INT12321

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Context Info
Confidence 0.46
First Reported 1983
Last Reported 2010
Negated 1
Speculated 1
Reported most in Abstract
Documents 19
Total Number 21
Disease Relevance 5.44
Pain Relevance 13.46

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endoplasmic reticulum (Nr3c2) nucleus (Nr3c2) cytoplasm (Nr3c2)
Anatomy Link Frequency
hippocampus 2
hypothalamus 1
brain 1
Nr3c2 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
corticosteroid 74 100.00 Very High Very High Very High
Opioid 12 100.00 Very High Very High Very High
excitatory amino acid 18 99.98 Very High Very High Very High
narcan 12 99.92 Very High Very High Very High
dexamethasone 87 99.80 Very High Very High Very High
Hippocampus 61 99.76 Very High Very High Very High
Morphine 54 99.62 Very High Very High Very High
Calcium channel 7 99.54 Very High Very High Very High
opiate 25 99.44 Very High Very High Very High
antagonist 17 99.20 Very High Very High Very High
Disease Link Frequency Relevance Heat
Stress 110 99.78 Very High Very High Very High
Post-traumatic Stress Disorder 27 94.04 High High
Decapitation 6 93.20 High High
Cognitive Disorder 1 87.44 High High
Hypertension 2 85.76 High High
Hyperalgesia 2 85.00 Quite High
Nociception 51 84.28 Quite High
Weight Gain 2 82.24 Quite High
Pain 47 81.52 Quite High
Pressure And Volume Under Development 2 80.72 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The binding to rat brain homogenates of Mr2034, a universal opiate.
Mr2034 Binding (binding) of in brain associated with narcan and opiate
1) Confidence 0.46 Published 1983 Journal Life Sci. Section Title Doc Link 6310291 Disease Relevance 0 Pain Relevance 0.91
Therefore, the present study examined the binding characteristics of MR and GR in young adult male and female rats exposed prenatally (E11-E18) to morphine (10 mg/kg/2 x /day), saline or no treatment at all (controls).
MR Spec (examined) Binding (binding) of associated with morphine
2) Confidence 0.44 Published 2006 Journal Int. J. Dev. Neurosci. Section Abstract Doc Link 16698219 Disease Relevance 0.31 Pain Relevance 0.50
In female rats, prenatal morphine exposure does not affect the binding of MR and GR in the hippocampus or GR in the hypothalamus relative to controls; however, they are affected by ovarian hormone fluctuation.
MR Binding (binding) of in hippocampus associated with hippocampus and morphine
3) Confidence 0.44 Published 2006 Journal Int. J. Dev. Neurosci. Section Abstract Doc Link 16698219 Disease Relevance 0.45 Pain Relevance 0.84
The data demonstrate that prenatal stress due to maternal saline injections up-regulates MR and GR binding in the hippocampus of adult male rats and this effect is prevented by prenatal morphine exposure.
MR Binding (binding) of in hippocampus associated with stress, hippocampus and morphine
4) Confidence 0.44 Published 2006 Journal Int. J. Dev. Neurosci. Section Abstract Doc Link 16698219 Disease Relevance 0.40 Pain Relevance 0.76
Progesterone (P) has high affinity to the mineralocorticoid receptor (MCR), and it is an MCR antagonist.
mineralocorticoid receptor Binding (affinity) of associated with antagonist
5) Confidence 0.40 Published 2004 Journal Mol. Cell. Endocrinol. Section Abstract Doc Link 15134826 Disease Relevance 0.16 Pain Relevance 0.05
Progesterone (P) has high affinity to the mineralocorticoid receptor (MCR), and it is an MCR antagonist.
MCR Binding (affinity) of associated with antagonist
6) Confidence 0.40 Published 2004 Journal Mol. Cell. Endocrinol. Section Abstract Doc Link 15134826 Disease Relevance 0.16 Pain Relevance 0.05
Binding studies using [(3)H] aldosterone indicated that benidipine and other calcium channel blockers competed for binding to mineralocorticoid receptor.
mineralocorticoid receptor Binding (binding) of associated with calcium channel
7) Confidence 0.37 Published 2010 Journal Eur. J. Pharmacol. Section Abstract Doc Link 20307534 Disease Relevance 0.34 Pain Relevance 0.49
MR and GR form not only homodimers, but also heterodimers [16, 20].
MR Binding (homodimers) of
8) Confidence 0.36 Published 2008 Journal Acta Histochemica et Cytochemica Section Body Doc Link PMC2532603 Disease Relevance 0.79 Pain Relevance 0.16
Thus, the present study demonstrates that: (1) prenatal stress due to maternal saline injections alters MR and GR binding of adult male and female rats and is prevented by prenatal morphine exposure; (2) the MR and GR binding in adult female rats are affected by ovarian hormone fluctuations.
MR Binding (binding) of associated with stress and morphine
9) Confidence 0.33 Published 2006 Journal Int. J. Dev. Neurosci. Section Abstract Doc Link 16698219 Disease Relevance 0.38 Pain Relevance 0.69
The present findings indicate EAA afferents to the MR normally exert an excitatory influence on the MR in its desynchronization of the hippocampal EEG, whereas the removal of EAA inputs to MR produces the opposite: a reduction of MR activity and hence the elicitation of theta.
MR Binding (afferents) of associated with excitatory amino acid
10) Confidence 0.31 Published 1994 Journal Brain Res. Section Abstract Doc Link 7982102 Disease Relevance 0 Pain Relevance 0.61
The present findings indicate EAA afferents to the MR normally exert an excitatory influence on the MR in its desynchronization of the hippocampal EEG, whereas the removal of EAA inputs to MR produces the opposite: a reduction of MR activity and hence the elicitation of theta.
MR Binding (activity) of associated with excitatory amino acid
11) Confidence 0.31 Published 1994 Journal Brain Res. Section Abstract Doc Link 7982102 Disease Relevance 0 Pain Relevance 0.52
Displacement of 3H-Mr2034 binding by opioids was multiphasic, again implying that 3H-Mr2034 was binding to more than one class, of site.
Mr2034 Binding (binding) of associated with opioid
12) Confidence 0.30 Published 1983 Journal Life Sci. Section Abstract Doc Link 6310291 Disease Relevance 0 Pain Relevance 0.84
A portion of the higher affinity (KD 0.06 nM) component was inhibited by naloxonazine treatment in vitro (50 nM), suggesting that 3H-Mr2034 bound with very high affinity to mu1 sites.
Mr2034 Binding (bound) of
13) Confidence 0.30 Published 1983 Journal Life Sci. Section Abstract Doc Link 6310291 Disease Relevance 0 Pain Relevance 0.82
Saturation studies of 3H-Mr2034 binding demonstrated curvilinear Scatchard plots which could be dissected into two components by computer: KD1 0.06 nM, Bmax1 2.49 fmoles/mg tissue; and KD2 2.4 nM, Bmax2 6.57 fmoles/mg tissue.
Mr2034 Binding (binding) of
14) Confidence 0.30 Published 1983 Journal Life Sci. Section Abstract Doc Link 6310291 Disease Relevance 0 Pain Relevance 0.63
Displacement of 3H-Mr2034 binding by opioids was multiphasic, again implying that 3H-Mr2034 was binding to more than one class, of site.
Mr2034 Binding (binding) of associated with opioid
15) Confidence 0.30 Published 1983 Journal Life Sci. Section Abstract Doc Link 6310291 Disease Relevance 0 Pain Relevance 0.85
Displacement of 3H-Mr2034 binding by opioids was multiphasic, again implying that 3H-Mr2034 was binding to more than one class, of site.
Mr2034 Binding (binding) of associated with opioid
16) Confidence 0.30 Published 1983 Journal Life Sci. Section Abstract Doc Link 6310291 Disease Relevance 0 Pain Relevance 0.83
Moreover, prenatal stress decreases MR binding in the hippocampus of diestrous females and GR binding in the hypothalamus of estrous females.
MR Binding (binding) of in hypothalamus associated with stress and hippocampus
17) Confidence 0.30 Published 2006 Journal Int. J. Dev. Neurosci. Section Abstract Doc Link 16698219 Disease Relevance 0.41 Pain Relevance 0.83
Thus, the present study demonstrates that: (1) prenatal stress due to maternal saline injections alters MR and GR binding of adult male and female rats and is prevented by prenatal morphine exposure; (2) the MR and GR binding in adult female rats are affected by ovarian hormone fluctuations.
MR Binding (binding) of associated with stress and morphine
18) Confidence 0.28 Published 2006 Journal Int. J. Dev. Neurosci. Section Abstract Doc Link 16698219 Disease Relevance 0.40 Pain Relevance 0.71
In conclusion, not all types of aversive stimuli interfere with MR.
MR Binding (interfere) of
19) Confidence 0.20 Published 1992 Journal Physiol. Behav. Section Abstract Doc Link 1641416 Disease Relevance 0.22 Pain Relevance 0.18
Corticosteroids can bind to two types of corticosteroid receptors, mineralocorticoid (MR) and glucocorticoid (GR) receptors.
MR Binding (bind) of associated with corticosteroid
20) Confidence 0.12 Published 2009 Journal Mol Pain Section Body Doc Link PMC2727498 Disease Relevance 0.80 Pain Relevance 1.30

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