INT1232

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Context Info
Confidence 0.42
First Reported 1976
Last Reported 2010
Negated 5
Speculated 2
Reported most in Abstract
Documents 78
Total Number 80
Disease Relevance 24.33
Pain Relevance 50.17

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Pdpk1) cytoplasmic membrane-bounded vesicle (Pdpk1) plasma membrane (Pdpk1)
nucleus (Pdpk1) kinase activity (Pdpk1) cytoplasm (Pdpk1)
Anatomy Link Frequency
neurons 7
spinal cord 4
lateral 3
paw 3
vagus nerve 2
Pdpk1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Kinase C 171 100.00 Very High Very High Very High
Pain 62 100.00 Very High Very High Very High
qutenza 43 100.00 Very High Very High Very High
nMDA receptor 29 100.00 Very High Very High Very High
adenocard 27 100.00 Very High Very High Very High
nociceptor 25 100.00 Very High Very High Very High
Neurotransmitter 18 100.00 Very High Very High Very High
Kinase C inhibitor 14 100.00 Very High Very High Very High
Inflammation 194 99.92 Very High Very High Very High
Gabapentin 4 99.84 Very High Very High Very High
Disease Link Frequency Relevance Heat
INFLAMMATION 164 99.92 Very High Very High Very High
Hyperalgesia 142 99.80 Very High Very High Very High
Stress 21 98.90 Very High Very High Very High
Pressure Volume 2 Under Development 4 98.88 Very High Very High Very High
Pain 73 98.52 Very High Very High Very High
Nociception 93 97.82 Very High Very High Very High
Drug Dependence 3 96.64 Very High Very High Very High
Reperfusion Injury 10 95.52 Very High Very High Very High
Neuropathic Pain 71 95.36 Very High Very High Very High
Anxiety Disorder 77 94.96 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We found no significant inhibition of activation of protein kinase in the above experimental conditions.
Positive_regulation (activation) of protein kinase
1) Confidence 0.42 Published 1976 Journal Biochim. Biophys. Acta Section Abstract Doc Link 179578 Disease Relevance 0 Pain Relevance 0.16
Therefore, we examined whether the inhibition of the gluconeogenic response in the liver is due to an interference with the activation of protein kinase in the following situations: (1) adrenalectomy, (2) Na+-free perfusate, (3) administration of local anesthetic.
Positive_regulation (activation) of protein kinase in liver associated with local anesthetic
2) Confidence 0.42 Published 1976 Journal Biochim. Biophys. Acta Section Abstract Doc Link 179578 Disease Relevance 0 Pain Relevance 0.10
It seems that in the intact liver, activation of protein kinase by itself is not sufficient to evoke metabolic responses.
Spec (seems) Positive_regulation (activation) of protein kinase in liver
3) Confidence 0.42 Published 1976 Journal Biochim. Biophys. Acta Section Abstract Doc Link 179578 Disease Relevance 0 Pain Relevance 0.17
Preventing the activation of protein kinase G by injecting Rp-8-pCPT-cGMPS into the crush site abolished the transport.
Positive_regulation (activation) of protein kinase
4) Confidence 0.41 Published 2006 Journal Neuroscience Section Abstract Doc Link 16730916 Disease Relevance 0.93 Pain Relevance 0.47
We therefore injected complete Freund's adjuvant into the hindpaw to induce an inflammation and found that protein kinase G was activated in the sural nerve and transported to the DRG.
Positive_regulation (activated) of protein kinase in nerve associated with inflammation
5) Confidence 0.41 Published 2006 Journal Neuroscience Section Abstract Doc Link 16730916 Disease Relevance 0.57 Pain Relevance 0.43
Crushing the sciatic nerve or a cutaneous sensory nerve activates protein kinase G in axons and results in its retrograde transport to the neuronal somata in the DRG.
Positive_regulation (activates) of protein kinase in neuronal associated with sciatic nerve
6) Confidence 0.36 Published 2006 Journal Neuroscience Section Abstract Doc Link 16730916 Disease Relevance 0.94 Pain Relevance 0.49
Activation of protein kinase A and C markedly enhanced the effect of GBR-12909, whereas protein kinase inhibition by H7 reduced the GBR-12909 effect.
Positive_regulation (Activation) of protein kinase
7) Confidence 0.35 Published 2002 Journal Synapse Section Abstract Doc Link 12211084 Disease Relevance 0 Pain Relevance 0.48
This was accompanied by a significant increase in total functional membrane-associated protein kinase C activity, whereas total cytosolic protein kinase C activity was unchanged on the sides of the lumbar spinal cord both contralateral and ipsilateral to the inflammation.
Positive_regulation (increase) of protein kinase in spinal cord associated with kinase c, inflammation and spinal cord
8) Confidence 0.34 Published 2001 Journal Neuroscience Section Abstract Doc Link 11440817 Disease Relevance 0.91 Pain Relevance 1.19
Time-course for increases in the activity of membrane-associated protein kinase CbetaII, and in intensity of protein kinase CbetaII-immunoreactivity, paralleled inflammation-mediated changes in paw withdrawal latency and paw diameter.
Positive_regulation (increases) of protein kinase in paw associated with inflammation and withdrawal
9) Confidence 0.34 Published 2001 Journal Neuroscience Section Abstract Doc Link 11440817 Disease Relevance 0.72 Pain Relevance 1.00
However, membrane-associated activity of protein kinase CbetaII was increased in the cord section ipsilateral to the inflammation, suggesting that increased translocation/activation of protein kinase CbetaII is related to thermal hyperalgesia.
Positive_regulation (increased) of protein kinase associated with inflammation and thermal hyperalgesia
10) Confidence 0.26 Published 2006 Journal Neuroscience Section Abstract Doc Link 16360284 Disease Relevance 0.58 Pain Relevance 0.76
However, membrane-associated activity of protein kinase CbetaII was increased in the cord section ipsilateral to the inflammation, suggesting that increased translocation/activation of protein kinase CbetaII is related to thermal hyperalgesia.
Positive_regulation (translocation/activation) of protein kinase associated with inflammation and thermal hyperalgesia
11) Confidence 0.26 Published 2006 Journal Neuroscience Section Abstract Doc Link 16360284 Disease Relevance 0.58 Pain Relevance 0.78
Crushing the sciatic nerve or a cutaneous sensory nerve activates protein kinase G in axons and results in its retrograde transport to the neuronal somata in the DRG.
Positive_regulation (results) of protein kinase in neuronal associated with sciatic nerve
12) Confidence 0.26 Published 2006 Journal Neuroscience Section Abstract Doc Link 16730916 Disease Relevance 0.94 Pain Relevance 0.49
Thus, acute applications of desipramine stimulated the ongoing neurotransmitter release pathway, probably by activating protein kinase C.
Positive_regulation (activating) of protein kinase associated with kinase c, neurotransmitter and desipramine
13) Confidence 0.25 Published 1999 Journal Neuroscience Section Abstract Doc Link 10218774 Disease Relevance 0 Pain Relevance 0.85
Furthermore, the action on glutamate release might be increased by the enhancement of cAMP-dependent protein kinase and/or protein kinase C activity.
Positive_regulation (enhancement) of protein kinase associated with kinase c and glutamate
14) Confidence 0.25 Published 1998 Journal J. Biomed. Sci. Section Abstract Doc Link 9570513 Disease Relevance 0.25 Pain Relevance 1.54
Importantly, on the side of lumbar cord ipsilateral to the inflamed paw, the activity of membrane-associated protein kinase CbetaII was increased following the same time-course as the paw withdrawal latency decrease, suggesting an increased translocation of protein kinase Cbetall to the membrane related to behavioral hyperalgesia.
Positive_regulation (increased) of protein kinase in paw associated with hyperalgesia and withdrawal
15) Confidence 0.24 Published 2001 Journal Neuroscience Section Abstract Doc Link 11440817 Disease Relevance 0.98 Pain Relevance 1.26
This was accompanied by a significant increase in total functional membrane-associated protein kinase C activity, whereas total cytosolic protein kinase C activity was unchanged on the sides of the lumbar spinal cord both contralateral and ipsilateral to the inflammation.
Neg (unchanged) Positive_regulation (unchanged) of protein kinase in spinal cord associated with kinase c, inflammation and spinal cord
16) Confidence 0.24 Published 2001 Journal Neuroscience Section Abstract Doc Link 11440817 Disease Relevance 0.94 Pain Relevance 1.23
Chronic alcohol intake is known to decrease the nociceptive threshold with increased oxidative-nitrosative stress and release of proinflammatory cytokines coupled with activation of protein kinase C.
Positive_regulation (activation) of protein kinase associated with stress, nociception, kinase c, cytokine and alcohol
17) Confidence 0.23 Published 2009 Journal Pain Section Abstract Doc Link 19541419 Disease Relevance 1.09 Pain Relevance 1.09
Moreover, the inhibitory effect of mu opioid receptors on Ca2+ currents required the activation of protein kinase A.
Positive_regulation (activation) of protein kinase associated with mu opioid receptor
18) Confidence 0.22 Published 2008 Journal Acta Neurobiol Exp (Wars) Section Abstract Doc Link 18389010 Disease Relevance 0 Pain Relevance 0.49
Furthermore, the action on glutamate release might be increased by the enhancement of cAMP-dependent protein kinase and/or protein kinase C activity.
Positive_regulation (enhancement) of protein kinase associated with kinase c and glutamate
19) Confidence 0.22 Published 1998 Journal J. Biomed. Sci. Section Abstract Doc Link 9570513 Disease Relevance 0.25 Pain Relevance 1.54
Pregabalin and gabapentin reduce release of substance P and CGRP from rat spinal tissues only after inflammation or activation of protein kinase C.
Positive_regulation (activation) of protein kinase in spinal associated with pregabalin, kinase c, inflammation, gabapentin and substance p
20) Confidence 0.22 Published 2003 Journal Pain Section Title Doc Link 14499429 Disease Relevance 0.19 Pain Relevance 1.56

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