INT123251

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Context Info
Confidence 0.27
First Reported 2005
Last Reported 2006
Negated 0
Speculated 0
Reported most in Title
Documents 2
Total Number 2
Disease Relevance 0.36
Pain Relevance 0.67

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Chrna4) transport (Chrna4) plasma membrane (Chrna4)
neurological system process (Chrna4)
Anatomy Link Frequency
brain 2
forebrain 2
Chrna4 (Mus musculus)
Pain Link Frequency Relevance Heat
Nicotine 4 100.00 Very High Very High Very High
cINOD 2 100.00 Very High Very High Very High
Inflammation 1 100.00 Very High Very High Very High
Limbic system 1 99.08 Very High Very High Very High
Hippocampus 3 95.52 Very High Very High Very High
antagonist 1 87.68 High High
IPN 1 74.32 Quite High
addiction 1 51.68 Quite High
COX2 1 25.00 Low Low
Disease Link Frequency Relevance Heat
INFLAMMATION 1 100.00 Very High Very High Very High
Disease 1 93.28 High High
Dementia 1 92.04 High High
Aging 2 75.00 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Because the mouse is a useful model for age-related decline in nAChR expression in the basal forebrain and limbic system, we used immunohistochemistry to examine the influence of long-term (12-month) oral administration of nicotine and/or the cyclooxygenase-2 (COX-2) preferring non-steroidal anti-inflammatory drug (NSAID) NS398 on nAChR alpha4, alpha5, alpha7, and beta4 expression in the C57BL/6 mouse.
Regulation (influence) of Gene_expression (expression) of nAChR alpha4 in forebrain associated with inflammation, nicotine, cinod and limbic system
1) Confidence 0.27 Published 2005 Journal J. Neurobiol. Section Abstract Doc Link 15551346 Disease Relevance 0.36 Pain Relevance 0.57
Immunolabeling demonstrates the interdependence of mouse brain alpha4 and beta2 nicotinic acetylcholine receptor subunit expression.
Regulation (interdependence) of Gene_expression (expression) of alpha4 in brain
2) Confidence 0.20 Published 2006 Journal J. Comp. Neurol. Section Title Doc Link 17072836 Disease Relevance 0 Pain Relevance 0.10

General Comments

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