INT123305

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Context Info
Confidence 0.55
First Reported 2004
Last Reported 2008
Negated 0
Speculated 2
Reported most in Body
Documents 2
Total Number 10
Disease Relevance 2.55
Pain Relevance 0.53

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mRNA processing (Smn1) nucleolus (Smn1) RNA binding (Smn1)
nucleus (Smn1) cytoplasm (Smn1)
Anatomy Link Frequency
spinal cord 2
fibroblasts 2
Smn1 (Mus musculus)
Pain Link Frequency Relevance Heat
Spinal cord 36 97.22 Very High Very High Very High
cINOD 3 96.48 Very High Very High Very High
Central nervous system 18 75.40 Quite High
Intracerebroventricular 18 71.08 Quite High
fibrosis 9 45.28 Quite Low
anesthesia 9 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Spinal Muscular Atrophy 289 99.96 Very High Very High Very High
INFLAMMATION 1 95.04 Very High Very High Very High
Neurodegenerative Disease 10 85.40 High High
Targeted Disruption 9 80.80 Quite High
Disease 54 80.28 Quite High
Death 9 74.52 Quite High
Frailty 9 50.52 Quite High
Epidermolysis Bullosa Simplex 9 49.56 Quite Low
Coagulation Disorder 9 47.24 Quite Low
Immunodeficiency 9 46.76 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
This single vector platform allows for the production of two individual RNAs that target distinct aspects of SMN pre-mRNA, leading to enhanced full-length SMN expression (Figure 1A).
Positive_regulation (leading) of Gene_expression (expression) of SMN
1) Confidence 0.55 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2565107 Disease Relevance 0.13 Pain Relevance 0
This single vector platform allows for the production of two individual RNAs that target distinct aspects of SMN pre-mRNA, leading to enhanced full-length SMN expression (Figure 1A).
Positive_regulation (enhanced) of Gene_expression (expression) of SMN
2) Confidence 0.55 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2565107 Disease Relevance 0.13 Pain Relevance 0
Therefore, we initially examined SMN2 trans-splicing with the goal of devising strategies to enhance trans-splicing efficiency in vivo.
Spec (examined) Positive_regulation (examined) of Spec (examined) Gene_expression (examined) of SMN2
3) Confidence 0.46 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2565107 Disease Relevance 0.31 Pain Relevance 0.07
In addition to the identification and development of small molecules that stimulate full-length SMN2 expression, RNA modalities such as antisense oligonucleotides (ASO), TOES/bifunctional RNAs and trans-splicing RNAs have shown promise in SMA cell-based models [14]–[20].
Positive_regulation (stimulate) of Gene_expression (expression) of SMN2 associated with spinal muscular atrophy
4) Confidence 0.43 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2565107 Disease Relevance 0.70 Pain Relevance 0
The endogenous pMU2-tsRNAEX4 mediated trans-SMN product was amplified using primer Exon 3+126 (Fwd 5?
Positive_regulation (mediated) of Gene_expression (product) of trans-SMN
5) Confidence 0.40 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2565107 Disease Relevance 0 Pain Relevance 0
-actin) and between experiments SMN levels is normalized to GM3813 values (triplicate mean set to 1).
Positive_regulation (experiments) of Gene_expression (levels) of SMN
6) Confidence 0.40 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2565107 Disease Relevance 0 Pain Relevance 0
To determine whether the cell-based analysis of pMU3 translated into comparable results in vivo, SMN proteins were examined in a previously described mouse model of SMA, referred to as SMN?
Positive_regulation (referred) of Gene_expression (referred) of SMN associated with spinal muscular atrophy
7) Confidence 0.40 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2565107 Disease Relevance 0.38 Pain Relevance 0.06
Western blots of disassociated whole spinal cord extracts from five individual pMU3-treated SMA pups were examined and shown to contain significantly elevated levels of SMN protein. pMU3-induced levels of SMN were significantly higher than untreated SMA mice and were comparable to SMN levels detected in homogenates from unaffected heterozygotes (Figure 7B).
Positive_regulation (induced) of Gene_expression (levels) of SMN in spinal cord associated with spinal muscular atrophy and spinal cord
8) Confidence 0.40 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2565107 Disease Relevance 0.52 Pain Relevance 0.13
To determine whether pMU3 increased SMN gems, fibroblasts transfected with pMU3 plus a panel of negative controls were examined by indirect immunofluorescence.
Spec (whether) Positive_regulation (increased) of Gene_expression (gems) of SMN in fibroblasts
9) Confidence 0.40 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2565107 Disease Relevance 0.09 Pain Relevance 0
We performed a high-throughput screen of approximately 47,000 compounds to identify those that increase production of an SMN2-luciferase reporter protein, but not an SMN1-luciferase reporter protein.
Positive_regulation (increase) of Gene_expression (production) of SMN1
10) Confidence 0.21 Published 2004 Journal Chem. Biol. Section Abstract Doc Link 15555999 Disease Relevance 0.27 Pain Relevance 0.27

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