INT12324

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Context Info
Confidence 0.70
First Reported 1992
Last Reported 2011
Negated 0
Speculated 2
Reported most in Abstract
Documents 26
Total Number 29
Disease Relevance 18.82
Pain Relevance 4.55

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (PRTN3) peptidase activity (PRTN3) plasma membrane (PRTN3)
enzyme binding (PRTN3)
Anatomy Link Frequency
neutrophil 3
Blood 2
respiratory tract 2
hemolymph 1
synovium 1
PRTN3 (Homo sapiens)
Pain Link Frequency Relevance Heat
rheumatoid arthritis 262 99.72 Very High Very High Very High
analgesia 3 99.44 Very High Very High Very High
cocaine 8 99.40 Very High Very High Very High
Inflammation 112 99.36 Very High Very High Very High
Morphine 2 97.92 Very High Very High Very High
Pain 16 92.40 High High
cytokine 51 91.04 High High
cva 32 89.08 High High
adenocard 10 88.96 High High
Inflammatory response 7 85.36 High High
Disease Link Frequency Relevance Heat
Increased Venous Pressure Under Development 51 99.96 Very High Very High Very High
Urological Neuroanatomy 14 99.84 Very High Very High Very High
Rheumatoid Arthritis 270 99.72 Very High Very High Very High
Wegener's Granulomatosis 2 99.62 Very High Very High Very High
Renal Disease 30 99.48 Very High Very High Very High
Syndrome 40 99.38 Very High Very High Very High
Granulomatous Inflammation 3 99.36 Very High Very High Very High
Microscopic Polyangiitis 50 98.96 Very High Very High Very High
Cocaine Dependence 4 98.92 Very High Very High Very High
INFLAMMATION 156 98.08 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Several clinical observations of cocaine abuse followed by Wegener granulomatosis suggest an active induction of a PR3-ANCA-positive vasculitis by cocaine.
Positive_regulation (induction) of PR3-ANCA-positive associated with wegener's granulomatosis, increased venous pressure under development and cocaine
1) Confidence 0.70 Published 2008 Journal Acta Derm. Venereol. Section Abstract Doc Link 19002345 Disease Relevance 1.18 Pain Relevance 0.24
The serological examination revealed markedly elevated anti-neutrophil cytoplasmic antibodies (ANCA) titres with positive reactions against proteinase-3, indicating Wegener's disease.
Positive_regulation (elevated) of ANCA in neutrophil associated with disease
2) Confidence 0.69 Published 2007 Journal Ned Tijdschr Geneeskd Section Abstract Doc Link 18019218 Disease Relevance 0.93 Pain Relevance 0.29
A significant elevation of PR-3 ANCA was also noted.
Positive_regulation (elevation) of PR-3
3) Confidence 0.67 Published 2007 Journal Rinsho Shinkeigaku Section Abstract Doc Link 17511274 Disease Relevance 1.06 Pain Relevance 0.27
Blood examination revealed an accelerated ESR, elevated CRP and slightly elevated c-ANCA.
Positive_regulation (elevated) of c-ANCA in Blood
4) Confidence 0.67 Published 1998 Journal Nihon Kokyuki Gakkai Zasshi Section Abstract Doc Link 9656673 Disease Relevance 0.81 Pain Relevance 0.09
An elevated cANCA and biopsy of SO confirmed Wegener's granulomatosis (WG).
Positive_regulation (elevated) of cANCA
5) Confidence 0.59 Published 2008 Journal Orbit Section Abstract Doc Link 18569830 Disease Relevance 0.35 Pain Relevance 0.09
This patient was negative for an initial c-ANCA test.
Positive_regulation (negative) of c-ANCA
6) Confidence 0.49 Published 2003 Journal Clin. Rheumatol. Section Abstract Doc Link 14677032 Disease Relevance 1.28 Pain Relevance 0.13
Pathogenesis of rheumatoid arthritis is likely to implicate anti-citrullinated protein/ peptide antibody(ACPA) and an immunodistortion including abnormal T cell subpopulation.
Spec (implicate) Positive_regulation (implicate) of ACPA in T cell associated with rheumatoid arthritis
7) Confidence 0.49 Published 2009 Journal Nippon Rinsho Section Abstract Doc Link 19280922 Disease Relevance 0.33 Pain Relevance 0.26
Laboratory tests indicated renal failure and proteinuria, as well as elevation of anti-neutrophilic cytoplasmic antibodies against proteinase 3 (PR3-ANCA).
Positive_regulation (elevation) of proteinase 3
8) Confidence 0.47 Published 2008 Journal Dtsch. Med. Wochenschr. Section Body Doc Link 18213550 Disease Relevance 0.17 Pain Relevance 0
He was diagnosed with anti-neutrophil cytoplasmic autoantibody (ANCA)-associated vasculitis (AAV) because the systemic examinations revealed only that he tested positive for anti-neutrophil cytoplasmic autoantibody (ANCA).
Spec (examinations) Positive_regulation (positive) of ANCA in neutrophil associated with increased venous pressure under development
9) Confidence 0.47 Published 2006 Journal J. Neurol. Sci. Section Abstract Doc Link 16274697 Disease Relevance 0.84 Pain Relevance 0.36
Laboratory tests indicated renal failure and proteinuria, as well as elevation of anti-neutrophilic cytoplasmic antibodies against proteinase 3 (PR3-ANCA).
Positive_regulation (elevation) of PR3
10) Confidence 0.45 Published 2008 Journal Dtsch. Med. Wochenschr. Section Body Doc Link 18213550 Disease Relevance 0.17 Pain Relevance 0
Biopsies of kidney and skin lesions showed a vasculitis, furthermore the C-ANCA-titer (anti-neutrophil cytoplasm antibodies) was strongly elevated which justified the diagnosis Wegener's granulomatosis (WG).
Positive_regulation (elevated) of C-ANCA in neutrophil associated with increased venous pressure under development
11) Confidence 0.45 Published 1992 Journal Tijdschr Kindergeneeskd Section Abstract Doc Link 1641847 Disease Relevance 0.76 Pain Relevance 0.09
Blood examination revealed an accelerated ESR, elevated CRP and slightly elevated c-ANCA.
Positive_regulation (elevated) of c-ANCA in Blood
12) Confidence 0.45 Published 1998 Journal Nihon Kokyuki Gakkai Zasshi Section Abstract Doc Link 9656673 Disease Relevance 0.80 Pain Relevance 0.09
The increase in sagittal range of motion on walking in the MBT sandal in our study could be attributed to the rounded sole design of the sole of the MBT footwear.
Positive_regulation (increase) of MBT
13) Confidence 0.43 Published 2011 Journal J Foot Ankle Res Section Body Doc Link PMC3024926 Disease Relevance 0 Pain Relevance 0
The observed increase in the range of motion at the ankle and subtalar joint complex in the MBT sandal could potentially be beneficial in certain patient groups, particularly in those where the decreased range of motion in these joints are putting strain on other parts of the musculoskeletal kinetic chain.
Positive_regulation (increase) of MBT in ankle associated with sprains and strains
14) Confidence 0.43 Published 2011 Journal J Foot Ankle Res Section Body Doc Link PMC3024926 Disease Relevance 0.09 Pain Relevance 0
Indirect immunofluorescence identifies two clinically important patterns of staining: cytoplasmic ANCA (cANCA) and perinuclear ANCA (pANCA).
Positive_regulation (perinuclear) of pANCA
15) Confidence 0.31 Published 2005 Journal Crit Care Section Body Doc Link PMC1065092 Disease Relevance 1.69 Pain Relevance 0.08
Other conditions may also produce a positive ANCA (up to 50% of CSS patients will give a positive result for PR-3 or MPO [22]), and other antigens can produce a similar staining pattern (especially the pANCA).
Positive_regulation (result) of PR-3 associated with syndrome and urological neuroanatomy
16) Confidence 0.29 Published 2005 Journal Crit Care Section Body Doc Link PMC1065092 Disease Relevance 1.14 Pain Relevance 0
This case suggests that sulphasalazine can induce PR3-ANCA-positive necrotizing glomerulonephritis.
Positive_regulation (induce) of PR3-ANCA-positive associated with renal disease
17) Confidence 0.26 Published 2009 Journal Clin. Nephrol. Section Abstract Doc Link 19203554 Disease Relevance 1.10 Pain Relevance 0.08
The only positive tests were an elevated cANCA in a titer of 1: 640 (Normal less than 1: 20) and anti-proteinase 3 antibodies of 118 units (Normal 0 – 20 units).
Positive_regulation (elevated) of cANCA
18) Confidence 0.21 Published 2008 Journal Cases J Section Body Doc Link PMC2621135 Disease Relevance 0.47 Pain Relevance 0.11
The proteinase responsible for this process was classified as a metal-dependent serine proteinase and was effectively inactivated by phenylmethylsulfonyl fluoride and ethylenediaminetetraacetic acid.
Positive_regulation (dependent) of proteinase
19) Confidence 0.18 Published 1998 Journal Regul. Pept. Section Abstract Doc Link 9537675 Disease Relevance 0.06 Pain Relevance 0.25
The proteinase responsible for this process was classified as a metal-dependent serine proteinase and was effectively inactivated by phenylmethylsulfonyl fluoride and ethylenediaminetetraacetic acid.
Positive_regulation (responsible) of proteinase
20) Confidence 0.18 Published 1998 Journal Regul. Pept. Section Abstract Doc Link 9537675 Disease Relevance 0.05 Pain Relevance 0.25

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