INT12334

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Context Info
Confidence 0.70
First Reported 1992
Last Reported 2010
Negated 1
Speculated 2
Reported most in Abstract
Documents 34
Total Number 36
Disease Relevance 6.77
Pain Relevance 7.85

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
plasma 4
liver 3
hepatocytes 2
CYP3A (Homo sapiens)
Pain Link Frequency Relevance Heat
antiepileptic Drug 26 99.86 Very High Very High Very High
carbamazepine 39 99.82 Very High Very High Very High
fluoxetine 14 99.70 Very High Very High Very High
dexamethasone 180 99.54 Very High Very High Very High
Versed 14 99.46 Very High Very High Very High
methadone 43 99.28 Very High Very High Very High
antidepressant 4 96.16 Very High Very High Very High
diclofenac 35 96.08 Very High Very High Very High
tricyclic antidepressant 7 95.20 Very High Very High Very High
Potency 12 91.36 High High
Disease Link Frequency Relevance Heat
Acquired Immune Deficiency Syndrome Or Hiv Infection 149 99.32 Very High Very High Very High
Vomiting 86 97.64 Very High Very High Very High
Body Weight 11 97.44 Very High Very High Very High
Hepatotoxicity 7 95.38 Very High Very High Very High
Nicotine Addiction 47 95.16 Very High Very High Very High
Infection 43 93.76 High High
Immunodeficiency 3 92.88 High High
Repression 2 92.12 High High
Substance Withdrawal Syndrome 2 91.12 High High
Adverse Drug Reaction 4 90.80 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Large interindividual differences and a small female-specific increase in CYP3A activity were obtained.
Positive_regulation (increase) of CYP3A
1) Confidence 0.70 Published 1992 Journal Biochem. Pharmacol. Section Abstract Doc Link 1642641 Disease Relevance 0.35 Pain Relevance 0.10
Ritonavir diminishes methadone plasma concentrations, an effect attributed to CYP3A induction, but the actual mechanisms are unknown.
Positive_regulation (induction) of CYP3A in plasma associated with methadone
2) Confidence 0.70 Published 2008 Journal Clin. Pharmacol. Ther. Section Abstract Doc Link 19238655 Disease Relevance 0.18 Pain Relevance 0.53
Ritonavir diminishes methadone plasma concentrations, an effect attributed to CYP3A induction, but the actual mechanisms are unknown.
Positive_regulation (induction) of CYP3A in plasma associated with methadone
3) Confidence 0.68 Published 2008 Journal Clin. Pharmacol. Ther. Section Abstract Doc Link 19238656 Disease Relevance 0.08 Pain Relevance 0.39
Steady-state compared with acute ritonavir caused mild apparent induction of P-gp and hepatic CYP3A, but net inhibition still predominated.
Positive_regulation (induction) of CYP3A
4) Confidence 0.68 Published 2008 Journal Clin. Pharmacol. Ther. Section Abstract Doc Link 19238656 Disease Relevance 0.07 Pain Relevance 0.43
Rifampin induction of CYP3A, a known effect of rifampin in vivo, was also reproduced in primary human hepatocytes.
Positive_regulation (induction) of CYP3A in hepatocytes
5) Confidence 0.66 Published 1997 Journal Cell Biol. Toxicol. Section Abstract Doc Link 9298257 Disease Relevance 0 Pain Relevance 0.15
Because ritonavir can induce CYP3A, it can decrease methadone plasma levels.
Positive_regulation (induce) of CYP3A in plasma associated with methadone
6) Confidence 0.65 Published 2000 Journal Pharmacotherapy Section Abstract Doc Link 10641980 Disease Relevance 0.47 Pain Relevance 0.46
This investigation tested the hypothesis that CYP3A induction (or inhibition) would increase (or decrease) methadone metabolism and clearance in humans.
Positive_regulation (induction) of CYP3A associated with methadone
7) Confidence 0.65 Published 2004 Journal Clin. Pharmacol. Ther. Section Abstract Doc Link 15371986 Disease Relevance 0.09 Pain Relevance 0.73
Dexamethasone is also metabolized by CYP3A and is a weak inducer of CYP3A after prolonged exposure or repeat-dose administration [7, 18].
Positive_regulation (inducer) of CYP3A associated with dexamethasone
8) Confidence 0.52 Published 2009 Journal Support Care Cancer Section Body Doc Link PMC2726912 Disease Relevance 0.38 Pain Relevance 0.51
By co-treatment with specific inhibitors for cytochrome P450 (CYP) 2C and CYP3A - the major phase I enzymes involved in liver xenobiotic metabolism - we could confirm the prominent role of CYP3A in the bioactivation of troglitazone as well as the role of CYP3A and CYP2C in the activation of diclofenac.
Positive_regulation (role) of CYP3A in liver associated with diclofenac
9) Confidence 0.50 Published 2009 Journal Chem. Biol. Interact. Section Abstract Doc Link 19022234 Disease Relevance 0.50 Pain Relevance 0.34
Paradoxically, however, CYP3A induction decreased and inhibition increased LAAM active metabolite concentrations and clinical effects.
Positive_regulation (induction) of CYP3A
10) Confidence 0.47 Published 2005 Journal Clin Pharmacokinet Section Body Doc Link 15966756 Disease Relevance 0 Pain Relevance 0
This investigation tested the hypothesis that CYP3A induction (or inhibition) would increase (or decrease) LAAM metabolism and bioactivation and, thus, clinical effects.
Positive_regulation (induction) of CYP3A
11) Confidence 0.47 Published 2005 Journal Clin Pharmacokinet Section Abstract Doc Link 15966756 Disease Relevance 0.09 Pain Relevance 0.25
Subjects received oral LAAM (0.25 mg/kg) after CYP3A induction (rifampicin [rifampin]), inhibition (troleandomycin) or nothing (controls).
Positive_regulation (induction) of CYP3A
12) Confidence 0.47 Published 2005 Journal Clin Pharmacokinet Section Body Doc Link 15966756 Disease Relevance 0 Pain Relevance 0
They received OTF (10 microg/kg) after hepatic/intestinal CYP3A induction by rifampin, hepatic/intestinal CYP3A inhibition by troleandomycin, selective intestinal CYP3A inhibition by grapefruit juice, or nothing (control).
Positive_regulation (induction) of CYP3A
13) Confidence 0.46 Published 2004 Journal Anesthesiology Section Body Doc Link 15329598 Disease Relevance 0 Pain Relevance 0
Coadministration of lopinavir/ritonavir is contraindicated with certain drugs (i.e. flecainide, propafenone, astemizole, terfenadine, ergot derivatives, cisapride, pimozide, midazolam and triazolam) that are highly dependent on CYP3A or CYP2D6 for clearance and for which elevated plasma concentrations are associated with serious and/or life-threatening events.
Positive_regulation (dependent) of CYP3A in plasma associated with versed
14) Confidence 0.45 Published 2003 Journal Drugs Section Abstract Doc Link 12662125 Disease Relevance 0.21 Pain Relevance 0.05
Persons homozygous for the PXR A7635G (rs2276707) G-allele and persons carrying at least one PXR C8055T (rs6785049) T-allele have significant higher levels of intestinal CYP3A level following in vivo treatment with the inducer rifampin than the homozygous wildtype carriers [35].
Positive_regulation (levels) of CYP3A
15) Confidence 0.42 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2949803 Disease Relevance 1.00 Pain Relevance 0.08
Comparative studies with human liver microsomes suggested the possible involvement of CYP3A enzymes in the intestinal catalysis of testosterone 6 beta-hydroxylation similar to those observed with human hepatic CYP3A.
Spec (possible) Positive_regulation (involvement) of CYP3A in liver
16) Confidence 0.42 Published 1996 Journal Drug Metab. Dispos. Section Abstract Doc Link 8781778 Disease Relevance 0 Pain Relevance 0.08
CYP2E, CYP2C, CYP2B6 and CYP3A (but not CYP1A, glucuronyl S-transferase or S-transferase) were inducible in M1.
Positive_regulation (inducible) of CYP3A
17) Confidence 0.39 Published 2004 Journal Xenobiotica Section Abstract Doc Link 15204697 Disease Relevance 0 Pain Relevance 0.14
They received intravenous (IV) midazolam (to assess CYP3A4 activity) and then simultaneous oral deuterium-labeled and IV unlabeled methadone after pretreatment with rifampin (INN, rifampicin) (hepatic/intestinal CYP3A induction), troleandomycin (hepatic/intestinal CYP3A inhibition), grapefruit juice (selective intestinal CYP3A inhibition), or nothing.
Positive_regulation (induction) of CYP3A
18) Confidence 0.38 Published 2004 Journal Clin. Pharmacol. Ther. Section Body Doc Link 15371986 Disease Relevance 0 Pain Relevance 0
As mentioned earlier, rifampicin is possibly associated with plural molecular species of P450 (several isozymes), but mainly, a large increase in the CYP3A content often becomes a problem, while phenobarbital, carbamazepine and phenytoin, antiepileptic drugs, also induce CYP3A [32].
Positive_regulation (increase) of CYP3A associated with antiepileptic drug and carbamazepine
19) Confidence 0.36 Published 2008 Journal Nutr Metab (Lond) Section Body Doc Link PMC2584094 Disease Relevance 0 Pain Relevance 0.20
Because of potential hepatotoxicity, nevirapine should not be used in post-pubertal females with CD4 > 250 or males with CD4 > 400, unless benefits of therapy outweigh the risks.30,31 Nevirapine also has the potential for numerous drug interactions as it acts as an inducer of hepatic cytochrome p450 enzymes including CYP3A and 2B6.
Positive_regulation (inducer) of CYP3A associated with hepatotoxicity
20) Confidence 0.36 Published 2009 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2701488 Disease Relevance 0.62 Pain Relevance 0

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