INT12320

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Context Info
Confidence 0.38
First Reported 1992
Last Reported 2008
Negated 1
Speculated 0
Reported most in Abstract
Documents 3
Total Number 3
Disease Relevance 1.29
Pain Relevance 0.56

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endoplasmic reticulum (Nr3c2) nucleus (Nr3c2) cytoplasm (Nr3c2)
Anatomy Link Frequency
autonomic 2
Nr3c2 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
corticosteroid 14 88.40 High High
Hippocampus 29 88.20 High High
fluoxetine 1 76.52 Quite High
Serotonin 2 75.00 Quite High
depression 2 72.40 Quite High
Pain 2 71.04 Quite High
dexamethasone 1 59.52 Quite High
opiate 1 42.16 Quite Low
Neurotransmitter 1 30.72 Quite Low
anesthesia 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Post-traumatic Stress Disorder 27 100.00 Very High Very High Very High
Anxiety Disorder 10 99.28 Very High Very High Very High
Nociception 1 98.80 Very High Very High Very High
Stress 56 84.56 Quite High
Depression 2 72.40 Quite High
Pain 1 71.04 Quite High
Death 3 5.00 Very Low Very Low Very Low
Neurodegenerative Disease 2 5.00 Very Low Very Low Very Low
Syndrome 2 5.00 Very Low Very Low Very Low
Apoptosis 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
A decrease of hippocampal MR in PTSD could be responsible for the related clinical phenomena including increased startle-response, enhanced autonomic reactivity, hypervigilance, and increased anxiety.
Regulation (responsible) of Negative_regulation (decrease) of MR in autonomic associated with post-traumatic stress disorder and anxiety disorder
1) Confidence 0.38 Published 2008 Journal Acta Histochemica et Cytochemica Section Body Doc Link PMC2532603 Disease Relevance 1.04 Pain Relevance 0.23
PCA produced an 87% decrease in hippocampal 5-HT and 5-HIAA levels, but did not alter hippocampal GR or MR levels.
Neg (not) Regulation (alter) of Negative_regulation (hippocampal) of MR
2) Confidence 0.27 Published 1995 Journal Brain Res. Section Abstract Doc Link 7583200 Disease Relevance 0 Pain Relevance 0.26
The role of the ensuing adrenocortical response in the suppression of MR was also evaluated.
Regulation (role) of Negative_regulation (suppression) of MR
3) Confidence 0.14 Published 1992 Journal Physiol. Behav. Section Abstract Doc Link 1641416 Disease Relevance 0.25 Pain Relevance 0.07

General Comments

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