INT123284

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Context Info
Confidence 0.46
First Reported 2004
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 3
Total Number 3
Disease Relevance 2.34
Pain Relevance 1.22

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (Cyp2e1) oxidoreductase activity (Cyp2e1) endoplasmic reticulum (Cyp2e1)
enzyme binding (Cyp2e1)
Anatomy Link Frequency
liver 2
Cyp2e1 (Mus musculus)
Pain Link Frequency Relevance Heat
Paracetamol 16 98.62 Very High Very High Very High
Analgesic 1 52.64 Quite High
tolerance 2 52.04 Quite High
alcohol 9 47.00 Quite Low
fibrosis 12 25.00 Low Low
Inflammation 16 5.00 Very Low Very Low Very Low
agonist 11 5.00 Very Low Very Low Very Low
Bile 5 5.00 Very Low Very Low Very Low
chemokine 4 5.00 Very Low Very Low Very Low
Kinase C 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Diabetes Mellitus 18 99.86 Very High Very High Very High
Fatty Liver 67 99.80 Very High Very High Very High
Obesity 14 99.60 Very High Very High Very High
Stress 15 96.64 Very High Very High Very High
Nash(non-alcoholic Steatohepatitis) 32 96.36 Very High Very High Very High
Injury 9 90.08 High High
Hepatotoxicity 3 84.08 Quite High
Alcoholic Liver Diseases 2 83.96 Quite High
Apoptosis 7 79.92 Quite High
Body Weight 2 72.96 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Besides, APAP exposure significantly reduced mitochondrial membrane potential and induced up-regulation of CYP2E1 in renal tissues although JNK did not play any significant role in this APAP-induced renal pathophysiology.
Positive_regulation (induced) of Positive_regulation (up-regulation) of CYP2E1 associated with paracetamol
1) Confidence 0.46 Published 2010 Journal Toxicology Section Abstract Doc Link 20067817 Disease Relevance 0.58 Pain Relevance 1.13
Excess of these physiological substrates (such as seen in obesity and diabetes) also leads to CYP2E1 induction and nonalcoholic fatty liver disease (NAFLD), which includes nonalcoholic fatty liver and nonalcoholic steatohepatitis (NASH), with pathological lesions similar to those observed in alcoholic steatohepatitis.
Positive_regulation (leads) of Positive_regulation (induction) of CYP2E1 in liver associated with fatty liver, nash(non-alcoholic steatohepatitis), diabetes mellitus and obesity
2) Confidence 0.44 Published 2004 Journal Drug Metab. Rev. Section Abstract Doc Link 15554233 Disease Relevance 1.51 Pain Relevance 0.09
The induction of CYP2E1 by many potentially toxic/carcinogenic substrates such as ethanol, benzene, and haloalkanes and their metabolisms promote ROS production [6].
Positive_regulation (promote) of Positive_regulation (induction) of CYP2E1
3) Confidence 0.42 Published 2009 Journal PPAR Research Section Body Doc Link PMC2840373 Disease Relevance 0.25 Pain Relevance 0

General Comments

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