54 96.64 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Experiments 2 and 3 established that similar effects could be produced by doses of CORT as low as 0.125 mg/kg or by exposure to a novel environment which also elevated CORT levels.
Positive_regulation (elevated) of CORT
1) Confidence 0.61 Published 1993 Journal Psychopharmacology (Berl.) Section Abstract Doc Link 7870994 Disease Relevance 0.07 Pain Relevance 0.76
The highest dose tested (18 nmol) of a mixture of the dopamine D1 receptor agonist SKF 38393 and the D2 agonist quinpirole (SKF/Quin) increased plasma CORT when injected into each of the three brain regions.
Positive_regulation (increased) of CORT in brain associated with dopamine and agonist
2) Confidence 0.59 Published 1998 Journal Brain Res. Section Abstract Doc Link 9838097 Disease Relevance 0 Pain Relevance 0.71
These results suggest that the VStr plays an important role in mediating the elevated plasma CORT induced by DA agonists and cocaine administration.
Positive_regulation (elevated) of CORT in VStr associated with dopamine, agonist and cocaine
3) Confidence 0.59 Published 1998 Journal Brain Res. Section Abstract Doc Link 9838097 Disease Relevance 0 Pain Relevance 0.81
These results suggest that the VStr plays an important role in mediating the elevated plasma CORT induced by DA agonists and cocaine administration.
Positive_regulation (induced) of CORT in VStr associated with dopamine, agonist and cocaine
4) Confidence 0.59 Published 1998 Journal Brain Res. Section Abstract Doc Link 9838097 Disease Relevance 0 Pain Relevance 0.81
Microinjections of the medium dose (i.e., 3 nmol) of SKF/Quin into the VStr also increased plasma CORT, while the injections into the MPC and DStr did not.
Positive_regulation (increased) of CORT in VStr
5) Confidence 0.59 Published 1998 Journal Brain Res. Section Abstract Doc Link 9838097 Disease Relevance 0 Pain Relevance 0.80
In view of our initial observation of a greater increase in total brain activation in response to CRD in rats with elevated amygdala CORT for 7 days, we attempted to systematically examine specific brain nuclei that showed activation in CORT-treated rats but not in CHOL-implanted rats to gain a more complete picture of the central nuclei activated by CRD in the 2 groups.
Positive_regulation (elevated) of CORT in amygdala associated with amygdala
6) Confidence 0.54 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2797306 Disease Relevance 0.05 Pain Relevance 0.15
We found that all drug treatments employed here did not block either elevation of circulating levels of CORT or accumulation of SNARE complexes in presynaptic membranes, suggesting that the dampening action of drugs on glutamate release must be on pathways located downstream of these processes and/or on alternative pathways.
Positive_regulation (elevation) of CORT associated with glutamate
7) Confidence 0.51 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2797327 Disease Relevance 0.37 Pain Relevance 0.32
Because CORT is mainly secreted by the adrenals and has potent anti-inflammatory effects, an increase of plasma CORT after EA treatment suggests that EA activates the adrenals to suppress CFA-induced edema.
Positive_regulation (increase) of CORT in plasma associated with pressure and volume under development, inflammation and electroacupuncture
8) Confidence 0.46 Published 2007 Journal BMC Complement Altern Med Section Body Doc Link PMC1976320 Disease Relevance 0.89 Pain Relevance 1.09
INTRODUCTION: This study aimed to determine whether the previously reported differential effects of estradiol on inflammation-induced behavioral responses are in part explained through differential activation of the corticosterone-cyclooxygenase (CORT-COX) regulatory pathway.
Positive_regulation (activation) of CORT associated with inflammation
9) Confidence 0.46 Published 2010 Journal Ethn Dis Section Abstract Doc Link 20521385 Disease Relevance 0.17 Pain Relevance 0.09
In plasma CORT levels, DEX pretreatment dose dependently suppressed the restraint stress-induced increased plasma CORT concentration regardless of prenatal drug exposure.
Positive_regulation (increased) of CORT in plasma associated with newborn drug withdrawal syndrome, stress and dexamethasone
10) Confidence 0.42 Published 2003 Journal Neuroendocrinology Section Abstract Doc Link 14688444 Disease Relevance 0.86 Pain Relevance 0.71
However, elevated levels of CORT concurrent with morphine, but in the absence of a stressor, failed to potentiate NAcs DA or CPP.
Positive_regulation (elevated) of CORT in NAcs associated with dopamine and morphine
11) Confidence 0.41 Published 2006 Journal Psychoneuroendocrinology Section Abstract Doc Link 16584846 Disease Relevance 0.84 Pain Relevance 1.54
Here, we test (1) the necessity of CORT during inescapable stress (IS) and/or morphine for IS potentiation of morphine-induced NAcs DA and (2) the sufficiency of enhanced CORT, in the absence of prior IS, to potentiate morphine-induced NAcs DA as well as morphine conditioned place preference (CPP) in male Sprague-Dawley rats.
Positive_regulation (enhanced) of CORT in NAcs associated with stress, dopamine and morphine
12) Confidence 0.41 Published 2006 Journal Psychoneuroendocrinology Section Abstract Doc Link 16584846 Disease Relevance 0.70 Pain Relevance 1.14
Other investigators have suggested that tolerance to multiple nicotine injections in mice may be due, in part, to elevated plasma corticosterone (CORT) levels, since repeated nicotine injections are associated with elevated CORT, chronically elevated CORT reduces nicotine responsiveness and adrenalectomy disrupts nicotine tolerance.
Positive_regulation (elevated) of CORT in plasma associated with nicotine and tolerance
13) Confidence 0.41 Published 1993 Journal Psychopharmacology (Berl.) Section Abstract Doc Link 7870994 Disease Relevance 0.07 Pain Relevance 0.62
Results also suggest that a conditioned release of endogenous CORT was triggered by stimuli associated with nicotine delivery.
Positive_regulation (triggered) of CORT associated with nicotine
14) Confidence 0.41 Published 1993 Journal Psychopharmacology (Berl.) Section Abstract Doc Link 7870994 Disease Relevance 0.07 Pain Relevance 0.70
A similar reduction was produced by the vehicle pretreatment, which itself induced an elevation of endogenous CORT.
Positive_regulation (elevation) of CORT
15) Confidence 0.41 Published 1993 Journal Psychopharmacology (Berl.) Section Abstract Doc Link 7870994 Disease Relevance 0.07 Pain Relevance 0.83
Other investigators have suggested that tolerance to multiple nicotine injections in mice may be due, in part, to elevated plasma corticosterone (CORT) levels, since repeated nicotine injections are associated with elevated CORT, chronically elevated CORT reduces nicotine responsiveness and adrenalectomy disrupts nicotine tolerance.
Positive_regulation (elevated) of CORT in plasma associated with nicotine and tolerance
16) Confidence 0.41 Published 1993 Journal Psychopharmacology (Berl.) Section Abstract Doc Link 7870994 Disease Relevance 0.07 Pain Relevance 0.72
These findings of organ weight changes, enhanced basal CORT, and reduced CORT response to stress in a subgroup of animals are similar to many of the phenomena obtained with other intense, chronic stressors such as subordination, and suggest that repeated predator exposure produces a pattern of intense behavioral and endocrine response that is very slow to habituate.
Positive_regulation (enhanced) of CORT associated with stress
17) Confidence 0.40 Published 1998 Journal Physiol. Behav. Section Abstract Doc Link 9523899 Disease Relevance 0.39 Pain Relevance 0.14
Of the 13 cat-exposed subjects, 6 (and a single control) failed to show a 10 microg/mL corticosterone (CORT) increase in response to an acute restraint stressor.
Positive_regulation (increase) of CORT
18) Confidence 0.40 Published 1998 Journal Physiol. Behav. Section Abstract Doc Link 9523899 Disease Relevance 0.32 Pain Relevance 0.08
Further, stress-induced CORT-release seems to be involved in stress-induced behavioural sensitization to morphine.
Positive_regulation (induced) of CORT-release associated with stress and morphine
19) Confidence 0.40 Published 1999 Journal Behav. Brain Res. Section Abstract Doc Link 10475168 Disease Relevance 0.97 Pain Relevance 0.91
Restraint decreased milk yield and increased CORT.
Positive_regulation (increased) of CORT
20) Confidence 0.40 Published 1992 Journal Physiol. Behav. Section Abstract Doc Link 1641416 Disease Relevance 0.25 Pain Relevance 0.18

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