INT123253

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Context Info
Confidence 0.44
First Reported 2005
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 4
Total Number 4
Disease Relevance 1.31
Pain Relevance 1.99

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Chrna4) transport (Chrna4) plasma membrane (Chrna4)
neurological system process (Chrna4)
Chrna4 (Mus musculus)
Pain Link Frequency Relevance Heat
Nicotine 141 98.66 Very High Very High Very High
antagonist 5 95.48 Very High Very High Very High
Hippocampus 7 91.60 High High
cINOD 4 91.12 High High
Inflammation 2 86.00 High High
Spinal cord 1 83.56 Quite High
Glutamate 3 80.96 Quite High
noradrenaline 6 80.08 Quite High
Limbic system 2 78.40 Quite High
Nucleus accumbens 1 70.36 Quite High
Disease Link Frequency Relevance Heat
Stomach Cancer 1 99.44 Very High Very High Very High
Lifespan 1 96.76 Very High Very High Very High
Cancer 90 94.88 High High
Lung Cancer 24 86.52 High High
INFLAMMATION 2 86.00 High High
Adenocarcinoma 5 77.84 Quite High
Aging 4 75.00 Quite High
Disease 3 73.52 Quite High
Dementia 2 72.28 Quite High
Schizophrenia 5 57.92 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Administration of NS398 correlated with retention of nAChR alpha4 and to a lesser extent nAChR beta4, but not nAChR alpha5 or alpha7, but nicotine exhibited no similar effect.
Localization (retention) of nAChR alpha4 associated with nicotine
1) Confidence 0.44 Published 2005 Journal J. Neurobiol. Section Abstract Doc Link 15551346 Disease Relevance 0.31 Pain Relevance 0.58
Nicotine and NS398 co-administration abolished the NS398-related effect on nAChR alpha4 retention.
Localization (retention) of nAChR alpha4 associated with nicotine
2) Confidence 0.44 Published 2005 Journal J. Neurobiol. Section Abstract Doc Link 15551346 Disease Relevance 0.28 Pain Relevance 0.57
7 nAChR-mediated release of adrenaline, which in turn upregulates the expression of COX-2, PGE2 and VEGF, thereby facilitating the progression of these cancers [46], [47], [48].
Localization (release) of nAChR associated with cancer
3) Confidence 0.16 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2759510 Disease Relevance 0.57 Pain Relevance 0.59
7* nAChR or other receptors, then modulation of Type III Nrg1 signaling in sensory axons could contribute to adaptive physiological changes or to pathological changes in sensory transduction (Bermingham-McDonogh et al., 1997; Kerber et al., 2003).
Localization (modulation) of nAChR
4) Confidence 0.06 Published 2008 Journal The Journal of Cell Biology Section Body Doc Link PMC2364689 Disease Relevance 0.15 Pain Relevance 0.25

General Comments

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