INT123411

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Context Info
Confidence 0.69
First Reported 2004
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 15
Total Number 15
Disease Relevance 4.20
Pain Relevance 3.79

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (Sp1) intracellular (Sp1) DNA binding (Sp1)
transcription factor binding (Sp1) cytoplasm (Sp1)
Anatomy Link Frequency
liver 1
proximal region 1
Sp1 (Mus musculus)
Pain Link Frequency Relevance Heat
opioid receptor 41 100.00 Very High Very High Very High
cINOD 10 98.84 Very High Very High Very High
mu opioid receptor 244 98.66 Very High Very High Very High
Analgesic 5 96.84 Very High Very High Very High
Inflammation 133 95.76 Very High Very High Very High
Morphine 14 94.04 High High
Inflammatory response 22 85.20 High High
agonist 1 62.68 Quite High
opiate 1 62.32 Quite High
analgesia 1 51.84 Quite High
Disease Link Frequency Relevance Heat
Cancer 38 100.00 Very High Very High Very High
Pancreatic Cancer 10 99.24 Very High Very High Very High
INFLAMMATION 100 98.56 Very High Very High Very High
Metastasis 5 98.12 Very High Very High Very High
Cirrhosis 6 90.32 High High
Cardiovascular Disease 1 87.88 High High
Hyperglycemia 2 82.32 Quite High
Repression 36 74.44 Quite High
Hypopituitarism 11 72.64 Quite High
Diabetes Mellitus 3 71.80 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In SL2 cells that lack endogenous Sp1 expression, B6 and CXBK MOR promoters demonstrated equal activity, whereas overexpression of Sp1 in SL2 cells enhanced B6 MOR promoter activity better than the CXBK promoter.
Gene_expression (overexpression) of Sp1 associated with opioid receptor
1) Confidence 0.69 Published 2004 Journal Mol. Pharmacol. Section Abstract Doc Link 15562256 Disease Relevance 0 Pain Relevance 0.62
In SL2 cells that lack endogenous Sp1 expression, B6 and CXBK MOR promoters demonstrated equal activity, whereas overexpression of Sp1 in SL2 cells enhanced B6 MOR promoter activity better than the CXBK promoter.
Gene_expression (expression) of Sp1 associated with opioid receptor
2) Confidence 0.69 Published 2004 Journal Mol. Pharmacol. Section Abstract Doc Link 15562256 Disease Relevance 0 Pain Relevance 0.62
Within the Sp family transcription factors, Sp1 and Sp3 are ubiquitously expressed in mammalian cells.
Gene_expression (expressed) of Sp1
3) Confidence 0.62 Published 2006 Journal Nucleic Acids Research Section Body Doc Link PMC1702488 Disease Relevance 0 Pain Relevance 0.13
Differential expression of mu-opioid receptor gene in CXBK and B6 mice by Sp1.
Gene_expression (expression) of Sp1 associated with opioid receptor
4) Confidence 0.60 Published 2004 Journal Mol. Pharmacol. Section Title Doc Link 15562256 Disease Relevance 0 Pain Relevance 0.56
Cyclooxygenase inhibitors decrease Sp1 expression in cancer cells, and therefore different structural classes of nonsteroidal anti-inflammatory drugs (NSAIDs) were screened for their ability to decrease levels of Sp1, Sp3, and Sp4 and to decrease pancreatic tumor growth and metastasis in an in vivo model.
Gene_expression (expression) of Sp1 associated with inflammation, cancer, pancreatic cancer, cinod and metastasis
5) Confidence 0.55 Published 2006 Journal J. Natl. Cancer Inst. Section Abstract Doc Link 16788159 Disease Relevance 0.65 Pain Relevance 0.19
For some cancers, Sp1 overexpression is associated with poor survival.
Gene_expression (overexpression) of Sp1
6) Confidence 0.55 Published 2006 Journal J. Natl. Cancer Inst. Section Abstract Doc Link 16788159 Disease Relevance 0.45 Pain Relevance 0.18
189 of MOR gene (4), (iii) Sp3 acts as a weak positive element by binding to Sp1 sites at the proximal region (?
Gene_expression (sites) of Sp1 in proximal region associated with mu opioid receptor
7) Confidence 0.54 Published 2006 Journal Nucleic Acids Research Section Body Doc Link PMC1702488 Disease Relevance 0.14 Pain Relevance 0.20
BACKGROUND: Sp1, Sp3, and Sp4 are transcription factors that regulate cell proliferation and vascular endothelial growth factor (VEGF) expression and are overexpressed in many cancer cell lines.
Gene_expression (overexpressed) of Sp1 associated with cancer
8) Confidence 0.48 Published 2006 Journal J. Natl. Cancer Inst. Section Abstract Doc Link 16788159 Disease Relevance 0.44 Pain Relevance 0.16
Cyclooxygenase inhibitors decrease Sp1 expression in cancer cells, and therefore different structural classes of nonsteroidal anti-inflammatory drugs (NSAIDs) were screened for their ability to decrease levels of Sp1, Sp3, and Sp4 and to decrease pancreatic tumor growth and metastasis in an in vivo model.
Gene_expression (levels) of Sp1 associated with inflammation, cancer, pancreatic cancer, cinod and metastasis
9) Confidence 0.43 Published 2006 Journal J. Natl. Cancer Inst. Section Abstract Doc Link 16788159 Disease Relevance 0.65 Pain Relevance 0.20
In the mouse model for pancreatic cancer, treatment with tolfenamic acid (50 mg/kg of body weight), compared with control treatment, statistically significantly decreased tumor growth and weight (P = .005), liver metastasis (P = .027), and levels of Sp3 and VEGF (P = .009) and Sp1 and Sp4 (P = .006) proteins in tumors.
Gene_expression (levels) of Sp1 in liver
10) Confidence 0.43 Published 2006 Journal J. Natl. Cancer Inst. Section Body Doc Link 16788159 Disease Relevance 0.11 Pain Relevance 0
Our laboratory and others have demonstrated that MOR promoter activity is regulated by many enhancer elements and their related transcriptional factors such as SOX, SP1, AP2, NF-?
Gene_expression (factors) of SP1 associated with mu opioid receptor
11) Confidence 0.37 Published 2007 Journal Nucleic Acids Research Section Body Doc Link PMC1865057 Disease Relevance 0.06 Pain Relevance 0.54
The assay was therefore repeated with recombinant human Sp1 (rhSp1) produced in Sf9 cells using a baculovirus expression system (Promega).
Gene_expression (produced) of Sp1
12) Confidence 0.32 Published 2008 Journal Cell Signal Section Body Doc Link PMC2586094 Disease Relevance 0 Pain Relevance 0
Measured fractions of Specificity protein 1 (Sp1), Signal Transducer and Activator of Transcription (STAT1 and STAT3) and Retinoic Acid Receptor gamma (RAR?)
Gene_expression (fractions) of Sp1
13) Confidence 0.16 Published 2008 Journal Current Genomics Section Body Doc Link PMC2694559 Disease Relevance 0.36 Pain Relevance 0
, SP-1, STAT-3/-5, YY1).
Gene_expression (/) of SP-1
14) Confidence 0.11 Published 2007 Journal Genome Biol Section Body Doc Link PMC2375038 Disease Relevance 1.23 Pain Relevance 0.39
Putative binding sites for several known transcription factors, namely Sp1, E2F, CdxA, GATA, c-Ets, HSF2, Ik2, USF and SRY are found in the upstream region [28].
Gene_expression (found) of Sp1
15) Confidence 0.09 Published 2008 Journal Current Genomics Section Body Doc Link PMC2691673 Disease Relevance 0.12 Pain Relevance 0

General Comments

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