INT123254

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Context Info
Confidence 0.27
First Reported 2005
Last Reported 2010
Negated 0
Speculated 1
Reported most in Abstract
Documents 3
Total Number 4
Disease Relevance 0.84
Pain Relevance 0.76

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Chrna4) transport (Chrna4) plasma membrane (Chrna4)
neurological system process (Chrna4)
Anatomy Link Frequency
forebrain 1
interpeduncular nucleus 1
Chrna4 (Mus musculus)
Pain Link Frequency Relevance Heat
Nicotine 4 100.00 Very High Very High Very High
cINOD 2 100.00 Very High Very High Very High
Inflammation 1 100.00 Very High Very High Very High
Limbic system 1 99.08 Very High Very High Very High
Hippocampus 31 92.48 High High
IPN 1 92.32 High High
agonist 4 89.32 High High
antagonist 5 85.92 High High
medulla 2 54.96 Quite High
addiction 1 39.36 Quite Low
Disease Link Frequency Relevance Heat
INFLAMMATION 1 100.00 Very High Very High Very High
Disease 1 93.28 High High
Targeted Disruption 54 92.88 High High
Dementia 1 92.04 High High
Aging 2 75.00 Quite High
Sprains And Strains 6 5.00 Very Low Very Low Very Low
Anxiety Disorder 2 5.00 Very Low Very Low Very Low
Attention Deficit Hyperactivity Disorder 2 5.00 Very Low Very Low Very Low
Urological Neuroanatomy 2 5.00 Very Low Very Low Very Low
Infection 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Because the mouse is a useful model for age-related decline in nAChR expression in the basal forebrain and limbic system, we used immunohistochemistry to examine the influence of long-term (12-month) oral administration of nicotine and/or the cyclooxygenase-2 (COX-2) preferring non-steroidal anti-inflammatory drug (NSAID) NS398 on nAChR alpha4, alpha5, alpha7, and beta4 expression in the C57BL/6 mouse.
Regulation (influence) of nAChR alpha4 in forebrain associated with inflammation, nicotine, cinod and limbic system
1) Confidence 0.27 Published 2005 Journal J. Neurobiol. Section Abstract Doc Link 15551346 Disease Relevance 0.36 Pain Relevance 0.48
To explore further the role of nAChR subunit function in learning and memory, we assessed the performance of ?
Regulation (role) of nAChR
2) Confidence 0.12 Published 2010 Journal Frontiers in Behavioral Neuroscience Section Body Doc Link PMC2958052 Disease Relevance 0.09 Pain Relevance 0.19
The present study used genetically modified mice to investigate the effects of selective nAChR subunit deletion on delay and trace eyeblink classical conditioning. ?
Spec (investigate) Regulation (effects) of nAChR
3) Confidence 0.11 Published 2010 Journal Frontiers in Behavioral Neuroscience Section Abstract Doc Link PMC2958052 Disease Relevance 0.39 Pain Relevance 0
Immunolabeling autoradiography was used to map and quantitate the effects of beta2 and alpha4 subunit-null mutations on their putative partner subunits' protein expression. [(125)I]mAb 299 labeling was nearly eliminated in beta2(-/-) sections, although dorsal interpeduncular nucleus (IPN) retained a faint signal.
Regulation (effects) of alpha4 in interpeduncular nucleus associated with ipn
4) Confidence 0.09 Published 2006 Journal J. Comp. Neurol. Section Abstract Doc Link 17072836 Disease Relevance 0 Pain Relevance 0.09

General Comments

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