INT12333

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Context Info
Confidence 0.62
First Reported 1992
Last Reported 2010
Negated 1
Speculated 3
Reported most in Abstract
Documents 18
Total Number 21
Disease Relevance 2.25
Pain Relevance 6.74

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Anatomy Link Frequency
blood 1
liver 1
CYP3A (Homo sapiens)
Pain Link Frequency Relevance Heat
rapifen 23 100.00 Very High Very High Very High
Buprenorphine 18 100.00 Very High Very High Very High
Versed 9 100.00 Very High Very High Very High
fluoxetine 8 100.00 Very High Very High Very High
Oxycodone 14 99.84 Very High Very High Very High
ergotamine 8 99.80 Very High Very High Very High
methadone 6 98.92 Very High Very High Very High
Analgesic 3 98.20 Very High Very High Very High
MU agonist 2 97.12 Very High Very High Very High
ketamine 1 95.96 Very High Very High Very High
Disease Link Frequency Relevance Heat
Aging 9 97.64 Very High Very High Very High
Newborn Jaundice 1 96.16 Very High Very High Very High
Body Weight 8 95.40 Very High Very High Very High
Nicotine Addiction 3 93.12 High High
Hyperbilirubinemia 21 90.00 High High
Cancer Pain 2 86.72 High High
Acquired Immune Deficiency Syndrome Or Hiv Infection 66 86.40 High High
Miosis 2 86.28 High High
Cluster Headache 10 71.28 Quite High
Chronic Renal Failure 2 64.48 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
However, CYP3A activity was unaffected by age over the range of 27-83 years, suggesting that the aging-related alteration in the clearance of CYP3A substrates is secondary to changes in liver blood flow, size, or drug binding and distribution with aging.
Neg (unaffected) Regulation (unaffected) of CYP3A in blood associated with aging
1) Confidence 0.62 Published 1992 Journal Biochem. Pharmacol. Section Abstract Doc Link 1642641 Disease Relevance 0.44 Pain Relevance 0.10
Ritonavir effects on CYP3A and P-glycoprotein activities.
Regulation (effects) of CYP3A
2) Confidence 0.60 Published 2008 Journal Clin. Pharmacol. Ther. Section Title Doc Link 19238656 Disease Relevance 0.09 Pain Relevance 0.48
This study determined the effects of parecoxib on the pharmacokinetics and pharmacodynamics of the CYP3A substrates fentanyl and alfentanil compared with the CYP3A inhibitor troleandomycin.
Spec (determined) Regulation (effects) of CYP3A associated with rapifen
3) Confidence 0.45 Published 2003 Journal Anesthesiology Section Abstract Doc Link 12657846 Disease Relevance 0 Pain Relevance 0.38
This investigation examined the influence of hepatic and intestinal CYP3A activity on the disposition and clinical effects of OTF.
Spec (examined) Regulation (influence) of CYP3A
4) Confidence 0.44 Published 2004 Journal Anesthesiology Section Abstract Doc Link 15329598 Disease Relevance 0.09 Pain Relevance 0.17
Ritonavir is minimally affected by other CYP3A inhibitors, including ketoconazole.
Regulation (affected) of CYP3A
5) Confidence 0.44 Published 1998 Journal Clin Pharmacokinet Section Abstract Doc Link 9812178 Disease Relevance 0.23 Pain Relevance 0.14
Effects of the CYP3A inhibitors troleandomycin and ketoconazole were also determined.
Regulation (Effects) of CYP3A
6) Confidence 0.30 Published 2005 Journal Drug Metab. Dispos. Section Abstract Doc Link 15557344 Disease Relevance 0 Pain Relevance 0.39
To determine whether these metabolic effects are due to changes in CYP3A, the effects of age and gender on CYP3A activity were examined.
Spec (whether) Regulation (changes) of CYP3A
7) Confidence 0.27 Published 1992 Journal Biochem. Pharmacol. Section Abstract Doc Link 1642641 Disease Relevance 0.21 Pain Relevance 0.14
Effect of age and gender on the activity of human hepatic CYP3A.
Regulation (Effect) of CYP3A
8) Confidence 0.27 Published 1992 Journal Biochem. Pharmacol. Section Title Doc Link 1642641 Disease Relevance 0.21 Pain Relevance 0.13
Effect of buprenorphine on CYP3A activity in rat and human liver microsomes.
Regulation (Effect) of CYP3A in liver associated with buprenorphine
9) Confidence 0.27 Published 2000 Journal Life Sci. Section Title Doc Link 10755464 Disease Relevance 0.06 Pain Relevance 1.07
Since buprenorphine and many benzodiazepines are CYP3A substrates, the effect of buprenorphine on CYP3A activity was examined in order to assess the likelihood of a pharmacokinetic interaction.
Regulation (effect) of CYP3A associated with buprenorphine
10) Confidence 0.27 Published 2000 Journal Life Sci. Section Abstract Doc Link 10755464 Disease Relevance 0 Pain Relevance 0.98
Effect of fluoxetine, norfluoxetine, sertraline and desmethyl sertraline on human CYP3A catalyzed 1'-hydroxy midazolam formation in vitro.
Regulation (Effect) of CYP3A associated with versed and fluoxetine
11) Confidence 0.24 Published 1995 Journal J. Pharmacol. Exp. Ther. Section Title Doc Link 8531073 Disease Relevance 0 Pain Relevance 0.62
DISCUSSION: Peak fentanyl concentrations and clinical effects after OTF were minimally affected by altering both intestinal and hepatic CYP3A activity, whereas fentanyl metabolism, elimination, and duration of effects were significantly affected; selective intestinal CYP3A inhibition had minimal effects.
Regulation (altering) of CYP3A
12) Confidence 0.23 Published 2004 Journal Anesthesiology Section Body Doc Link 15329598 Disease Relevance 0 Pain Relevance 0
Nonetheless, there is good evidence from animal studies supporting that CYP3As are the major enzymes responsible for ergotamine metabolism (17).
Regulation (responsible) of CYP3As associated with ergotamine
13) Confidence 0.23 Published 2008 Journal AAPS J Section Body Doc Link PMC2751378 Disease Relevance 0.24 Pain Relevance 1.04
The effects of CYP2D6 and CYP3A activities on the pharmacokinetics of immediate release oxycodone.
Regulation (effects) of CYP3A associated with oxycodone
14) Confidence 0.21 Published 2010 Journal Br. J. Pharmacol. Section Title Doc Link 20590587 Disease Relevance 0 Pain Relevance 0.28
CONCLUSIONS AND IMPLICATIONS: The modulation of CYP2D6 and CYP3A activities had clear effects on oxycodone pharmacodynamics and these effects were dependent on CYP2D6 genetic polymorphism.


Regulation (modulation) of CYP3A
15) Confidence 0.19 Published 2010 Journal Br. J. Pharmacol. Section Body Doc Link 20590588 Disease Relevance 0 Pain Relevance 0
In contrast with our data, there is some evidence in the literature for regulation of fish CYP3As by estrogens, however, generally in an inhibitory, rather than a stimulatory, manner (e.g., Arukwe et al. 1997; Buhler et al. 2000).
Regulation (regulation) of CYP3As
16) Confidence 0.18 Published 2007 Journal Environ Health Perspect Section Body Doc Link PMC2137123 Disease Relevance 0 Pain Relevance 0
Genetic polymorphisms and drug interactions modulating CYP2D6 and CYP3A activities have a major effect on oxycodone analgesic efficacy and safety.
Regulation (modulating) of CYP3A associated with oxycodone and analgesic
17) Confidence 0.14 Published 2010 Journal Br. J. Pharmacol. Section Title Doc Link 20590588 Disease Relevance 0 Pain Relevance 0.46
ATV is a substrate and inhibitor of CYP3A (Ki value of 0.84 to 1.0 ?
Regulation (value) of CYP3A
18) Confidence 0.13 Published 2009 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2697529 Disease Relevance 0.69 Pain Relevance 0
The participation of CYP3A is an important discovery since medetomidine is used as a premedicant in combination with fentanyl, ketamine and/or midazolam.
Regulation (participation) of CYP3A associated with versed and ketamine
19) Confidence 0.13 Published 2010 Journal Biomed. Chromatogr. Section Abstract Doc Link 20020418 Disease Relevance 0 Pain Relevance 0.10
The effects of CYP2D6 and/or CYP3A activity modulation on the pharmacokinetics of oxycodone remains poorly explored.
Regulation (modulation) of CYP3A associated with oxycodone
20) Confidence 0.13 Published 2010 Journal Br. J. Pharmacol. Section Abstract Doc Link 20590587 Disease Relevance 0 Pain Relevance 0.27

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