INT123409

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Context Info
Confidence 0.39
First Reported 2004
Last Reported 2008
Negated 1
Speculated 0
Reported most in Body
Documents 20
Total Number 20
Disease Relevance 3.18
Pain Relevance 3.15

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (Sp1) intracellular (Sp1) DNA binding (Sp1)
transcription factor binding (Sp1) cytoplasm (Sp1)
Anatomy Link Frequency
proximal 2
brain 1
NS20Y 1
Sp1 (Mus musculus)
Pain Link Frequency Relevance Heat
opioid receptor 40 99.80 Very High Very High Very High
cytokine 112 99.70 Very High Very High Very High
mu opioid receptor 507 99.64 Very High Very High Very High
Morphine 24 97.52 Very High Very High Very High
Glutamate receptor 7 97.52 Very High Very High Very High
Analgesic 9 80.36 Quite High
agonist 3 74.72 Quite High
Inflammation 54 64.36 Quite High
IPN 6 48.32 Quite Low
Pain 6 45.36 Quite Low
Disease Link Frequency Relevance Heat
Sprains And Strains 44 97.04 Very High Very High Very High
Obesity 30 91.24 High High
Atherosclerosis 66 88.96 High High
Repression 151 86.12 High High
Cancer 10 85.84 High High
Necrosis 10 85.36 High High
Hyperlipidemia 7 84.12 Quite High
Disorder Of Lipid Metabolism 30 81.04 Quite High
Diabetes Mellitus 7 78.36 Quite High
Disease 57 71.60 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
For MOR gene regulation, Sp1 factor acts as a major positive regulator by binding two cis-elements (distal and proximal promoters) located at ?
Sp1 Binding (binding) of in proximal associated with mu opioid receptor
1) Confidence 0.39 Published 2006 Journal Nucleic Acids Research Section Body Doc Link PMC1702488 Disease Relevance 0 Pain Relevance 0.35
At this condition, mithramycin A could interfere the binding of positive transcriptional regulators such as Sp1 within the promoter region.


Sp1 Binding (binding) of
2) Confidence 0.39 Published 2006 Journal Nucleic Acids Research Section Body Doc Link PMC1702488 Disease Relevance 0.06 Pain Relevance 0.16
Together, the A-to-C change at MOR 5'-UTR decreases Sp1 binding and MOR gene transcription, which could underlie the reduced morphine expression in CXBK mice.
Sp1 Binding (binding) of associated with opioid receptor and morphine
3) Confidence 0.33 Published 2004 Journal Mol. Pharmacol. Section Abstract Doc Link 15562256 Disease Relevance 0 Pain Relevance 0.62
In electrophoretic mobility shift assay, nuclear protein binding to the B6-Sp1 sequence was more efficient than to the CXBK-Sp1 sequence, and anti-Sp1 but not anti-CREB antibody interfered with the formation of the DNA-protein complex.
Sp1 Binding (binding) of
4) Confidence 0.32 Published 2004 Journal Mol. Pharmacol. Section Abstract Doc Link 15562256 Disease Relevance 0 Pain Relevance 0.50
In those upstream elements, Sp1 acts as a major activator by binding to both elements whereas Sp3 has minor activator effect.
Sp1 Binding (binding) of
5) Confidence 0.30 Published 2006 Journal Nucleic Acids Research Section Body Doc Link PMC1702488 Disease Relevance 0.06 Pain Relevance 0.22
After cross-linking the proteins and DNAs with formaldehyde, cell lysates from NS20Y cells were subjected to immunoprecipitation with NRSF, HDAC1, HDAC2, Sp1, Sp3 and IRF-4 (as a negative control).
Sp1 Binding (immunoprecipitation) of in NS20Y
6) Confidence 0.30 Published 2006 Journal Nucleic Acids Research Section Body Doc Link PMC1702488 Disease Relevance 0 Pain Relevance 0.25
In the co-immunoprecipitation experiment, NRSF interacted with the full-length Sp3 factor, but not with Sp1 or two short Sp3 isoforms.
Sp1 Neg (not) Binding (interacted) of
7) Confidence 0.29 Published 2006 Journal Nucleic Acids Research Section Abstract Doc Link PMC1702488 Disease Relevance 0.07 Pain Relevance 0.35
Although Sp1 and Sp3 share >90% sequence homology in the DNA-binding domain and they bind to the same cognate DNA element, they have strikingly different functions (30).
Sp1 Binding (bind) of
8) Confidence 0.29 Published 2006 Journal Nucleic Acids Research Section Body Doc Link PMC1702488 Disease Relevance 0 Pain Relevance 0.14
The precise mechanisms underlying such regulation remain to be determined but could include direct phosphorylation-mediated reduction of Sp1 binding.
Sp1 Binding (binding) of
9) Confidence 0.26 Published 2008 Journal Cell Signal Section Body Doc Link PMC2586094 Disease Relevance 0.34 Pain Relevance 0.04
is mediated through decreased binding of Sp1 and Sp3 [29].
Sp1 Binding (binding) of
10) Confidence 0.26 Published 2008 Journal Cell Signal Section Body Doc Link PMC2586094 Disease Relevance 0 Pain Relevance 0.04
Interestingly, a 10 bp Sp cis-acting element in the proximal promoter can function either as a negative element when bound to the M1 and M2 isoforms of Sp3 or as a positive element by interacting with Sp1 and Sp3[36].
Sp1 Binding (interacting) of in proximal
11) Confidence 0.21 Published 2006 Journal BMC Mol Biol Section Body Doc Link PMC1657025 Disease Relevance 0.17 Pain Relevance 0.10
Interestingly, a recent study investigating the mechanisms underlying the PI3K-mediated suppression of PMA-induced expression of p21WAF1/Cip1 showed that blocking of the PI3K/mTOR pathway was associated with increased binding by Sp1 [38].
Sp1 Binding (binding) of
12) Confidence 0.20 Published 2008 Journal Cell Signal Section Body Doc Link PMC2586094 Disease Relevance 0.07 Pain Relevance 0.03
-mediated downregulation of murine growth hormone receptor expression has been shown to be due to inhibition of Sp1 and Sp3 binding [30].
Sp1 Binding (binding) of
13) Confidence 0.20 Published 2008 Journal Cell Signal Section Body Doc Link PMC2586094 Disease Relevance 0 Pain Relevance 0.06
mediated via phosphorylation of Sp1 (and possibly Sp3), which leads to decreased binding to regulatory sequences in the LPL gene.
Sp1 Binding (binding) of
14) Confidence 0.19 Published 2008 Journal Cell Signal Section Body Doc Link PMC2586094 Disease Relevance 0.42 Pain Relevance 0.09
whereby the cytokine decreases the binding of Sp1 and Sp3 to three conserved recognition sequences in the regulatory region of the LPL gene [9].
Sp1 Binding (binding) of associated with cytokine
15) Confidence 0.19 Published 2008 Journal Cell Signal Section Body Doc Link PMC2586094 Disease Relevance 0.47 Pain Relevance 0.05
The strongest evidence for transcriptional dysregulation comes from the observed interaction between the glutamine rich regions of Sp1 with Huntingtin protein harbouring polyglutamine expansion in brain tissue from Huntington patients [11].
Sp1 Binding (interaction) of in brain
16) Confidence 0.13 Published 2007 Journal PLoS ONE Section Body Doc Link PMC2064964 Disease Relevance 0.25 Pain Relevance 0
One of these SNPs, shown in TableĀ 3, disrupts a putative binding site for the transcription factor Sp-1 in the ISS sequence.
Sp-1 Binding (binding) of
17) Confidence 0.07 Published 2006 Journal Mamm Genome Section Body Doc Link PMC2677977 Disease Relevance 0.31 Pain Relevance 0
In these cells, the inhibition of p38 MAPK affects the activity of the IL-10 promoter by inhibiting binding of the transcription factor Sp1 [81].
Sp1 Binding (binding) of
18) Confidence 0.06 Published 2006 Journal Arthritis Res Ther Section Body Doc Link PMC1526596 Disease Relevance 0.05 Pain Relevance 0.09
It was shown that the polymorphism influenced binding of Sp-1 resulting in higher transcriptional activity for the rare C allele than the common T allele.
Sp-1 Binding (binding) of
19) Confidence 0.03 Published 2006 Journal International Journal of Medical Sciences Section Body Doc Link PMC1525216 Disease Relevance 0.60 Pain Relevance 0.04
Alternative splicing events are generally regulated by complex interactions between multiple cis-acting pre-mRNA elements and trans-acting protein factors.
trans-acting Binding (interactions) of
20) Confidence 0.01 Published 2007 Journal PLoS Biology Section Body Doc Link PMC1790950 Disease Relevance 0.30 Pain Relevance 0

General Comments

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