INT123412

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.56
First Reported 2004
Last Reported 2006
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 0.06
Pain Relevance 0.79

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Oprm1) plasma membrane (Oprm1) signal transducer activity (Oprm1)
Oprm1 (Mus musculus)
Pain Link Frequency Relevance Heat
mu opioid receptor 80 100.00 Very High Very High Very High
opioid receptor 13 100.00 Very High Very High Very High
Morphine 5 98.60 Very High Very High Very High
Analgesic 2 55.52 Quite High
Central nervous system 1 5.00 Very Low Very Low Very Low
Glutamate receptor 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Repression 14 58.44 Quite High
Disease 4 5.00 Very Low Very Low Very Low
Targeted Disruption 2 5.00 Very Low Very Low Very Low
Neurodegenerative Disease 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Together, the A-to-C change at MOR 5'-UTR decreases Sp1 binding and MOR gene transcription, which could underlie the reduced morphine expression in CXBK mice.
Negative_regulation (decreases) of Transcription (transcription) of MOR gene associated with opioid receptor and morphine
1) Confidence 0.56 Published 2004 Journal Mol. Pharmacol. Section Abstract Doc Link 15562256 Disease Relevance 0 Pain Relevance 0.62
Sp3 interacts with NRSF and binds G/C box adjacent to NRSE to repress transcription of MOR gene
Negative_regulation (repress) of Transcription (transcription) of MOR associated with mu opioid receptor
2) Confidence 0.36 Published 2006 Journal Nucleic Acids Research Section Body Doc Link PMC1702488 Disease Relevance 0.06 Pain Relevance 0.17

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox