INT123198

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Context Info
Confidence 0.81
First Reported 2004
Last Reported 2010
Negated 0
Speculated 1
Reported most in Abstract
Documents 6
Total Number 9
Disease Relevance 3.24
Pain Relevance 1.53

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transmembrane transport (TRPM8)
Anatomy Link Frequency
reticulum 3
sensory neurons 1
plasma 1
bladder 1
TRPM8 (Homo sapiens)
Pain Link Frequency Relevance Heat
member 8 11 100.00 Very High Very High Very High
Cholecystokinin 1 100.00 Very High Very High Very High
allodynia 7 99.92 Very High Very High Very High
TRP channel 11 90.08 High High
pruritus 2 76.88 Quite High
Pain 36 75.92 Quite High
Inflammation 10 75.00 Quite High
visual analogue scale 10 73.56 Quite High
unmyelinated 6 64.32 Quite High
c fibre 12 63.28 Quite High
Disease Link Frequency Relevance Heat
Neuropathic Pain 9 99.92 Very High Very High Very High
Hypersensitivity 2 98.84 Very High Very High Very High
Reprotox - General 1 25 98.36 Very High Very High Very High
Breast Cancer 75 97.84 Very High Very High Very High
Frostbite 5 97.60 Very High Very High Very High
Pruritus 4 76.88 Quite High
Pain 28 75.92 Quite High
Neurogenic Inflammation 2 75.00 Quite High
Cancer 48 66.00 Quite High
Dermatitis 1 63.04 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We demonstrate that these puzzling results arise from TRPM8 localization not in the plasma, but in the endoplasmic reticulum (ER) membrane of LNCaP cells, where it supports cold/menthol/icilin-induced Ca(2+) release from the ER with concomitant activation of plasma membrane (PM) store-operated channels (SOC).
Localization (localization) of TRPM8 in plasma
1) Confidence 0.81 Published 2005 Journal J. Biol. Chem. Section Abstract Doc Link 16174775 Disease Relevance 0.15 Pain Relevance 0.15
In LNCaP cells, two studies have reported dual localization of TRPM8 channels in the plasma membrane (PMTRPM8) and endoplasmic reticulum (ERTRPM8).
Localization (localization) of TRPM8 in reticulum
2) Confidence 0.80 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2887400 Disease Relevance 0.40 Pain Relevance 0
In LNCaP cells, two studies have reported dual localization of TRPM8 channels in the plasma membrane (PMTRPM8) and endoplasmic reticulum (ERTRPM8).
Localization (localization) of TRPM8 in reticulum
3) Confidence 0.78 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2887400 Disease Relevance 0.46 Pain Relevance 0
In LNCaP cells, two studies have reported dual localization of TRPM8 channels in the plasma membrane (PMTRPM8) and endoplasmic reticulum (ERTRPM8).
Localization (localization) of TRPM8 in reticulum
4) Confidence 0.78 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2887400 Disease Relevance 0.47 Pain Relevance 0
While they showed that TRPM8 was localized within the bladder urothelial layer, in our study TRPM8 immunoreactive fibres were seen scattered in the suburothelium and nerve bundles, in addition to urothelial staining.
Localization (localized) of TRPM8 in bladder
5) Confidence 0.71 Published 2006 Journal BMC Urol Section Body Doc Link PMC1420318 Disease Relevance 0.14 Pain Relevance 0.30
We have investigated the intracellular location of TRPM8 and its role as a Ca(2+)-permeable channel in an androgen-responsive and an androgen-insensitive prostate cancer cell line.
Spec (investigated) Localization (location) of TRPM8 associated with reprotox - general 1
6) Confidence 0.70 Published 2004 Journal Cancer Res. Section Abstract Doc Link 15548706 Disease Relevance 0.27 Pain Relevance 0
Sensitisation of TRPM8 or TRPA1 could be the underlying mechanisms.
Localization (Sensitisation) of TRPM8
7) Confidence 0.69 Published 2008 Journal Pain Section Abstract Doc Link 18440147 Disease Relevance 0.74 Pain Relevance 0.28
The authors demonstrate the successful and rapid retargeting of a G-protein-coupled receptor (cholecystokinin receptor A, CCKAR), an ion channel (the transient receptor potential cation channel, subfamily M, member 8, TRPM8), and a GFP-c-Jun(1-79) fusion protein into the specific loci in these cell lines and show that these retargeted cell lines exhibit functional and pharmacological responses consistent with those reported in the literature.
Localization (retargeting) of TRPM8 associated with member 8 and cholecystokinin
8) Confidence 0.53 Published 2009 Journal J Biomol Screen Section Abstract Doc Link 19820070 Disease Relevance 0 Pain Relevance 0.35
The temperature-sensitive transient receptor potential (TRP) channels, is also called thermo TRP, including TRPV1, TRPV2, TRPV3, TRPV4, TRPM8 and TRPA1, which are expressed in sensory neurons and non-neuronal cells (e.g.keratinocyte, mast cell) of the skin.
Localization (called) of TRPM8 in sensory neurons
9) Confidence 0.17 Published 2009 Journal Zhejiang Da Xue Xue Bao Yi Xue Ban Section Abstract Doc Link 19693981 Disease Relevance 0.61 Pain Relevance 0.45

General Comments

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