INT123407

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Context Info
Confidence 0.47
First Reported 2004
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 6
Total Number 6
Disease Relevance 0.72
Pain Relevance 0.93

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (Sp1) intracellular (Sp1) DNA binding (Sp1)
transcription factor binding (Sp1) cytoplasm (Sp1)
Sp1 (Mus musculus)
Pain Link Frequency Relevance Heat
opioid receptor 13 99.84 Very High Very High Very High
Morphine 5 97.52 Very High Very High Very High
mu opioid receptor 80 94.08 High High
cytokine 39 80.60 Quite High
Analgesic 2 55.52 Quite High
Inflammatory response 9 35.36 Quite Low
Inflammation 12 5.00 Very Low Very Low Very Low
Pain 3 5.00 Very Low Very Low Very Low
IPN 3 5.00 Very Low Very Low Very Low
Central nervous system 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Sprains And Strains 42 97.84 Very High Very High Very High
Obesity 6 91.76 High High
Repression 14 65.00 Quite High
Disease 13 65.00 Quite High
Disorder Of Lipid Metabolism 6 63.04 Quite High
Atherosclerosis 33 62.32 Quite High
INFLAMMATION 21 35.36 Quite Low
Cytomegalovirus Infection 6 5.00 Very Low Very Low Very Low
Necrosis 3 5.00 Very Low Very Low Very Low
Aging 3 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
At this condition, mithramycin A could interfere the binding of positive transcriptional regulators such as Sp1 within the promoter region.


Negative_regulation (interfere) of Sp1 Binding (binding) of
1) Confidence 0.47 Published 2006 Journal Nucleic Acids Research Section Body Doc Link PMC1702488 Disease Relevance 0.07 Pain Relevance 0.17
Together, the A-to-C change at MOR 5'-UTR decreases Sp1 binding and MOR gene transcription, which could underlie the reduced morphine expression in CXBK mice.
Negative_regulation (decreases) of Sp1 Binding (binding) of associated with opioid receptor and morphine
2) Confidence 0.38 Published 2004 Journal Mol. Pharmacol. Section Abstract Doc Link 15562256 Disease Relevance 0 Pain Relevance 0.62
is mediated through decreased binding of Sp1 and Sp3 [29].
Negative_regulation (decreased) of Sp1 Binding (binding) of
3) Confidence 0.31 Published 2008 Journal Cell Signal Section Body Doc Link PMC2586094 Disease Relevance 0 Pain Relevance 0.04
The precise mechanisms underlying such regulation remain to be determined but could include direct phosphorylation-mediated reduction of Sp1 binding.
Negative_regulation (reduction) of Sp1 Binding (binding) of
4) Confidence 0.23 Published 2008 Journal Cell Signal Section Body Doc Link PMC2586094 Disease Relevance 0.34 Pain Relevance 0.04
-mediated downregulation of murine growth hormone receptor expression has been shown to be due to inhibition of Sp1 and Sp3 binding [30].
Negative_regulation (inhibition) of Sp1 Binding (binding) of
5) Confidence 0.23 Published 2008 Journal Cell Signal Section Body Doc Link PMC2586094 Disease Relevance 0 Pain Relevance 0.06
One of these SNPs, shown in TableĀ 3, disrupts a putative binding site for the transcription factor Sp-1 in the ISS sequence.
Negative_regulation (disrupts) of Sp-1 Binding (binding) of
6) Confidence 0.08 Published 2006 Journal Mamm Genome Section Body Doc Link PMC2677977 Disease Relevance 0.31 Pain Relevance 0

General Comments

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