INT123408

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Context Info
Confidence 0.62
First Reported 2004
Last Reported 2006
Negated 0
Speculated 0
Reported most in Abstract
Documents 2
Total Number 3
Disease Relevance 0.90
Pain Relevance 0.96

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (Sp1) intracellular (Sp1) DNA binding (Sp1)
transcription factor binding (Sp1) cytoplasm (Sp1)
Sp1 (Mus musculus)
Pain Link Frequency Relevance Heat
opioid receptor 10 99.04 Very High Very High Very High
cINOD 4 89.12 High High
Morphine 2 83.68 Quite High
Analgesic 1 61.20 Quite High
Disease Link Frequency Relevance Heat
Cancer 6 100.00 Very High Very High Very High
INFLAMMATION 2 87.68 High High
Pancreatic Cancer 4 75.00 Quite High
Metastasis 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In SL2 cells that lack endogenous Sp1 expression, B6 and CXBK MOR promoters demonstrated equal activity, whereas overexpression of Sp1 in SL2 cells enhanced B6 MOR promoter activity better than the CXBK promoter.
Positive_regulation (overexpression) of Gene_expression (overexpression) of Sp1 associated with opioid receptor
1) Confidence 0.62 Published 2004 Journal Mol. Pharmacol. Section Abstract Doc Link 15562256 Disease Relevance 0 Pain Relevance 0.62
For some cancers, Sp1 overexpression is associated with poor survival.
Positive_regulation (overexpression) of Gene_expression (overexpression) of Sp1
2) Confidence 0.49 Published 2006 Journal J. Natl. Cancer Inst. Section Abstract Doc Link 16788159 Disease Relevance 0.45 Pain Relevance 0.18
BACKGROUND: Sp1, Sp3, and Sp4 are transcription factors that regulate cell proliferation and vascular endothelial growth factor (VEGF) expression and are overexpressed in many cancer cell lines.
Positive_regulation (overexpressed) of Gene_expression (overexpressed) of Sp1 associated with cancer
3) Confidence 0.35 Published 2006 Journal J. Natl. Cancer Inst. Section Abstract Doc Link 16788159 Disease Relevance 0.44 Pain Relevance 0.16

General Comments

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