INT123410

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Context Info
Confidence 0.38
First Reported 2004
Last Reported 2008
Negated 0
Speculated 0
Reported most in Abstract
Documents 3
Total Number 3
Disease Relevance 1.01
Pain Relevance 0.82

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (Sp1) intracellular (Sp1) DNA binding (Sp1)
transcription factor binding (Sp1) cytoplasm (Sp1)
Sp1 (Mus musculus)
Pain Link Frequency Relevance Heat
opioid receptor 10 99.44 Very High Very High Very High
cINOD 2 97.92 Very High Very High Very High
Morphine 2 76.80 Quite High
Analgesic 1 65.00 Quite High
Kinase C 2 5.00 Very Low Very Low Very Low
tolerance 1 5.00 Very Low Very Low Very Low
abdominal pain 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cancer 3 100.00 Very High Very High Very High
INFLAMMATION 1 97.20 Very High Very High Very High
Pancreatic Cancer 2 92.56 High High
Metastasis 1 91.44 High High
Hypopituitarism 11 72.64 Quite High
Cataract 4 61.08 Quite High
Targeted Disruption 8 56.96 Quite High
Reprotox - General 3 1 55.08 Quite High
Frailty 3 54.16 Quite High
Myotonic Dystrophy 8 50.00 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In SL2 cells that lack endogenous Sp1 expression, B6 and CXBK MOR promoters demonstrated equal activity, whereas overexpression of Sp1 in SL2 cells enhanced B6 MOR promoter activity better than the CXBK promoter.
Negative_regulation (lack) of Gene_expression (expression) of Sp1 associated with opioid receptor
1) Confidence 0.38 Published 2004 Journal Mol. Pharmacol. Section Abstract Doc Link 15562256 Disease Relevance 0 Pain Relevance 0.63
Cyclooxygenase inhibitors decrease Sp1 expression in cancer cells, and therefore different structural classes of nonsteroidal anti-inflammatory drugs (NSAIDs) were screened for their ability to decrease levels of Sp1, Sp3, and Sp4 and to decrease pancreatic tumor growth and metastasis in an in vivo model.
Negative_regulation (decrease) of Gene_expression (expression) of Sp1 associated with inflammation, cancer, pancreatic cancer, cinod and metastasis
2) Confidence 0.30 Published 2006 Journal J. Natl. Cancer Inst. Section Abstract Doc Link 16788159 Disease Relevance 0.65 Pain Relevance 0.19
Measured fractions of Specificity protein 1 (Sp1), Signal Transducer and Activator of Transcription (STAT1 and STAT3) and Retinoic Acid Receptor gamma (RAR?)
Negative_regulation (Measured) of Gene_expression (fractions) of Sp1
3) Confidence 0.10 Published 2008 Journal Current Genomics Section Body Doc Link PMC2694559 Disease Relevance 0.36 Pain Relevance 0

General Comments

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