INT123224

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Context Info
Confidence 0.70
First Reported 2005
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 12
Total Number 13
Disease Relevance 7.13
Pain Relevance 1.21

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (TNFAIP6) cell adhesion (TNFAIP6) cell-cell signaling (TNFAIP6)
Anatomy Link Frequency
connective tissues 4
margin 2
brain 2
internal 2
proximal 1
TNFAIP6 (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 34 100.00 Very High Very High Very High
rheumatoid arthritis 4 100.00 Very High Very High Very High
fibrosis 15 99.76 Very High Very High Very High
Pain 11 92.44 High High
cytokine 13 77.20 Quite High
Osteoarthritis 11 48.08 Quite Low
Sciatica 12 25.00 Low Low
Nicotine 48 5.00 Very Low Very Low Very Low
metalloproteinase 19 5.00 Very Low Very Low Very Low
backache 16 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Dermal Scarring 240 100.00 Very High Very High Very High
Disease 133 100.00 Very High Very High Very High
Cancer 46 100.00 Very High Very High Very High
INFLAMMATION 24 100.00 Very High Very High Very High
Necrosis 22 100.00 Very High Very High Very High
Rheumatoid Arthritis 4 100.00 Very High Very High Very High
Internal Fibrosis 10 99.76 Very High Very High Very High
Pain 11 92.44 High High
Targeted Disruption 2 88.40 High High
Keloid Scars 30 83.96 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
TNFAIP6 was shown to be involved in the inhibition of neutrophil migration, modulation of inflammation, and tissue remodeling.38 In individuals with renal fibrosis, increased expression of TNFAIP6 was reported in the proximal tubular epithelial cells, a cell population that was demonstrated to have the potential to contribute to the pathogenesis of renal fibrosis.39 Similar to ACAN, TNFAIP6 also interacts with hyaluronic acid, which has been shown to be upregulated in keloid fibroblasts.27 Although Marneros et al20 did not identify mutations or disease-associated polymorphisms in the TNFAIP6 gene when screening genomic DNA of the affected and unaffected family members of the Japanese family used to establish the 2q23 keloid linkage.
Gene_expression (expression) of TNFAIP6 in proximal associated with fibrosis, dermal scarring, inflammation, disease and internal fibrosis
1) Confidence 0.70 Published 2010 Journal Eplasty Section Body Doc Link PMC2851107 Disease Relevance 1.24 Pain Relevance 0.15
TNFalpha causes connective tissue cells in culture to synthesise a glycoprotein, TNFalpha-stimulated gene-6 (TSG-6).
Gene_expression (synthesise) of TNFalpha-stimulated gene-6 in connective tissue
2) Confidence 0.67 Published 2005 Journal Eur Spine J Section Abstract Doc Link 15549486 Disease Relevance 0.72 Pain Relevance 0.26
TSG-6 is found in inflammatory diseases of related connective tissues, such as articular cartilage in rheumatoid arthritis, but is not present in unaffected individuals.
Neg (not) Gene_expression (present) of TSG-6 in connective tissues associated with inflammation, rheumatoid arthritis and disease
3) Confidence 0.67 Published 2005 Journal Eur Spine J Section Abstract Doc Link 15549486 Disease Relevance 0.80 Pain Relevance 0.27
TSG-6 is found in inflammatory diseases of related connective tissues, such as articular cartilage in rheumatoid arthritis, but is not present in unaffected individuals.
Gene_expression (found) of TSG-6 in connective tissues associated with inflammation, rheumatoid arthritis and disease
4) Confidence 0.67 Published 2005 Journal Eur Spine J Section Abstract Doc Link 15549486 Disease Relevance 0.73 Pain Relevance 0.26
TNFalpha causes connective tissue cells in culture to synthesise a glycoprotein, TNFalpha-stimulated gene-6 (TSG-6).
Gene_expression (synthesise) of TSG-6 in connective tissue
5) Confidence 0.67 Published 2005 Journal Eur Spine J Section Abstract Doc Link 15549486 Disease Relevance 0.73 Pain Relevance 0.26
Ten of these 19 genes, including ACAN, ASPN, C5orf13, HIF1A, IGFBP7, INHBA, LGALS1, PTN, SERPINH1, and TNFAIP6 (Table 5), demonstrated a statistically significant difference for the gene expression levels between keloid margin and internal control skin.
Gene_expression (expression) of TNFAIP6 in internal associated with dermal scarring
6) Confidence 0.54 Published 2010 Journal Eplasty Section Body Doc Link PMC2851107 Disease Relevance 0.66 Pain Relevance 0
A statistically significant (P < .05) differential expression and a fold change of more than 2 were determined between keloid margin and internal control biopsy samples for 10 genes, including ACAN, ASPN, C5orf13, HIF1A, IGFBP7, INHBA, LGALS1, PTN, SERPINH1, and TNFAIP6 (Table 5).
Gene_expression (expression) of TNFAIP6 in internal associated with dermal scarring
7) Confidence 0.54 Published 2010 Journal Eplasty Section Body Doc Link PMC2851107 Disease Relevance 0.24 Pain Relevance 0
Ten of these 19 genes, including ACAN, ASPN, C5orf13, HIF1A, IGFBP7, INHBA, LGALS1, PTN, SERPINH1, and TNFAIP6 (Table 5), demonstrated a statistically significant difference for the gene expression levels between keloid margin and internal control skin.
Gene_expression (expression) of TNFAIP6 in margin associated with dermal scarring
8) Confidence 0.18 Published 2010 Journal Eplasty Section Body Doc Link PMC2851107 Disease Relevance 0.66 Pain Relevance 0
A statistically significant (P < .05) differential expression and a fold change of more than 2 were determined between keloid margin and internal control biopsy samples for 10 genes, including ACAN, ASPN, C5orf13, HIF1A, IGFBP7, INHBA, LGALS1, PTN, SERPINH1, and TNFAIP6 (Table 5).
Gene_expression (expression) of TNFAIP6 in margin associated with dermal scarring
9) Confidence 0.18 Published 2010 Journal Eplasty Section Body Doc Link PMC2851107 Disease Relevance 0.24 Pain Relevance 0
The additional genes, brain abundant, membrane attached signal protein 1 (BASP1), tenomodulin (TNMD), tumor necrosis factor, alpha-induced protein 6 (TNFAIP6), forkhead box F1 (FOXF1), forkhead box F2 (FOXF2) and aquaporin (AQP1) were included from the NP/AC comparisons (Table 6) because they had high differential expression levels but also had detectable levels of expression in the AF and were therefore of interest as transcriptional markers of an IVD cell.
Gene_expression (expression) of alpha-induced protein 6 in brain associated with necrosis and cancer
10) Confidence 0.17 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2875656 Disease Relevance 0.20 Pain Relevance 0
The additional genes, brain abundant, membrane attached signal protein 1 (BASP1), tenomodulin (TNMD), tumor necrosis factor, alpha-induced protein 6 (TNFAIP6), forkhead box F1 (FOXF1), forkhead box F2 (FOXF2) and aquaporin (AQP1) were included from the NP/AC comparisons (Table 6) because they had high differential expression levels but also had detectable levels of expression in the AF and were therefore of interest as transcriptional markers of an IVD cell.
Gene_expression (attached) of alpha-induced protein 6 in brain associated with necrosis and cancer
11) Confidence 0.17 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2875656 Disease Relevance 0.20 Pain Relevance 0
TSG-6 (the secreted product of the tumor necrosis factor-stimulated gene 6) also binds to hyaluronan in the cumulus matrix [59-61].
Gene_expression (product) of tumor necrosis factor-stimulated gene 6 associated with necrosis and cancer
12) Confidence 0.10 Published 2005 Journal Reprod Biol Endocrinol Section Body Doc Link PMC1266059 Disease Relevance 0.36 Pain Relevance 0
TSG-6 (the secreted product of the tumor necrosis factor-stimulated gene 6) also binds to hyaluronan in the cumulus matrix [59-61].
Gene_expression (product) of TSG-6 associated with necrosis and cancer
13) Confidence 0.09 Published 2005 Journal Reprod Biol Endocrinol Section Body Doc Link PMC1266059 Disease Relevance 0.35 Pain Relevance 0

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