INT12339

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Context Info
Confidence 0.81
First Reported 1992
Last Reported 2011
Negated 2
Speculated 2
Reported most in Abstract
Documents 437
Total Number 471
Disease Relevance 251.87
Pain Relevance 117.39

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (IL8) extracellular space (IL8) extracellular region (IL8)
intracellular (IL8)
Anatomy Link Frequency
neutrophils 40
epithelial cells 23
fibroblasts 22
monocytes 20
Caco-2 13
IL8 (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 6627 100.00 Very High Very High Very High
cytokine 4507 100.00 Very High Very High Very High
metalloproteinase 1916 100.00 Very High Very High Very High
chemokine 1782 100.00 Very High Very High Very High
Inflammatory mediators 489 100.00 Very High Very High Very High
Arthritis 411 100.00 Very High Very High Very High
substance P 141 100.00 Very High Very High Very High
Neurotransmitter 20 100.00 Very High Very High Very High
Somatostatin 5 100.00 Very High Very High Very High
Morphine 3916 99.92 Very High Very High Very High
Disease Link Frequency Relevance Heat
INFLAMMATION 8180 100.00 Very High Very High Very High
Cancer 3712 100.00 Very High Very High Very High
Arthritis 393 100.00 Very High Very High Very High
Necrosis 310 100.00 Very High Very High Very High
Osteoporosis 239 100.00 Very High Very High Very High
Occupational Lung Diseases 46 99.98 Very High Very High Very High
Death 1105 99.92 Very High Very High Very High
Alagille Syndrome 240 99.92 Very High Very High Very High
Pulmonary Disease 3489 99.90 Very High Very High Very High
Infection 2253 99.90 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
This suggests that propofol and midazolam alter interleukin-8 secretion from cells.
Localization (secretion) of interleukin-8 associated with versed
1) Confidence 0.81 Published 1998 Journal Anesth. Analg. Section Abstract Doc Link 9620522 Disease Relevance 0.09 Pain Relevance 0.33
These data strongly suggest that the anesthetics modulate transport or secretion of IL-8 protein from the cell.
Localization (secretion) of IL-8 protein
2) Confidence 0.81 Published 1998 Journal Anesth. Analg. Section Abstract Doc Link 9620522 Disease Relevance 0.14 Pain Relevance 0.37
Because this is not the case, these data indicate that O3 is not the sole inducer of IL-8 protein secretion, but that other photochemical products generated during the reactions of ISO or BD with sunlight are causing the increase in IL-8 production.
Localization (secretion) of IL-8
3) Confidence 0.81 Published 2004 Journal Environ Health Perspect Section Body Doc Link PMC1247611 Disease Relevance 0 Pain Relevance 0
No significant changes in IL-8 release were seen (Figure 5D) in cells exposed to the photochemical mixtures compared with the air-exposed control cells.
Localization (release) of IL-8
4) Confidence 0.81 Published 2004 Journal Environ Health Perspect Section Body Doc Link PMC1247611 Disease Relevance 0 Pain Relevance 0
Similar to IL-8 protein levels released into the basolateral supernatants, IL-8 mRNA levels were enhanced by both ISO and BD photochemical products, although the levels did not reach statistical significance.


Localization (released) of IL-8
5) Confidence 0.81 Published 2004 Journal Environ Health Perspect Section Body Doc Link PMC1247611 Disease Relevance 0 Pain Relevance 0
IL-8 (-251) A allele, which resulted in higher IL-8 secretion was associated with an increased risk and poor prognosis of colorectal cancer, prostate cancer, and gastric cancer [24-26,44].
Localization (secretion) of IL-8 associated with colon cancer, stomach cancer and reprotox - general 1
6) Confidence 0.80 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2895614 Disease Relevance 1.21 Pain Relevance 0
It has been reported that interleukin-8 (IL-8) is secreted from the placental and decidual tissues and that IL-8 levels in the amniotic fluids are significantly elevated by chorioamnionitis or labor pain.
Localization (secreted) of interleukin-8 in amniotic fluids associated with chorioamnionitis and pain labor
7) Confidence 0.80 Published 1994 Journal J. Reprod. Immunol. Section Abstract Doc Link 7738906 Disease Relevance 0.19 Pain Relevance 0.09
It has been reported that interleukin-8 (IL-8) is secreted from the placental and decidual tissues and that IL-8 levels in the amniotic fluids are significantly elevated by chorioamnionitis or labor pain.
Localization (secreted) of IL-8 in amniotic fluids associated with chorioamnionitis and pain labor
8) Confidence 0.80 Published 1994 Journal J. Reprod. Immunol. Section Abstract Doc Link 7738906 Disease Relevance 0.19 Pain Relevance 0.09
The present study was aimed at defining the localization of IL-8 mRNA as well as IL-8 protein at the feto-maternal interface using in situ hybridization and immunohistochemical staining.
Localization (localization) of IL-8
9) Confidence 0.80 Published 1994 Journal J. Reprod. Immunol. Section Abstract Doc Link 7738906 Disease Relevance 0.26 Pain Relevance 0.10
The present study was aimed at defining the localization of IL-8 mRNA as well as IL-8 protein at the feto-maternal interface using in situ hybridization and immunohistochemical staining.
Localization (localization) of IL-8
10) Confidence 0.80 Published 1994 Journal J. Reprod. Immunol. Section Abstract Doc Link 7738906 Disease Relevance 0.26 Pain Relevance 0.10
IL-8 secretion from glandular cells has not previously been reported.
Localization (secretion) of IL-8
11) Confidence 0.80 Published 1994 Journal J. Reprod. Immunol. Section Abstract Doc Link 7738906 Disease Relevance 0.26 Pain Relevance 0.08
In addition, we confirmed IL-8 mRNA expression and secretion of IL-8 by an endometrial cancer cell line (Ishikawa) using the reverse transcriptase-polymerase chain reaction (RT-PCR) and enzyme-linked immunosorbent assay (ELISA) methods, respectively.
Localization (secretion) of IL-8 associated with endometriosis (extended)
12) Confidence 0.80 Published 1994 Journal J. Reprod. Immunol. Section Abstract Doc Link 7738906 Disease Relevance 0.26 Pain Relevance 0.08
Both IL-8 mRNA and protein were localized in cytotrophoblast, syncytiotrophoblast and Hofbauer cells of the placenta, decidual stromal cells, decidual lymphocytes and endometrial gland cells.
Localization (localized) of IL-8 in syncytiotrophoblast
13) Confidence 0.80 Published 1994 Journal J. Reprod. Immunol. Section Abstract Doc Link 7738906 Disease Relevance 0.26 Pain Relevance 0.09
COMMON COLD: A rhinovirus, the causal agent usually found in common cold, stimulates the local abundance of polymorphonuclears resulting from IL8 secretion.
Localization (secretion) of IL8 associated with common cold
14) Confidence 0.80 Published 2001 Journal Presse Med Section Abstract Doc Link 11819910 Disease Relevance 0.59 Pain Relevance 0.19
The global amount of TNF-alpha released did not vary for IPN surfaces of different moduli; however, the amount of the pro-inflammatory cytokine IL-8 released demonstrated a biphasic response, where lower (approx. 1.4 kPa) and very high (approx. 348 kPa) moduli IPN surfaces attenuated IL-8 secretion.
Localization (secretion) of IL-8 associated with inflammation, ipn and cytokine
15) Confidence 0.79 Published 2008 Journal J Biomater Sci Polym Ed Section Abstract Doc Link 18854128 Disease Relevance 0.35 Pain Relevance 0.59
The secretion of human TNF-alpha, IL-10, IL-8 and IL-1beta from THP-1 cells attached to the IPNs was measured to assess the concentration of both pro- and anti-inflammatory cytokines.
Localization (secretion) of IL-8 in THP-1 associated with inflammation and cytokine
16) Confidence 0.79 Published 2008 Journal J Biomater Sci Polym Ed Section Abstract Doc Link 18854128 Disease Relevance 0.37 Pain Relevance 0.53
The different trends for TNF-alpha and IL-8 secretion highlight the complexity of the wound healing response, suggesting that there may not be a unique surface chemistry and substratum modulus combination that minimizes the pro-inflammatory cytokines produced by activated macrophages.
Localization (secretion) of IL-8 in macrophages associated with inflammation, wound healing and cytokine
17) Confidence 0.79 Published 2008 Journal J Biomater Sci Polym Ed Section Abstract Doc Link 18854128 Disease Relevance 0.44 Pain Relevance 0.59
Neutrophils stimulated with opsonized zymosan (0.3 mg/ml) released a large amount of IL-8 (p < 0.001), compared to controls.
Localization (released) of IL-8 in Neutrophils
18) Confidence 0.71 Published 2005 Journal Respir Res Section Body Doc Link PMC549028 Disease Relevance 0 Pain Relevance 0.04
release by monocytes and IL-8 release by neutrophils in vitro.
Localization (release) of IL-8 in monocytes
19) Confidence 0.71 Published 2005 Journal Respir Res Section Body Doc Link PMC549028 Disease Relevance 0.57 Pain Relevance 0.43
Inhibitory effects at 0.5 mg/ml of native, polymeric AAT and Prolastin on zymosan-mediated IL-8 release
Localization (release) of IL-8
20) Confidence 0.71 Published 2005 Journal Respir Res Section Body Doc Link PMC549028 Disease Relevance 0 Pain Relevance 0.03

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