INT12327

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Context Info
Confidence 0.03
First Reported 1992
Last Reported 1992
Negated 0
Speculated 0
Reported most in Abstract
Documents 1
Total Number 1
Disease Relevance 0.73
Pain Relevance 1.57

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytoskeletal protein binding (Plec) plasma membrane (Plec) cytoskeleton (Plec)
cytoplasm (Plec)
Igh-Dex (Mus musculus)
Plec (Mus musculus)
Pain Link Frequency Relevance Heat
dexamethasone 9 100.00 Very High Very High Very High
Paracetamol 16 98.64 Very High Very High Very High
Disease Link Frequency Relevance Heat
Hepatotoxicity 9 96.76 Very High Very High Very High
Injury 1 68.88 Quite High
Toxicity 1 59.12 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Thus, whereas PCN has been shown to markedly decrease the hepatotoxicity of AA in hamsters, apparently by decreasing the isoform of P450 responsible for activating AA to N-acetyl-p-benzoquinoneimine, this does not occur in mice after induction with either PCN or DEX.
DEX Positive_regulation (induction) of PCN associated with paracetamol, hepatotoxicity and dexamethasone
1) Confidence 0.03 Published 1992 Journal Toxicol. Appl. Pharmacol. Section Abstract Doc Link 1641853 Disease Relevance 0.73 Pain Relevance 1.57

General Comments

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