INT123338

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Context Info
Confidence 0.26
First Reported 2004
Last Reported 2010
Negated 1
Speculated 1
Reported most in Body
Documents 4
Total Number 5
Disease Relevance 1.52
Pain Relevance 0.47

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

unfolded protein binding (HSP90B2P) protein folding (HSP90B2P) response to stress (HSP90B2P)
Anatomy Link Frequency
muscle 1
skeletal muscle tissue 1
corneas 1
HSP90B2P (Homo sapiens)
Pain Link Frequency Relevance Heat
cINOD 5 94.08 High High
tolerance 26 71.92 Quite High
Pain 3 25.00 Low Low
Inflammation 4 5.00 Very Low Very Low Very Low
anesthesia 3 5.00 Very Low Very Low Very Low
ketamine 2 5.00 Very Low Very Low Very Low
imagery 2 5.00 Very Low Very Low Very Low
corticosteroid 1 5.00 Very Low Very Low Very Low
Spinal cord 1 5.00 Very Low Very Low Very Low
cytokine 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Shock 23 100.00 Very High Very High Very High
INFLAMMATION 6 93.52 High High
Stress 31 90.32 High High
Corneal Neovascularization 1 76.36 Quite High
Hyphema 1 74.32 Quite High
Apoptosis 3 72.80 Quite High
Impaired Glucose Tolerance 22 71.92 Quite High
Cataract 20 69.20 Quite High
Targeted Disruption 15 68.12 Quite High
Disease 1 65.68 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Both inhibitors up-regulated the hsp promoter at 37 degrees C through the activation of heat shock factors, and increased cellular levels of hsps in mammalian cells, although the degree of the expression of hsps and thermotolerance of cells differed depending on the drugs.
Regulation (regulated) of hsp associated with shock
1) Confidence 0.26 Published 2004 Journal Eur. J. Biochem. Section Abstract Doc Link 15560796 Disease Relevance 0.58 Pain Relevance 0.41
Cellular regulation and localization of heat shock protein (HSP) 27, alpha B-crystallin, and HSP70 were analyzed by immunohistochemistry, ELISA technique, and Western blotting.
Regulation (regulation) of HSP associated with shock
2) Confidence 0.26 Published 2007 Journal Am. J. Physiol. Regul. Integr. Comp. Physiol. Section Abstract Doc Link 17522120 Disease Relevance 0.26 Pain Relevance 0
We did not observe any changes in Hsp 27 or 90 in the corneas or lenses.
Neg (not) Regulation (changes) of Hsp in corneas
3) Confidence 0.06 Published 2004 Journal Journal of Korean Medical Science Section Body Doc Link PMC2816848 Disease Relevance 0.46 Pain Relevance 0
This is the first study to investigate the HSP responses in human skeletal muscle tissue during a long-term exercise-diet intervention.
Spec (investigate) Regulation (responses) of HSP in skeletal muscle tissue
4) Confidence 0.01 Published 2008 Journal BMC Endocr Disord Section Body Doc Link PMC2330145 Disease Relevance 0.22 Pain Relevance 0.06
Normalization of immuno-positive myosin bands to the Hsp 70 loading control in three independent experiments showed that in wild-type myotubes MyHCemb levels peaked at day 3 and then fell as expression of other isoforms increased (Fig. 6A and B); this pattern of expression has been described in both mouse and human muscle cultures [14], [35].
Regulation (ing con) of Hsp in muscle
5) Confidence 0.01 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2844429 Disease Relevance 0 Pain Relevance 0

General Comments

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