INT123223

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Context Info
Confidence 0.35
First Reported 2005
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 5
Total Number 5
Disease Relevance 3.36
Pain Relevance 1.65

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (TNFAIP6) cell adhesion (TNFAIP6) cell-cell signaling (TNFAIP6)
Anatomy Link Frequency
intervertebral disc 2
proximal 1
TNFAIP6 (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 14 100.00 Very High Very High Very High
Sciatica 6 100.00 Very High Very High Very High
cytokine 5 100.00 Very High Very High Very High
fibrosis 3 99.58 Very High Very High Very High
Pain 5 92.92 High High
rheumatoid arthritis 2 78.60 Quite High
Nicotine 48 5.00 Very Low Very Low Very Low
metalloproteinase 3 5.00 Very Low Very Low Very Low
endometriosis 2 5.00 Very Low Very Low Very Low
Cannabinoid receptor 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cancer 16 100.00 Very High Very High Very High
Necrosis 8 100.00 Very High Very High Very High
Internal Fibrosis 2 99.58 Very High Very High Very High
Dermal Scarring 48 97.40 Very High Very High Very High
INFLAMMATION 8 96.76 Very High Very High Very High
Disease 29 94.28 High High
Pain 5 92.92 High High
Targeted Disruption 2 89.36 High High
Rheumatoid Arthritis 2 78.60 Quite High
Adhesions 48 75.52 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
TNFalpha-stimulated gene product (TSG-6) and its binding protein, IalphaI, in the human intervertebral disc: new molecules for the disc.
TNFalpha-stimulated gene product Binding (binding) of in intervertebral disc associated with cytokine
1) Confidence 0.35 Published 2005 Journal Eur Spine J Section Title Doc Link 15549486 Disease Relevance 0.73 Pain Relevance 0.75
TNFalpha-stimulated gene product (TSG-6) and its binding protein, IalphaI, in the human intervertebral disc: new molecules for the disc.
TSG-6 Binding (binding) of in intervertebral disc associated with cytokine
2) Confidence 0.35 Published 2005 Journal Eur Spine J Section Title Doc Link 15549486 Disease Relevance 0.73 Pain Relevance 0.75
TNFAIP6 was shown to be involved in the inhibition of neutrophil migration, modulation of inflammation, and tissue remodeling.38 In individuals with renal fibrosis, increased expression of TNFAIP6 was reported in the proximal tubular epithelial cells, a cell population that was demonstrated to have the potential to contribute to the pathogenesis of renal fibrosis.39 Similar to ACAN, TNFAIP6 also interacts with hyaluronic acid, which has been shown to be upregulated in keloid fibroblasts.27 Although Marneros et al20 did not identify mutations or disease-associated polymorphisms in the TNFAIP6 gene when screening genomic DNA of the affected and unaffected family members of the Japanese family used to establish the 2q23 keloid linkage.
TNFAIP6 Binding (interacts) of in proximal associated with fibrosis, dermal scarring, inflammation, disease and internal fibrosis
3) Confidence 0.32 Published 2010 Journal Eplasty Section Body Doc Link PMC2851107 Disease Relevance 1.16 Pain Relevance 0.14
TSG-6 (the secreted product of the tumor necrosis factor-stimulated gene 6) also binds to hyaluronan in the cumulus matrix [59-61].
TSG-6 Binding (binds) of associated with necrosis and cancer
4) Confidence 0.06 Published 2005 Journal Reprod Biol Endocrinol Section Body Doc Link PMC1266059 Disease Relevance 0.36 Pain Relevance 0
TSG-6 (the secreted product of the tumor necrosis factor-stimulated gene 6) also binds to hyaluronan in the cumulus matrix [59-61].
tumor necrosis factor-stimulated gene 6 Binding (binds) of associated with necrosis and cancer
5) Confidence 0.05 Published 2005 Journal Reprod Biol Endocrinol Section Body Doc Link PMC1266059 Disease Relevance 0.36 Pain Relevance 0

General Comments

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