INT123382

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Context Info
Confidence 0.69
First Reported 2004
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 12
Total Number 12
Disease Relevance 4.62
Pain Relevance 8.62

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Cxcr2) plasma membrane (Cxcr2) intracellular (Cxcr2)
signal transducer activity (Cxcr2)
Anatomy Link Frequency
neurons 6
macrophage 2
leukocytes 1
IB4 1
Cxcr2 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Opioid 33 100.00 Very High Very High Very High
chemokine 114 99.78 Very High Very High Very High
Inflammation 141 98.96 Very High Very High Very High
Central nervous system 9 98.60 Very High Very High Very High
Pain 125 98.12 Very High Very High Very High
Action potential 138 97.96 Very High Very High Very High
dorsal root ganglion 31 97.44 Very High Very High Very High
cytokine 64 96.32 Very High Very High Very High
antinociception 18 96.24 Very High Very High Very High
narcan 9 91.40 High High
Disease Link Frequency Relevance Heat
INFLAMMATION 166 98.96 Very High Very High Very High
Nervous System Injury 28 98.28 Very High Very High Very High
Pain 133 98.12 Very High Very High Very High
Ganglion Cysts 31 97.44 Very High Very High Very High
Injury 8 89.68 High High
Inflammatory Pain 5 75.00 Quite High
Stress 3 74.84 Quite High
Hyperalgesia 3 74.28 Quite High
Nociception 77 72.64 Quite High
Neuropathic Pain 9 50.36 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
(iii) Opioid-containing leukocytes mostly expressed CXCR2.
Gene_expression (expressed) of CXCR2 in leukocytes associated with opioid
1) Confidence 0.69 Published 2004 Journal Pain Section Abstract Doc Link 15561377 Disease Relevance 0.27 Pain Relevance 1.76
Using flow cytometry, immunohistochemistry, and ELISA, leukocyte subpopulations, chemokine receptor (CXCR2) expression on opioid-containing leukocytes and the CXCR2 ligands keratinocyte-derived chemokine (KC), macrophage inflammatory protein-2 (MIP-2) and cytokine-induced neutrophil chemoattractant-2 (CINC-2) were quantified.
Gene_expression (expression) of CXCR2 in macrophage associated with chemokine, inflammation, opioid and cytokine
2) Confidence 0.69 Published 2004 Journal Pain Section Abstract Doc Link 15561377 Disease Relevance 0.48 Pain Relevance 1.40
Both GRO/KC and its primary receptor, CXCR2 (IL-8Rb) are expressed in neurons and other cells in the central nervous system, under both normal and pathological conditions [7-13].
Gene_expression (expressed) of IL-8Rb in neurons associated with central nervous system
3) Confidence 0.58 Published 2009 Journal Mol Pain Section Body Doc Link PMC2698898 Disease Relevance 1.53 Pain Relevance 1.32
Both GRO/KC and its primary receptor, CXCR2 (IL-8Rb) are expressed in neurons and other cells in the central nervous system, under normal and pathological conditions [11-17].
Gene_expression (expressed) of IL-8Rb in neurons associated with central nervous system
4) Confidence 0.58 Published 2008 Journal Mol Pain Section Body Doc Link PMC2562993 Disease Relevance 0.92 Pain Relevance 0.90
In cells expressing cloned CXCR2 receptors, the binding constant for GRO/KC was 0.2 nM [37].
Gene_expression (expressing) of CXCR2
5) Confidence 0.54 Published 2008 Journal Mol Pain Section Body Doc Link PMC2562993 Disease Relevance 0.21 Pain Relevance 0.29
In DRG sections, CXCR2 was expressed in most neurons, whether small, medium, or large diameter (Figure 8C, D).
Gene_expression (expressed) of CXCR2 in neurons
6) Confidence 0.54 Published 2008 Journal Mol Pain Section Body Doc Link PMC2562993 Disease Relevance 0 Pain Relevance 0.16
CXCR2 is expressed in both IB4-positive and IB4-negative neurons
Gene_expression (expressed) of CXCR2 in IB4
7) Confidence 0.54 Published 2008 Journal Mol Pain Section Body Doc Link PMC2562993 Disease Relevance 0 Pain Relevance 0.32
Using flow cytometry, immunohistochemistry, and ELISA, leukocyte subpopulations, chemokine receptor (CXCR2) expression on opioid-containing leukocytes and the CXCR2 ligands keratinocyte-derived chemokine (KC), macrophage inflammatory protein-2 (MIP-2) and cytokine-induced neutrophil chemoattractant-2 (CINC-2) were quantified.
Gene_expression (expression) of CXCR2 in macrophage associated with chemokine, inflammation, opioid and cytokine
8) Confidence 0.54 Published 2004 Journal Pain Section Abstract Doc Link 15561377 Disease Relevance 0.48 Pain Relevance 1.46
However, the number of high CXCR2 expressing cells was very small, approximately 2.4% of all DRG cells, making it likely that the other data reported in this study have a very small contribution from this subset of neurons with extremely high expression levels.
Gene_expression (expressing) of CXCR2 in neurons
9) Confidence 0.47 Published 2008 Journal Mol Pain Section Body Doc Link PMC2562993 Disease Relevance 0 Pain Relevance 0.21
Immunohistochemical staining of GRO/KC receptor CXCR2 in sectioned DRG tissue
Gene_expression (staining) of CXCR2
10) Confidence 0.47 Published 2008 Journal Mol Pain Section Body Doc Link PMC2562993 Disease Relevance 0 Pain Relevance 0.06
Immunohistochemical labelling confirmed that the CXCR2 receptor was present in most neurons both in dissociated cells and in DRG sections, as previously shown for neurons in the CNS.


Gene_expression (present) of CXCR2 receptor in neurons
11) Confidence 0.42 Published 2008 Journal Mol Pain Section Abstract Doc Link PMC2562993 Disease Relevance 0.17 Pain Relevance 0.37
Neurons and glia express its receptor (CXCR2).
Gene_expression (express) of CXCR2 in Neurons
12) Confidence 0.42 Published 2008 Journal Mol Pain Section Abstract Doc Link PMC2562993 Disease Relevance 0.57 Pain Relevance 0.39

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